how to do a medical research project

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How to Write a Medical Research Paper

Last Updated: February 5, 2024 Approved

This article was co-authored by Chris M. Matsko, MD . Dr. Chris M. Matsko is a retired physician based in Pittsburgh, Pennsylvania. With over 25 years of medical research experience, Dr. Matsko was awarded the Pittsburgh Cornell University Leadership Award for Excellence. He holds a BS in Nutritional Science from Cornell University and an MD from the Temple University School of Medicine in 2007. Dr. Matsko earned a Research Writing Certification from the American Medical Writers Association (AMWA) in 2016 and a Medical Writing & Editing Certification from the University of Chicago in 2017. wikiHow marks an article as reader-approved once it receives enough positive feedback. In this case, 89% of readers who voted found the article helpful, earning it our reader-approved status. This article has been viewed 202,510 times.

Writing a medical research paper is similar to writing other research papers in that you want to use reliable sources, write in a clear and organized style, and offer a strong argument for all conclusions you present. In some cases the research you discuss will be data you have actually collected to answer your research questions. Understanding proper formatting, citations, and style will help you write and informative and respected paper.

Researching Your Paper

• Pick something that really interests you to make the research more fun.
• Choose a topic that has unanswered questions and propose solutions.

• Quantitative studies consist of original research performed by the writer. These research papers will need to include sections like Hypothesis (or Research Question), Previous Findings, Method, Limitations, Results, Discussion, and Application.
• Synthesis papers review the research already published and analyze it. They find weaknesses and strengths in the research, apply it to a specific situation, and then indicate a direction for future research.

• Keep track of your sources. Write down all publication information necessary for citation: author, title of article, title of book or journal, publisher, edition, date published, volume number, issue number, page number, and anything else pertaining to your source. A program like Endnote can help you keep track of your sources.
• Take detailed notes as you read. Paraphrase information in your own words or if you copy directly from the article or book, indicate that these are direct quotes by using quotation marks to prevent plagiarism.
• Be sure to keep all of your notes with the correct source.
• Your professor and librarians can also help you find good resources.

• Keep all of your notes in a physical folder or in a digitized form on the computer.
• Start to form the basic outline of your paper using the notes you have collected.

Writing Your Paper

• Start with bullet points and then add in notes you've taken from references that support your ideas. [1] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
• A common way to format research papers is to follow the IMRAD format. This dictates the structure of your paper in the following order: I ntroduction, M ethods, R esults, a nd D iscussion. [2] X Research source
• The outline is just the basic structure of your paper. Don't worry if you have to rearrange a few times to get it right.
• Ask others to look over your outline and get feedback on the organization.
• Know the audience you are writing for and adjust your style accordingly. [3] X Research source

• Use a standard font type and size, such as Times New Roman 12 point font.
• Double-space your paper.
• If necessary, create a cover page. Most schools require a cover page of some sort. Include your main title, running title (often a shortened version of your main title), author's name, course name, and semester.

• Break up information into sections and subsections and address one main point per section.
• Include any figures or data tables that support your main ideas.
• For a quantitative study, state the methods used to obtain results.

• Clearly state and summarize the main points of your research paper.
• Discuss how this research contributes to the field and why it is important. [4] X Research source
• Highlight potential applications of the theory if appropriate.
• Propose future directions that build upon the research you have presented. [5] X Research source
• Keep the introduction and discussion short, and spend more time explaining the methods and results.

• State why the problem is important to address.
• Discuss what is currently known and what is lacking in the field.
• State the objective of your paper.
• Keep the introduction short.

• Highlight the purpose of the paper and the main conclusions.
• State why your conclusions are important.
• Be concise in your summary of the paper.
• Show that you have a solid study design and a high-quality data set.
• Abstracts are usually one paragraph and between 250 – 500 words.

• Unless otherwise directed, use the American Medical Association (AMA) style guide to properly format citations.
• Add citations at end of a sentence to indicate that you are using someone else's idea. Use these throughout your research paper as needed. They include the author's last name, year of publication, and page number.
• Compile your reference list and add it to the end of your paper.
• Use a citation program if you have access to one to simplify the process.

• Continually revise your paper to make sure it is structured in a logical way.
• Proofread your paper for spelling and grammatical errors.
• Make sure you are following the proper formatting guidelines provided for the paper.
• Have others read your paper to proofread and check for clarity. Revise as needed.

Expert Q&A

• Ask your professor for help if you are stuck or confused about any part of your research paper. They are familiar with the style and structure of papers and can provide you with more resources. Thanks Helpful 0 Not Helpful 0
• Refer to your professor's specific guidelines. Some instructors modify parts of a research paper to better fit their assignment. Others may request supplementary details, such as a synopsis for your research project . Thanks Helpful 0 Not Helpful 0
• Set aside blocks of time specifically for writing each day. Thanks Helpful 0 Not Helpful 0

• Do not plagiarize. Plagiarism is using someone else's work, words, or ideas and presenting them as your own. It is important to cite all sources in your research paper, both through internal citations and on your reference page. Thanks Helpful 4 Not Helpful 2

You Might Also Like

• ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178846/
• ↑ http://owl.excelsior.edu/research-and-citations/outlining/outlining-imrad/
• ↑ http://china.elsevier.com/ElsevierDNN/Portals/7/How%20to%20write%20a%20world-class%20paper.pdf
• ↑ http://intqhc.oxfordjournals.org/content/16/3/191
• ↑ http://www.ruf.rice.edu/~bioslabs/tools/report/reportform.html#form

About This Article

To write a medical research paper, research your topic thoroughly and compile your data. Next, organize your notes and create a strong outline that breaks up the information into sections and subsections, addressing one main point per section. Write the results and discussion sections first to go over your findings, then write the introduction to state your objective and provide background information. Finally, write the abstract, which concisely summarizes the article by highlighting the main points. For tips on formatting and using citations, read on! Did this summary help you? Yes No

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A Realistic Guide to Medical School

Written by UCL students for students

Top 10 Tips: Getting into Research as a Medical Student

Introducing our new series: Top 10 Tips – a simple guide to help you achieve your goals!

In this blog post, Jessica Xie (final year UCL medical student) shares advice on getting into research as a medical student.

Disclaimers: 

• Research is not a mandatory for career progression, nor is it required to demonstrate your interest in medicine. 
• You can dip into and out of research throughout your medical career. Do not feel that you must continue to take on new projects once you have started; saying “no, thank you” to project opportunities will allow you to focus your energy and time on things in life that you are more passionate about for a more rewarding experience.
• Do not take on more work than you are capable of managing. Studying medicine is already a full-time job! It’s physically and mentally draining. Any research that you get involved with is an extracurricular interest.

I decided to write this post because, as a pre-clinical medical student, I thought that research only involved wet lab work (i.e pipetting substances into test tubes). However, upon undertaking an intercalated Bachelor of Science (iBSc) in Primary Health Care, I discovered that there are so many different types of research! And academic medicine became a whole lot more exciting…

Here are my Top 10 Tips on what to do if you’re a little unsure about what research is and how to get into it:

TIP 1: DO YOUR RESEARCH (before getting into research)

There are three questions that I think you should ask yourself:

• What are my research interests?

Examples include a clinical specialty, medical education, public health, global health, technology… the list is endless. Not sure? That’s okay too! The great thing about research is that it allows deeper exploration of an area of Medicine (or an entirely different field) to allow you to see if it interests you.

2.  What type of research project do I want to do?

Research evaluates practice or compares alternative practices to contribute to, lend further support to or fill in a gap in the existing literature.

There are many different types of research – something that I didn’t fully grasp until my iBSc year. There is primary research, which involves data collection, and secondary research, which involves using existing data to conduct further research or draw comparisons between the data (e.g. a meta-analysis of randomised control trials). Studies are either observational (non-interventional) (e.g. case-control, cross-sectional) or interventional (e.g. randomised control trial).

An audit is a way of finding out if current practice is best practice and follows guidelines. It identifies areas of clinical practice could be improved.

Another important thing to consider is: how much time do I have? Developing the skills required to lead a project from writing the study protocol to submitting a manuscript for publication can take months or even years. Whereas, contributing to a pre-planned or existing project by collecting or analysing data is less time-consuming. I’ll explain how you can find such projects below.

3.  What do I want to gain from this experience?

Do you want to gain a specific skill? Mentorship? An overview of academic publishing? Or perhaps to build a research network?

After conducting a qualitative interview study for my iBSc project, I applied for an internship because I wanted to gain quantitative research skills. I ended up leading a cross-sectional questionnaire study that combined my two research interests: medical education and nutrition. I sought mentorship from an experienced statistician, who taught me how to use SPSS statistics to analyse and present the data.

Aside from specific research skills, don’t forget that you will develop valuable transferable skills along the way, including time-management, organisation, communication and academic writing! 

TIP 2: BE PROACTIVE

Clinicians and lecturers are often very happy for medical students to contribute to their research projects. After a particularly interesting lecture/ tutorial, ward round or clinic, ask the tutor or doctors if they have any projects that you could help them with! 

TIP 3: NETWORKING = MAKING YOUR OWN LUCK

Sometimes the key to getting to places is not what you know, but who you know. We can learn a lot from talking to peers and senior colleagues. Attending hospital grand rounds and conferences are a great way to meet people who share common interests with you but different experiences. I once attended a conference in Manchester where I didn’t know anybody. I befriended a GP, who then gave me tips on how to improve my poster presentation. He shared with me his experience of the National institute of Health Research (NIHR) Integrated Academic Training Pathway and motivated me to continue contributing to medical education alongside my studies.

TIP 4: UTILISE SOCIAL MEDIA

Research opportunities, talks and workshops are advertised on social media in abundance. Here are some examples:

Search “medical student research” or “medsoc research” into Facebook and lots of groups and pages will pop up, including UCL MedSoc Research and Academic Medicine (there is a  Research Mentoring Scheme Mentee Scheme), NSAMR – National Student Association of Medical Research and International Opportunities for Medical Students .

Search #MedTwitter and #AcademicTwitter to keep up to date with ground-breaking research. The memes are pretty good too.

Opportunities are harder to come by on LinkedIn, since fewer medical professionals use this platform. However, you can look at peoples’ resumes as a source of inspiration. This is useful to understand the experiences that they have had in order to get to where they are today. You could always reach out to people and companies/ organisations for more information and advice.

TIP 5: JOIN A PRE-PLANNED RESEARCH PROJECT

Researchers advertise research opportunities on websites and via societies and organisations such as https://www.remarxs.com and http://acamedics.org/Default.aspx . 

TIP 6: JOIN A RESEARCH COLLABORATIVE

Research collaboratives are multiprofessional groups that work towards a common research goal. These projects can result in publications and conference presentations. However, more importantly, this is a chance to establish excellent working relationships with like-minded individuals.

Watch out for opportunities posted on Student Training and Research Collaborative .

Interested in academic surgery? Consider joining StarSurg , BURST Urology , Project Cutting Edge or Academic Surgical Collaborative .

Got a thing for global health? Consider joining Polygeia . 

TIP 7: THE iBSc YEAR: A STEPPING STONE INTO RESEARCH

At UCL you will complete an iBSc in third year. This is often students’ first taste of being involved in research and practicing academic writing – it was for me. The first-ever project that I was involved in was coding data for a systematic review. One of the Clinical Teaching Fellows ended the tutorial by asking if any students would be interested in helping with a research project. I didn’t really know much about research at that point and was curious to learn, so I offered to help. Although no outputs were generated from that project, I gained an understanding of how to conduct a systematic review, why the work that I was contributing to was important, and I learnt a thing or two about neonatal conditions. 

TIP 8: VENTURE INTO ACADEMIC PUBLISHING

One of the best ways to get a flavour of research is to become involved in academic publishing. There are several ways in which you could do this:

Become a peer reviewer. This role involves reading manuscripts (papers) that have been submitted to journals and providing feedback and constructive criticism. Most journals will provide you with training or a guide to follow when you write your review. This will help you develop skills in critical appraisal and how to write an academic paper or poster. Here are a few journals which you can apply to:

• https://thebsdj.cardiffuniversitypress.org
• Journal of the National Student Association of Medical Researchjournal.nsamr.ac.uk
• https://cambridgemedicine.org/about  
• https://www.bmj.com/about-bmj/resources-reviewers  

Join a journal editorial board/ committee. This is a great opportunity to gain insight into how a medical journal is run and learn how to get published. The roles available depend on the journal, from Editor-in-Chief to finance and operations and marketing. I am currently undertaking a Social Media Fellowship at BJGP Open, and I came across the opportunity on Twitter! Here are a few examples of positions to apply for:

• Journal of the National Student Association of Medical Researchjournal.nsamr.ac.uk – various positions in journalism, education and website management
• https://nsamr.ac.uk – apply for a position on the executive committee or as a local ambassador
• Student BMJ Clegg Scholarship
• BJGP Open Fellowships

TIP 9: GAIN EXPERIENCE IN QUALITY IMPROVEMENT

UCL Be the Change is a student-led initiative that allows students to lead and contribute to bespoke QIPs. You will develop these skills further when you conduct QIPs as part of your year 6 GP placement and as a foundation year doctor.

TIP 10: CONSIDER BECOMING A STUDENT REPRESENTATIVE

You’ll gain insight into undergraduate medical education as your role will involve gathering students’ feedback on teaching, identifying areas of curriculum that could be improved and working with the faculty and other student representatives to come up with solutions. 

It may not seem like there are any research opportunities up for grabs, but that’s where lateral thinking comes into play: the discussions that you have with your peers and staff could be a source of inspiration for a potential medical education research project. For example, I identified that, although we have lectures in nutrition science and public health nutrition, there was limited clinically-relevant nutrition teaching on the curriculum. I then conducted a learning needs assessment and contributed to developing the novel Nutrition in General Practice Day course in year 5.

Thanks for reaching the end of this post! I hope my Top 10 Tips are useful. Remember, research experience isn’t essential to become a great doctor, but rather an opportunity to explore a topic of interest further.

One thought on “Top 10 Tips: Getting into Research as a Medical Student”

This article was extremely helpful! Alothough, I’m only a junior in high school I have a few questions. First, is there anyway to prepare myself mentally for this challenging road to becoming a doctor? check our PACIFIC best medical college in Rajasthan

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How to get involved in research as a medical student

• Related content
• Peer review
• Anna Kathryn Taylor , final year medical student 1 ,
• Sarah Purdy , professor of primary care and associate dean 1
• 1 Faculty of Health Sciences, University of Bristol, UK

Participating in research gives students great skills and opportunities. Anna Taylor and Sarah Purdy explain how to get started

This article contains:

-How to get involved with research projects

-Questions to ask yourself before starting research

-What can you get published? Research output

-Advice for contacting researchers

-Different types of research explained

-Stages of research projects

Students often go into medicine because of a desire to help others and improve patients’ physical and mental wellbeing. In the early years of medical school, however, it can seem as if you are not making much difference to patient care. Involvement in research can provide exciting opportunities to work as part of a team, improve career prospects, and most importantly add to the evidence base, leading to better outcomes for patients.

Research is usually multidisciplinary, including clinical academics (medical doctors who spend part of their working life doing research), nurses, patients, scientists, and researchers without a medical background. Involvement in such a team can improve your communication skills and expand your understanding of how a multidisciplinary team works.

Participating in research can also help you to develop skills in writing and critical appraisal through the process of publishing your work. You may be able to present your work at conferences—either as a poster or an oral presentation—and this can provide valuable points for job applications at both foundation programme and core training level. This is particularly important if you are considering a career in academia. You will also develop skills in time management, problem solving, and record keeping. You might discover an area of medicine in which you are keen to carry out further work. For some people, getting involved in research as a medical student can be the first step in an academic career.

Kyla Thomas, National Institute for Health Research clinical lecturer in public health at the University of Bristol, says, “my first baby steps into a clinical academic career started with a research project I completed as a medical student. That early involvement in research opened my eyes to a whole new world of opportunities that I never would have considered.

“Importantly, participating in undergraduate research sets students apart from their colleagues. Applying for foundation posts is a competitive process and it is a definite advantage if you have managed to obtain a peer reviewed publication.”

Getting involved with research projects

Although it is possible to do research at medical school, it is important to be realistic about how much free time you have. It might be possible to set up your own research project, but this will require substantial planning in terms of writing research protocols, gaining ethical approval, and learning about new research methodologies. Other opportunities for research that make less demands on your time include:

Intercalated degrees—these often have time set aside for research in a specific area, so it is important to choose your degree according to what you might like to do for your dissertation (for example, laboratory-based work in biochemistry, or qualitative research in global health. Some subjects may have options in both qualitative and quantitative research).

Student selected components or modules can provide a good opportunity to be involved in an ongoing study or research project. If you have a long project period, you might be able to develop your own small project.

Electives and summer holidays can also provide dedicated time for research, either within the United Kingdom or in another country. They can allow you to become established in a research group if you’re there for a few weeks, and can lead to a longstanding relationship with the research group if you continue to work with them over your medical school career.

If you don’t know what to do, contacting the Student Audit and Research in Surgery (STARSurg), 1 the National Student Association of Medical Research (NSAMR), 2 or your medical school’s research society may be a good place to start.

The INSPIRE initative, 3 coordinated by the Academy of Medical Sciences, gives support and grants to help students take part in research. Some UK medical schools have small grants for elective and summer projects, and organise taster days for students to get an idea of different research areas.

You may also be able to access other grants or awards to support your research. Some of the royal colleges, such as the Royal College of General Practitioners and the Royal College of Psychiatrists, offer bursaries to students doing research in their holidays or presenting at conferences. Other national organisations, such as the Medical Women’s Federation, offer bursaries for elective projects.

Box 1: Questions to ask yourself before starting research

What are you interested in? There is no point getting involved in a project area that you find boring.

How much time do you have available? It is crucial to think about this before committing to a project, so that your supervisor can give you an appropriate role.

What do you want to get out of your research experience? Do you want a brief insight into research? Or are you hoping for a publication or presentation?

Do you know any peers or senior medical students who are involved in research? Ask them about their experiences and whether they know of anyone who might be willing to include you in a project.

Box 2: Research output

Publication —This is the “gold standard” of output and usually consists of an article published in a PubMed ID journal. This can lead to your work being cited by another researcher for their paper, and you can get up to two extra points on foundation programme applications if you have published papers with a PubMed ID.

Not all research will get published, but there are other ways to show your work, such as presenting at conferences:

Oral presentation —This involves giving a short talk about your research, describing the background, methods, and results, then talking about the implications of your findings.

Poster presentation —This involves creating a poster, usually A1 or A2 in size, summarising the background, methods, and results of your research. At a conference, presenters stand by their poster and answer questions from other delegates.

Contacting researchers

Most universities have information about their research groups on their websites, so spend some time exploring what studies are being carried out and whether you are interested in one of the research topics.

When contacting a member of the research group, ask if they or someone else within their team would be willing to offer you some research experience. Be honest if you don’t have any prior experience and about the level of involvement you are looking for, but emphasise what it is about their research that interests you and why you want to work with them. It’s important to have a flexible approach to what they offer you—it may not initially sound very exciting, but it will be a necessary part of the research process, and may lead to more interesting research activity later.

Another way to make contact with researchers is at university talks or lectures. It might be intimidating to approach senior academics, but if you talk to them about your interest they will be more likely to remember you if you contact them later on.

Box 3: What can students offer research teams?—Views from researchers

“Medical students come to research with a ‘fresh eyes’ perspective and a questioning mindset regarding the realities of clinical practice which, as a non-medic myself, serves to remind me of the contextual challenges of implementing recommendations from our work.”

Alison Gregory, senior research associate, Centre for Academic Primary Care, University of Bristol, UK.

“Enthusiasm, intelligence, and a willingness to learn new skills to solve challenges—bring those attributes and you’ll be valuable to most research teams.”

Tony Pickering, consultant anaesthetist and Wellcome Trust senior research fellow, University of Bristol, UK.

Box 4: Different types of research

Research aims to achieve new insights into disease, investigations, and treatment, using methodologies such as the ones listed below:

Qualitative research —This can be used to develop a theory and to explain how and why people behave as they do. 4 It usually involves exploring the experience of illness, therapeutic interventions, or relationships, and can be compiled using focus groups, structured interviews, consultation analysis, 5 or ethnography. 6

Quantitative research —This aims to quantify a problem by generating numerical data, and may test a hypothesis. 7 Research projects can use chemicals, drugs, biological matter, or even computer generated models. Quantitative research might also involve using statistics to evaluate or compare interventions, such as in a randomised controlled trial.

Epidemiological research —This is the study of the occurrence and distribution of disease, the determinants influencing health and disease states, and the opportunities for prevention. It often involves the analysis of large datasets. 4

Mixed methods research —This form of research incorporates both quantitative and qualitative methodologies.

Systematic reviews —These provide a summary of the known evidence base around a particular research question. They often create new data by combining other quantitative (meta-analysis) or qualitative (meta-ethnography) studies. They are often used to inform clinical guidelines.

Box 5: Stages of research projects

Project conception—Come up with a hypothesis or an objective for the project and form the main research team.

Write the research protocol—Produce a detailed description of the methodology and gain ethical approval, if needed.

Carry out the methodology by collecting the data.

Analyse the data.

Decide on the best way to disseminate your findings—for example, a conference presentation or a publication—and where you will do this.

Write up your work, including an abstract, in the format required by your chosen journal or conference.

Submit . For conference abstracts, you may hear back swiftly whether you have been offered the chance to present. Publication submissions, however, must be peer reviewed before being accepted and it can take over a year for a paper to appear in print.

Originally published as: Student BMJ 2017;25:i6593

Competing interests: AKT received grant money from INSPIRE in 2013.

Provenance and peer review: Not commissioned; externally peer reviewed.

• ↵ STARSurg. Student Audit and Research in Surgery. 2016. www.starsurg.org .
• ↵ NSAMR. National Student Association of Medical Research. 2016. www.nsamr.org .
• ↵ The Academy of Medical Sciences. About the INSPIRE initiative. 2016. www.acmedsci.ac.uk/careers/mentoring-and-careers/INSPIRE/about-INSPIRE/ .
• ↵ Ben-Shlomo Y, Brookes ST, Hickman M. Lecture Notes: Epidemiology, Evidence-based Medicine and Public Health. 6th ed . Wiley-Blackwell, 2013 .
• ↵ gp-training.net. Consultation Theory. 2016. www.gp-training.net/training/communication_skills/consultation/consultation_theory.htm .
• ↵ Reeves S, Kuper A, Hodges BD. Qualitative research methodologies: ethnography. BMJ 2008 ; 337 : a1020 . doi:10.1136/bmj.a1020   pmid:18687725 . OpenUrl FREE Full Text
• ↵ Porta M. A Dictionary of Epidemiology. 5th ed . Oxford University Press, 2008 .

How to Conduct Research in Healthcare in 9 Steps

• March 13, 2023

Table of Contents

Conducting research is a complex and multi-step process. This guide will provide an overview of how to conduct healthcare research, including the steps involved and key considerations for each stage.

1: Define the Objectives of Your Research Study

The objectives of the research study should include both short-term and long-term goals . It is essential to have a solid plan with well-defined objectives and the right methods to ask the right questions to the right people. 

Research should also consider ethical issues and the steps needed to minimize harm to those who take part. Furthermore, potential benefits to users must be considered, and it’s important to include time frames, milestones, and communication strategies.

Analyze and interpret data collected from surveys or interviews to identify trends related to the impact on desired outcomes, such as changes in attitudes or behaviors over time and changes in policies or practices.

2: Identify Relevant Studies and Sources

Searching the literature helps ensure that the research will address an appropriate gap in the evidence and help refine the research question and choice of methods. Critiquing the methodology of other people’s work is key to building up a better understanding and justification for a research approach.

The search strategy can be developed and enriched using relevant terms and literature from MeSH , Medline Plus , Ovid MEDLINE, EMBASE , CINAHL , HMIC , and Oxford Academic’s Research Evaluation databases. 

Screen all retrieved citations for eligibility based on your inclusion criteria and discard any that do not meet them (e.g., non-English language articles). Review the remaining articles for quality using appropriate assessment tools (e.g., QUADAS ).

Lastly, apply systematic review methodology (e.g., PRISMA ) to ensure transparency in reporting findings from each study reviewed in your review article or paper report.

? Learn more: Common Data Sources in HEOR

3: Consider Ethical Approval and Consent Requirements

Research teams should follow ethical guidelines and seek approval from a research ethics committee for their plan. The research should not involve any unnecessary harm or risk to the participants, and all possible measures should be taken to ensure their welfare and safety during the study period.

In addition, studies involving new medicines should have gone through a process to ensure they are ready for use with people before being tested on humans or animals in clinical trials or laboratory experiments, respectively.

Consent should also be obtained from all participants before they take part in the study, outlining what they can expect from it as well as any potential risks involved in taking part in it (if any).

4: Create a Study Plan and Timeline

After identifying the topic and research question, you would like to explore and review the eligibility criteria for each registry or study , as well as any additional requirements, such as consent forms or surveys, to determine which ones are suitable for your project goals and needs. 

Select one or more registries or studies that fit your needs best, then register with them if necessary by following their instructions on how to participate in their study.

Don’t forget to create a timeline for how long you will be involved in each study so you can keep track of progress toward completion of the project goals.

5: Construct a Questionnaire or Survey

Identify the purpose of the research and the target population and determine what information you are trying to gather, as well as who will be most affected by your research.

Create a survey or questionnaire that includes questions that are relevant to your purpose and can be answered by respondents in a way that is meaningful to them. Make sure it is clear, concise, and easy to understand for all ages and levels of education and language abilities.

Pilot-test your survey with a small group of people from your target population before rolling it out across the board for full use in research activities (e.g., interviews).

Finally, analyze responses using descriptive statistics (e.g., mean scores) or inferential statistics (for example, t-tests) as needed depending on what questions are being asked of participants in order to understand their experiences better or make comparisons between groups if applicable.

? Related: Biostatistics in HEOR

6: Write Your Research Proposal

The process of writing a research proposal can be broken down into six manageable steps.

• Introduce an educated idea arising from a clinical practice issue . The research topic should be rooted in a problem that affects medical practice; it should also provide motivation for completing the research and relevance for affecting medical practice changes and improvements.
• Conduct a systematic literature review before starting to write . This will help to inform the research idea and provide evidence to support the project from the beginning.
• Develop a conceptual framework . This will help to clarify the research question and ensure the proposed project is feasible and efficient.
• Seek advice from clinical experts, experienced researchers, relevant stakeholders , and even patients. This will enhance the research question’s relevance, feasibility, and efficiency in your document.
• Structure the research proposal . It should include background, objectives, methodology, outcomes, and dissemination. Additionally, include a section on ethical issues, service user involvement, and project management.
• Proofread the proposal carefully before submitting it to a funding body or ethical review panel. Consider having the proposal read by a consumer of health, colleague, or friend to ensure clarity and that jargon would be understood by a wider audience.

7: Collect Data Manually or Electronically

Determine the end goal of your research project and decide whether qualitative or quantitative data collection methods would be most beneficial for achieving your goal.

Select appropriate data collection methods, such as interviews, focus groups, observation for qualitative research, multiple choice surveys, or structured data analysis for quantitative research.

Analyze the collected data using specific tools and methods relevant to each data collection method (e.g., qualitative analysis software). This step should be done thoroughly to draw valid conclusions from the findings.

8: Elaborate on Conclusions and Report Results

First, identify the purpose of the research study and determine which outcomes are most relevant . Next, plan how to communicate results to study participants , including what information to provide, when it should be provided, and how it should be presented.

When possible, involve patients or other individuals who have participated in the study in developing feedback mechanisms that are meaningful to them.

At a minimum, provide participants with a summary of findings from their records that are clinically relevant (as determined by researchers) as well as an explanation of these findings in an understandable format.

In addition, you can consider providing additional information, such as data tables or graphs showing trends over time if applicable; this may help individuals better understand their healthcare situation more clearly. You can also provide opportunities for further discussion if needed.

9. Disseminate Your Findings

Depending on the size and scope of your research, disseminating your research could include media releases and interviews, conference presentations and posters, white papers, policy briefs, infographics, or other formats.

Follow best practices when communicating your findings. Consider the National Institutes of Health Guide, A Checklist for Communicating Science and Health Research to the Public , for tips on making research results accessible to a broad audience. 

Additionally, the Rural Health Research Gateway’s Dissemination Toolkit provides examples of fact sheets, policy briefs, and other dissemination formats, as well as general guidelines for sharing rural health research findings.

By taking the previous steps, you can ensure that your research is accurate and comprehensive and can be communicated thoroughly to all stakeholders. This will give you the confidence to present your findings in a meaningful way and disseminate them to the appropriate audiences.

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Medical Research

How to conduct research as a medical student, this article will address how to conduct research as a medical student, including details on different types of research, how to go about constructing an idea and other practical advice., kevin seely, oms iv.

Student Doctor Seely attends the Rocky Vista University College of Osteopathic Medicine.

In addition to good grades, test performance, and notable characteristics, it is becoming increasingly important for medical students to participate in and publish research. Residency programs appreciate seeing that applicants are interested in improving the treatment landscape of medicine through the scientific method.

Many medical students also recognize that research is important. However, not all schools emphasize student participation in research or have associations with research labs. These factors, among others, often leave students wanting to do research but unsure of how to begin. This article will address how to conduct research as a medical student, including details on different types of research, how to go about constructing an idea, and other practical advice.

Types of research commonly conducted by medical students

This is not a comprehensive list, but rather, a starting point.

Case reports and case series

Case reports are detailed reports of the clinical course of an individual patient. They usually describe an unusual or novel occurrence or provide new evidence related to a specific pathological entity and its treatment. Advantages of case reports include a relatively fast timeline and little to no need for funding. A disadvantage, though, is that these contribute the most basic and least powerful scientific evidence and provide researchers with minimal exposure to the scientific process.

Case series, on the other hand, look at multiple patients retrospectively. In addition, statistical calculations can be performed to achieve significant conclusions, rendering these studies great for medical students to complete to get a full educational experience.

Clinical research

Clinical research is the peak of evidence-based medical research. Standard study designs include case-controlled trials, cohort studies or survey-based research. Clinical research requires IRB review, strict protocols and large sample sizes, thus requiring dedicated time and often funding. These can serve as barriers for medical students wanting to conduct this type of research. Be aware that the AOA offers students funding for certain research projects; you can learn more here . This year’s application window has closed, but you can always plan ahead and apply for the next grant cycle.

The advantages of clinical research include making a significant contribution to the body of medical knowledge and obtaining an understanding of what it takes to conduct clinical research. Some students take a dedicated research year to gain experience in this area.

Review articles

A literature review is a collection and summarization of literature on an unresolved, controversial or novel topic. There are different categories of reviews, including meta-analyses, systematic reviews and traditional literature reviews, offering very high, high and modest evidentiary value, respectively. Advantages of review articles include the possibility of remote collaboration and developing expertise on the subject matter. Disadvantages can include the time needed to complete the review and the difficulty of publishing this type of research.

Forming an idea

Research can be inspiring and intellectually stimulating or somewhat painful and dull. It’s helpful to first find an area of medicine in which you are interested and willing to invest time and energy. Then, search for research opportunities in this area. Doing so will make the research process more exciting and will motivate you to perform your best work. It will also demonstrate your commitment to your field of interest.

Think carefully before saying yes to studies that are too far outside your interests. Having completed research on a topic about which you are passionate will make it easier to recount your experience with enthusiasm and understanding in interviews. One way to refine your idea is by reading a recent literature review on your topic, which typically identifies gaps in current knowledge that need further investigation.

Finding a mentor

As medical students, we cannot be the primary investigator on certain types of research studies. So, you will need a mentor such as a DO, MD or PhD. If a professor approaches you about a research study, say yes if it’s something you can commit to and find interesting.

More commonly, however, students will need to approach a professor about starting a project. Asking a professor if they have research you can join is helpful, but approaching them with a well-thought-out idea is far better. Select a mentor whose area of interest aligns with that of your project. If they seem to think your idea has potential, ask them to mentor you. If they do not like your idea, it might open up an intellectual exchange that will refine your thinking. If you proceed with your idea, show initiative by completing the tasks they give you quickly, demonstrating that you are committed to the project.

Writing and publishing

Writing and publishing are essential components of the scientific process. Citation managers such as Zotero, Mendeley, and Connected Papers are free resources for keeping track of literature. Write using current scientific writing standards. If you are targeting a particular journal, you can look up their guidelines for writing and referencing. Writing is a team effort.

When it comes time to publish your work, consult with your mentor about publication. They may or may not be aware of an appropriate journal. If they’re not, Jane , the journal/author name estimator, is a free resource to start narrowing down your journal search. Beware of predatory publishing practices and aim to submit to verifiable publications indexed on vetted databases such as PubMed.

One great option for the osteopathic profession is the AOA’s Journal of Osteopathic Medicine (JOM). Learn more about submitting to JOM here .

My experience

As a second-year osteopathic medical student interested in surgery, my goal is to apply to residency with a solid research foundation. I genuinely enjoy research, and I am a member of my institution’s physician-scientist co-curricular track. With the help of amazing mentors and co-authors, I have been able to publish a literature review and a case-series study in medical school. I currently have some additional projects in the pipeline as well.

My board exams are fast approaching, so I will soon have to adjust the time I am currently committing to research. Once boards are done, though, you can bet I will be back on the research grind! I am so happy to be on this journey with all my peers and colleagues in medicine. Research is a great way to advance our profession and improve patient care.

 Keys to success

Research is a team effort. Strive to be a team player who communicates often and goes above and beyond to make the project a success. Be a finisher. Avoid joining a project if you are not fully committed, and employ resiliency to overcome failure along the way. Treat research not as a passive process, but as an active use of your intellectual capability. Push yourself to problem-solve and discover. You never know how big of an impact you might make.

Disclaimers:

Human subject-based research always requires authorization and institutional review before beginning. Be sure to follow your institution’s rules before engaging in any type of research.

This column was written from the perspective from a current medical student with the review and input from my COM’s director of research and scholarly activity, Amanda Brooks, PhD. 

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Tips on surviving—and thriving—during your first year of medical school

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How to Conduct Research During Medical School

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Most med schools in the United States require that you participate in some sort of scholarly project. Participation in the academic life of medicine is a great way to enhance your residency applications, and it may even be expected or required to successfully match in the most competitive specialties.

Traditionally, medical student research took the shape of a formal research opportunity in a research lab with a research mentor, culminating in a publication. Today, research in medical school takes a variety of forms, including the traditional one.

Beyond the typical lab format, medical students engage in scholarship by conducting poster presentations, writing up case presentations of interesting diseases they have encountered on the wards, or participating in quality improvement initiatives or other health systems science projects. All of these scholarly pursuits fall under the broad category of “research”, which may be required during medical school, and all contribute to the strength of a student’s residency application. 

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Is It Even Possible to Do Research in Medical School? 

With all the day-to-day challenges of medical school, it can be difficult to see where time for research fits in. With good planning and time management, however, you can include research in medical school. While fulfilling your clerkship requirements, studying and passing exams and courses, and taking care of patients are all top priorities, carving out time for research is certainly a possibility, especially on lighter rotations and with the udicious use of elective time. 

Many medical schools now offer a dedicated research period for you to engage in scholarship. Depending on the project, this period may be more or less time than you need to complete your research. You should check to see if your school offers dedicated time for research, and when it is.If you do have a dedicated research block, checking with your school about the expectations for deliverables at the end of the time period, as well as whether the block is structured or unstructured, will help you to make the most of this block.

If your school does not offer a specific time period for research and you anticipate needing to work on a project full-time, using elective time for research or scheduling research during lighter rotations can be a great way to make the time you need for research. 

When is the best time to do research in medical school? 

For many medical students, especially those applying to highly competitive specialties, you’ll want to start thinking about when to do research in medical school early in your academic career. If you know you have specific research or subspecialty interest going into medical school, start looking for a research project or mentor as soonas possible. This will maximize your chances of completing published research by the time you need to apply for a residency program.

If you are not sure about research or aren’t interested in conducting research at all, waiting until closer to your residency application and choosing an interesting case or project to present as a case conference or poster may make more sense. If you do intend to publish a paper or complete a large scholarly project, make sure you start early so that your project is complete in time for residency applications, recognizing that not every project results in a publication. For larger projects, it makes sense to have identified a research mentor and to start working on your project sometime before the beginning of your second year.

Keep in mind that the publication process of peer review and article revisions can take longer than anticipated, and your article may not appear in print until several months after you submit your abstract.

Smaller projects, such as a case vignette or poster presentation, typically have a much faster turnaround time – usually only a few months from project inception to presentation, depending on the venue where you present. 

Do you have to do research in medical school?

Even for physicians in training who have no desire to do research after medical school, research can be a useful way to build skills that will be helpful in their future career. For instance, a student interested in hospital medicine might use the research time to complete a quality improvement project on reducing the risk of infections acquired in a hospital, which in turn might help them in a future role as a medical director.

A future general surgeon might decide to use the research time to get an MBA, helping them gain the business skills necessary to run a successful independent practice. A prospective infectious disease specialist might conduct a public health study that gets them comfortable with interpreting statistics, which could be beneficial when running a local health department.

Students who are not interested in staying in academics after graduation but are required to do research should make use of dedicated research time to build skills that they can apply outside of the academic world. 

How to Do Research as a Medical Student

Every good research project starts with a question. You’re far more likely to stay engaged in research, and to produce a good research product, if you have a real interest in the question your project aims to answer. Once you’ve identified a question you hope to answer, ask your professors, attending physicians, and even other classmates if they know of anyone working on a similar question.

While you might not identify someone working on exactly what you are interested in, you’ll likely find someone with similar interests who can direct you to someone who is well-aligned with your interests. Once you identify a research mentor, it’s up to you to determine what your goals are in doing research.

If you intend to publish a paper that appears in a top-notch medical journal, for instance, your research will probably require more time and effort than if you hope to do a case presentation of an interesting disease you encountered on rounds.

Try to tailor the scope of your project to the time you have available to complete it. “I want to cure cancer” is not a realistic goal for a research project to complete as a medical student, but working on a specific gene pathway with a goal of presenting a poster at a national conference might be! 

How to find research opportunities

Finding research opportunities as a medical student starts with identifying your area of interest. Do you have a subspecialty you are particularly fascinated by? If so, reaching out to an academic specialist in your area of interest is a great first step to finding research opportunities.

Fascinated by a particular case you saw on rounds? Ask your attending physician if they think the case might be appropriate for a poster presentation or to present at an academic conference. Not interested in writing up case reports or writing long research abstracts? Maybe an opportunity in quality improvement is right for you – ask your attending physicians if there are any hospital-level projects or initiatives which could benefit from some help.

Do you have a specific idea that you think could change the world? Try applying for a research grant or scholarship to help fund that opportunity and make it a reality. In many medical schools, and especially in those associated with academic research centers, the only limitations on research opportunities are those of your own imagination! 

How is medical research funded?

Most medical research projects conducted by medical students are not funded and occur on the side, with a student volunteering their time and effort toward a project. However, if you are planning on a more extensive project that would take you away from your normal studies for a year or more, there are a variety of foundations and funded research opportunities that you can use to support yourself during the time you are conducting your research.

Generally speaking, the best opportunity to engage in funded medical research is by enrolling in a combined MD/PhD program.

If you are interested in a specific field of study and want to have protected, dedicated time to engage in medical research prior to residency, a combined MD/PhD program will give you the best balance of clinical and research training. However, MD/PhD programs are highly selective and are not available at every medical school.

You can learn more about combined degree programs on the AAMC website . The American Physician Scientists Association also maintains a list of funding opportunities for MD/PhD candidates on their website.  

To Sum It Up…

Spending some time engaging in research during medical school can be rewarding, both personally and professionally. Although opportunities to engage in traditional research abound in medical school, students who are not interested in this can explore alternatives to traditional research, like case presentations, quality improvement projects, or even dual degree programs like an MBA. Pursuing research in any of these forms can be a great way to improve your residency application and help you develop the skills you need to succeed long after medical school.

Dr. Brennan Kruszewski is a practicing internist and primary care physician in Beachwood, Ohio. He graduated from Emory University School of Medicine in 2018, and recently completed his residency in Internal Medicine at University Hospitals/Case Western Reserve University in Cleveland. He enjoys writing about a variety of medical topics, including his time in academic medicine and how to succeed as a young physician. In his spare time, he is an avid cyclist, lover of classical literature, and choral singer.

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How to Get Research Experience

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Working in a research setting can help make you a competitive medical school applicant and help you to determine if a career in medicine or medical research is right for you

How do I find a research position?

If you’re currently in college, check with your institution’s science or undergraduate research websites for opportunities to assist with faculty research projects. You can also review faculty bio pages and lab websites for more information. Next, reach out to your immediate network: express your interest in assisting with a research project to your science professors, academic advisor, and your pre-health advisor.

Try exchanging ideas with your peers and upper-classmen for advice on research opportunities at your institution. You can also ask peer advisors, resident advisors, or any fellow premedical students for introductions to principal investigators (PIs). You might even try the “Undergrad-Grad-PI” method. This is where you first reach out to undergraduate students in research labs to learn about their responsibilities; they oftentimes are more responsive. Then, reach out to the graduate or post-doc students to learn about the research question being investigated. After this, read the most recent paper or abstract the lab published. Once you complete these steps, you can approach the PI more confidently and more effectively demonstrate your commitment to and understanding of their project.

Your school’s career center or student employment office may know about research job openings, and they can also offer resume help and go over interview tips and techniques. Remember, opportunities may be on or off campus, full- or part-time, paid or unpaid, or part of a summer program. Once you find a position, you can connect with your school’s fellowships or awards office to inquire about research funding opportunities.

If you’ve already graduated, consider looking into open positions. Research hospitals, universities, and biotech companies are always looking for lab technicians or clinical research coordinators (CRC). Job opportunities are typically posted on the career pages of their websites.

When should I begin gaining research experience in college?

Some premedical students begin their research experiences during their first year of college, and others begin research positions after they have already graduated. On average, most students secure a research position junior or senior year. There are three big factors that will impact this:

• Your level of interest in pursuing research. If you are really excited to investigate a question under a mentor, you might find yourself reaching out to professors early and often. Other students may focus on gaining clinical experience, and therefore wait later in their academic career to start research.
• Readiness for the research project. Different PIs will have different expectations for preparation. A research project might require you to first take coursework in basic lab sciences, statistics, or another advanced topic specific to the project. Other PIs may prefer to train you “on-the-job” through their graduate or post-doc students. This will impact when you are ready to join a project.
• Finding the right research project. There is a process of reviewing different PIs and research projects to find the right fit for you. What subject do you want to investigate? Do you want your research project to take place in a lab or non-lab setting? Is there an independent question you want to investigate with the help of a mentor?

When is the best time to look for a position?

According to Kate Stutz, Ph.D., Director of Pre-Health Advising at Brandeis University, if you’re interested a research position during the academic year, the best time to look for positions is at the very beginning of the semester. There also tend to be a lot of research opportunities in the summer, both paid and volunteer, through set programs like the National Science Foundation’s Research Experience for Undergraduates (REUs). It’s best to start applying for summer research positions in December-February for the upcoming summer. Remember, typically there are more applicants than available spots so get your applications in early. Each undergraduate institution will be different, therefore make sure to connect with your advisors and peers for feedback on when to start looking.

What’s the best way to apply?

The outreach email message that you send to potential research faculty is very important. This message should include a formal introduction of yourself, evidence that you are familiar with their research project(s), and a clear, specific ask. Identify what you hope to contribute to the project. Do you want to clean the glassware or analyze lab findings? Consider attaching your resume as well. Dr. Stutz stresses that networking and persistence are crucial to finding a position. Make sure you’re using all of your network, including your peers and professors, to find open positions. Don’t be afraid to send follow up emails; faculty are very busy and often overlook emails. Sometimes, it can be even more effective to stop by a professor’s office hours to hand deliver your materials and indicate your interest in person.

How should I prepare for an interview?

With any interview, it’s important to make a good impression. Be sure to dress appropriately. Come prepared with a resume. Use your campus career center for advice on proper attire and resume best practices.

Often during interviews, you’ll be asked about your career goals. It’s helpful to be able to speak about the steps you plan to take to meet those goals. Talk about classes you’ve taken, especially upper-level science courses. Speak about your skills, your knowledge of techniques, and the equipment you’ve used throughout your coursework. Be prepared to discuss the lab experiments you’ve completed. If you’ve done any sort of research—even in your coursework—keep track of it. This shows you have experience. Lastly, interviewers often ask candidates if they have any questions. Dr. Stutz suggests asking something that indicates you’ve done your own research into their project. You could ask where they see their research going in the next three years or what challenges they anticipate. You could also ask about expectations for undergraduate researchers; do they expect you to work 20+ hours a week? Full time over the summer? Do they require you to have work study or to sign up for research credits? Asking these questions ahead of time can help you plan ahead and determine if this position is the best fit for you. Check out these  interview resources  for more tips.

Does research experience have to be in a wet lab?

No! Research can be performed in any field or subject. We’ve had successful applicants with research in classics, sociology, history, and policy, as well as applicants with research in biology, biochemistry, and neuroscience. Medical schools value all types of research. Research can take place in a scientific lab that requires advanced devices and procedures to obtain data for analysis. Research can also take place in the humanities or social sciences where participant interviews or surveys are needed to obtain an individual's life perspective. The clinical research field is constantly investigating patient outcomes and how to improve care through clinical trials or analysis of patient data. As a premedical student, consider what question you want to investigate further. Do you want to learn more about how health inequities impact disadvantaged communities in your area, or perhaps you want to know more about the protein channels involved in memory cognition? Once you choose a direction, you can then partner with a research PI for guidance on how to navigate your question. Sierra Perez, Pre-Health Advisor at Brandeis University, shares not to be afraid to get creative with your research question. She has been impressed by the medical school applicants who have created independent questions that address the community needs. “Applicants are recognizing the critical needs of specific populations, such as homelessness, LGBTQ+, veterans, youth with disabilities, etc.,” she stated. “There is also a demand for translational researchers, or individuals who can take complicated bench topics and apply it to the clinical world.”

Is research experience required to be accepted to medical school? 

It depends. Some medical schools are very research focused; they may require a research thesis or have research time built into the curriculum. Other schools are more community or clinically focused; they would rather have an applicant work in a healthcare setting or volunteer at their local soup kitchen than be at the bench moving clear liquids from one test tube to another. Research experience (in whatever discipline) is helpful for developing some of the AAMC Core Competencies , such as critical thinking, quantitative reasoning, scientific reasoning, as well as teamwork and oral communication skills. How much you should engage in research depends on how much you enjoy it once you try it!

The majority of accepted medical school applicants have some form of academic or clinical research at the time they apply. Competence in research has become increasingly important in the medical field to improve patient care outcomes.

You can also review medical school mission statements to see if research is a focus at a particular school. You can read each school’s mission, and the number of accepted students in their most recent class who had research experience, in the  Medical School Admission Requirements . Remember, it’s best to pursue experiences that you’re genuinely interested in, rather than just to check a box, but you may not know if research is for you until you give it a try.  

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Premed Research That Impresses Medical Schools

Here are at least six research areas where you can leverage experiences to stand out on your medical school applications.

Research that Impresses Medical Schools

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When writing about research on applications, describe not only what was done, but also write what was learned through research experiences.

One question premedical students frequently ask is, “Do I need to do research in order to be competitive for medical school ?” 

My short answer: No.

It's not necessary for a medical school applicant to be involved in research , let alone publish a paper, in order to have a strong application. However, research only strengthens one’s application and never hurts it. Research doesn't guarantee acceptance to a medical school, and it's not necessary to gain acceptance.

However, I encourage premed students to conduct research at some point during their premed careers. Being involved in a research project trains premeds to think critically about an unresolved problem.

Research allows us to gain a better understanding of the unknown. Our current medical knowledge is built on clinical research . Drugs we prescribe patients underwent rigorous clinical trial studies, for example, and diagnostic work-up and treatment plans rely on evidence-based medicine based on research data.

Many premed students think that the research they conduct needs to be medical or scientific in nature. Another common misconception is that a strong premed must be involved with basic science research, often called bench research. While many premeds conduct medical-related research, these beliefs are not true. I have mentored amazing premed students with research ranging from Shakespearean play analysis to the creation of medical devices for individuals with disabilities.

6 Types of Medical Research

Here are six common health-related research directions I commonly see among premeds that reflect the breadth of research you can pursue:

• Basic science research
• Clinical research
• Public health research
• Health public policy research
• Narrative medicine research
• Artificial intelligence research

Basic Science Research

Basic science research, often called “bench research,” is the traditional research conducted in a laboratory setting. It tackles our fundamental understanding of biology .

Premeds involved with basic science research often study cells, viruses, bacteria and genetics. This research may also include animal and tissue specimens.

Examples: A premed student interested in cancer biology may study the cellular pathway of a specific tumor suppressor gene. Another premed student may probe how gut bacteria affect protein folding.

Clinical Research

Clinical research is the arm of medical research that tests the safety and effectiveness of diagnostic products, drugs and medical devices. It involves human subjects.

Examples: A premed interested in COVID-19 may conduct clinical trial research on new COVID-19 treatments. Another premed interested in dementia studies whether sleep improves depression among Alzheimer’s patients.

Public Health Research

Public health research studies the health of communities and populations in order to improve the health of the general public. Topics can range from vaccine access, disease prevention and disease transmission to substance abuse, social determinants of health and health education strategies.

Examples: A student interested in health equity may conduct public health research on how health insurance status and geography affect heart attack mortality. A premed excited about environmental science may look at the health impacts of wildfire smoke.

Health Public Policy Research

Premeds engaged in health policy research aim to understand how laws, regulations and policies can influence population health. Premeds may engage in both domestic and global policy research.

Examples: A premed interested in nutrition researches the effectiveness of nutrition programs in the Philippines. Another premed interested in economics studies health insurance markets in America.

Narrative Medicine Research

Narrative medicine research involves gathering stories from patients and their loved ones in order to understand the patient experience. As noted on the Association of American Colleges website , “Those stories can illuminate how a person became ill, the tipping point that compelled them to seek help, and, perhaps most importantly, the social challenges they face in getting better.”

Examples: A premed student interested in how Asians perceive disease can interview Asian patients about their attitudes toward herbal medications in cancer treatments. Another premed student interested in caregiver support can interviews caregivers of patients on prolonged mechanical ventilation to understand families’ decision-making processes.

Artificial Intelligence Research

Medical research utilizing artificial intelligence is increasingly popular, and premeds can analyze a large set of information to find medical discoveries. Premeds who conduct AI research typically have a skillset in computer science.

Examples: A premedical student interested in radiology may use AI to analyze hundreds of chest X-rays to create a program that better detects pneumonias. Another premed student may create and refine an algorithm using EKGs to better pick up abnormal heartbeats.

Remember that research not limited to these six categories. I've also met premeds engaged in journalistic research and business consulting research. As long as you have a research question and a scientific approach to analyze the question, then your pursuit can usually be considered research.

How Research Can Strengthen Medical School Applications

Research can strengthen your medical school application in several ways.

First, when a research project is related to a student’s interests, research involvement shows the application committee that the student is committed to advancing that field .

When writing about your research on applications, not only describe what you did, but also write what you learned through your research experiences. These lessons can include adaptability, analytical thinking and resilience.

Furthermore, you can discuss research through writing stories on secondary applications . For example, a common secondary essay prompt asks you to discuss a time when you failed or faced a challenge. You can write an essay about a challenging time you faced in your research and discuss how you overcame it. This will allow the admissions committee to gain insights into how you critically think through a problem.

Second, medical schools greatly favor independent research, in which students are leading the projects. In independent research, a premed forms a research question and a hypothesis. Then, the student gathers, analyzes and interprets data.

A student conducting independent research is in contrast to a student who helps another researcher with part of a project, or a student who follows protocols such as clinical trials recruitment, without thinking critically through the research design and analysis.

Third, becoming an author on a published paper can be a significant milestone and a valuable boost for a premed’s application. Of course, being a first author on a manuscript is an excellent feat, but it is not necessary for being seen as a strong student.

Other than publishing in academic journals, premedical students can showcase their research through poster presentations and talks. Presenting research conveys that you are excited about sharing your work and that you can explain your research to others, even those outside your field. These are all strong ways to indicate achievement and passion related to research.

The Value of Research for Premeds

Conducting premed research can provide firsthand insight into how much research you want to pursue throughout your career. After conducting research, some students may decide to get an M.D.-Ph.D. joint degree. Other students may come to the realization that their strengths lie elsewhere and conduct minimal research as doctors.

Through research, aspiring physicians will develop important skills that will help them in patient care. They will learn how to read and write research papers and evaluate treatment options by analyzing how robust the evidence is toward a specific treatment.

There are many advantages of engaging in research as a premed, only one of which is improving your medical school application. Since research is the cornerstone of medical advancement, research can help you become a more thoughtful doctor.

Medical School Application Mistakes

Tags: medical school , research , graduate schools , education , students

About Medical School Admissions Doctor

Need a guide through the murky medical school admissions process? Medical School Admissions Doctor offers a roundup of expert and student voices in the field to guide prospective students in their pursuit of a medical education. The blog is currently authored by Dr. Ali Loftizadeh, Dr. Azadeh Salek and Zach Grimmett at Admissions Helpers , a provider of medical school application services; Dr. Renee Marinelli at MedSchoolCoach , a premed and med school admissions consultancy; Dr. Rachel Rizal, co-founder and CEO of the Cracking Med School Admissions consultancy; Dr. Cassie Kosarec at Varsity Tutors , an advertiser with U.S. News & World Report; Dr. Kathleen Franco, a med school emeritus professor and psychiatrist; and Liana Meffert, a fourth-year medical student at the University of Iowa's Carver College of Medicine and a writer for Admissions Helpers. Got a question? Email [email protected] .

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Top 10 Medical Research Project Ideas for High School Students

By Jordan Ellington

Project Support Manager at Polygence

4 minute read

The field of medicine is constantly growing and changing and there are always new challenges for researchers to tackle. Think back to the progression of COVID-19 and how it started with diagnosis after diagnosis but no treatment or end in sight. Thanks to research, clinical studies, and technological advancements, we now have readily-available vaccinations. Whether medical researchers are working to improve treatments or to create new ones, there's always work to be done.

If you are fascinated by the advancement of medicine and passionate about healthcare topics as a high school student, this could be a great opportunity for you to explore and learn more about it through an independent research passion project ! Our medical and healthcare mentors compiled a  list of 10 intriguing medical and healthcare research project ideas to inspire you. If any of these pique your interest, sign up to get matched with a mentor and get started on your student research project !

Medical Project Ideas to Kick Off Your Research

1) the use of virtual and augmented reality in medicine.

Level: Beginner

Virtual realities are becoming the norm around households and even classrooms these days! Did you know that virtual and augmented realities are also starting to be incorporated within the world of medicine ? Take a deeper dive into this topic and write a research paper on your findings!

Idea by medical research mentor Mina

2) High School Health Independence

Level: Beginner 

Sometimes, it’s hard for teens to pinpoint a medical problem that they might be facing. How can we better educate high schoolers on the ins and outs of self care and living a healthy life? Brainstorm ways to introduce positive lifestyle mechanisms to this specific age group. 

Idea by medical research mentor Margaret

Research YOUR fave areas of Biology and Medicine

Polygence pairs you with an expert mentor in to create a passion project around biology and medicine. Together, you work to create a high quality research project that is uniquely your own. We also offer options to explore multiple topics, or to showcase your final product!

3) How Does Aristotle Inform Decision-Making at the End of Life in the U.S. Healthcare System?

Sometimes, medical decisions can interfere with what you believe is ethically correct. To help with this, clinicians should have some sort of guide to help them through decision making processes. For this project, you will grasp a better understanding of Aristotle’s principles, ethics, and more to assist with medical decision making . 

Idea by medical research mentor Avery

4) A Review of How Genomics Has Transformed Medicine

Cancer treatments are now being personalized and it’s largely due to genomics! Take time to do your research and explore genomics and all of the advances it has allowed us to reach. 

Idea by medical research mentor Trudy

5) What can Songbirds Teach us About Premature Infants? 

Level: Intermediate 

Due to the advancement of medicine, more premature babies are given a chance at life than ever before. However, some of these babies unfortunately grow to develop some sort of mental impairment which points back to their time spent in the NICU. Is NICU sensory overload altering brain development?

Idea by medical research mentor Naomi

6) Under the Dermatoscope: A Fact Check of Common Skin Care and Sun Protection Advice

If you find yourself buying lotions and serums to protect your skin from the sun, this could be the project for you! Do your research on all things dermatology! What really causes skin damage and how do you know you’re using the correct ointments? Create a blog or podcast on skin health. 

Idea by medical research mentor Austin

Dive in to BioMed NOW!

Register to get paired with one of our expert mentors and to get started on exploring your passions today! You have agency in setting up your schedule for this research. Dive in now!

7) Development of New Cancer Treatment with Targeted Medicine

Level: Advanced 

Explore the world of medicine by helping treat a cancer type of your choice! For this project you will invent a drug by learning more about cancerous cellular markers . You will focus on targeting those specific markers with the drug that you develop. Write a research paper or create a poster presentation to explain your creation. 

Idea by medical research mentor Clayton

8) How will Personalized Medicine Affect the Costs of Medical Care?

Imagine you went to the doctor and used your insurance, yet, you still received a large bill in the mail. Better yet, you have to go back to the doctor because the treatment given to you didn't work. It’s time to incorporate personalized medicine into our healthcare system. Do your research to gain an understanding on why this has yet to happen and what we should do to get there. 

Idea by medical research mentor Alejandro

9) Pitch Me a Med Device Startup!

When COVID came, we were forced to adapt to a world of social distancing. Long gone are the days when we have to physically show up to a doctor's appointment! Zoom telehealth appointments are all the hype nowadays, whether you are suffering from the common cold or need to meet with your therapist. Determine a medical issue that does not yet have a remote checkup option available. Create a pitch to prove the needs of your app. 

Idea by medical research mentor Kyle

10) Tranexamic Acid as a Treatment for Drug-Induced Angioedema

Unfortunately, we probably all know someone with high blood pressure as it’s one of the most common diagnoses in the U.S. Even though there are plenty of medications that help control the spike in blood pressure, many of them have awful side effects. One of the most common side effects, angioedema , can be very dangerous if left untreated. Do your research to develop a treatment plan for these patients. 

Idea by medical research mentor Gaurav

Independent High School Research Project About Medicine and Healthcare

If you’d like to take part in a dedicated medical research program for high school students, Polygence can help! Explore some of our previous medical research projects and public health and learn more about how to get started on a high school student research project based on your unique interests!

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Get Matched with a Mentor

Interested in doing one of these exciting research projects? Click below to get matched with one of our expert mentors!

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Clinical trials: A significant part of cancer care

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Editor's note: May is National Cancer Research Month.

By Mayo Clinic staff

A cancer diagnosis is an emotional experience. Learning that you have cancer can create feelings of hopelessness, fear and sadness. This is especially true if your cancer is advanced or available treatments are unable to stop or slow its growth.

"Often, when patients are diagnosed with cancer , they feel hopeless and scared. Clinical trials are one way patients can be proactive. They can make a choice in how their care is going to be," says Matthew Block, M.D., Ph.D. , a Mayo Clinic medical oncologist.

Cancer clinical trials help physician-scientists test new and better ways to control and treat cancer. During a clinical trial, participants receive specific interventions, and researchers determine if those interventions are safe and effective. Interventions studied in clinical trials might be new cancer drugs or new combinations of drugs, new medical procedures, new surgical techniques or devices, new ways to use existing treatments, and lifestyle or behavior changes.

Clinical trials provide access to potential treatments under investigation, giving options to people who otherwise may face limited choices. "Clinical trials open the door to a new hope that maybe we can fight their cancer back and give them a better quality of life," says Geoffrey Johnson, M.D., Ph.D. , a Mayo Clinic radiologist, nuclear medicine specialist and co-chair of the Mayo Clinic Comprehensive Cancer Center Experimental and Novel Therapeutics Disease Group.

You will receive cancer treatment if you participate in a clinical trial. "I think one common misperception about clinical trials is that if you enter a clinical trial, you may not get treatment (receive a placebo). And that's actually very much not true. Most clinical trials are looking at one treatment compared to another treatment," says Judy C. Boughey, M.D. , a Mayo Clinic surgical oncologist, chair of Breast and Melanoma Surgical Oncology at Mayo Clinic in Rochester, Minnesota, and chair of the Mayo Clinic Comprehensive Cancer Center Breast Cancer Disease Group.

"I think one common misperception about clinical trials is that if you enter a clinical trial, you may not get treatment (receive a placebo). And that's actually very much not true. Most clinical trials are looking at one treatment compared to another treatment." Judy C. Boughey, M.D.

Watch this video to hear the experiences of people who have participated in cancer clinical trials and to hear Drs. Block, Johnson and Boughey discuss the importance of clinical trials in cancer care:

Clinical trials are a significant part of cancer care at Mayo Clinic Comprehensive Cancer Center. Cancer care teams work together across specialties to make sure the right clinical trials are available to serve the needs of people with cancer who come to Mayo Clinic.

"We are very particular in how we select the clinical trials that we have available for patients," says Dr. Boughey. "We want to have the best trials available for our patients. Some of the clinical trials are evaluating drugs — we are so excited about those drugs, but we can't prescribe those drugs for patients without having that trial. And so we will actually fight to try to get that trial open here to have it available as an opportunity for our patients."

If you choose to participate in a clinical trial, you will continue to receive cancer care. "For most patients that we evaluate, there's always the standard of care treatment option for those patients. And then, in many situations, there's also a clinical trial that the patient can participate in," says Dr. Boughey.

People who participate in clinical trials help make new and better cancer care available for future patients. The treatments available for cancer patients today exist because of the clinical trial participants of yesterday. "We couldn't advance medicine if it wasn't for people volunteering for trials. And the promise from our side is to say we're not going to put patients on trials or offer trials for them to consider unless we think there's a good chance that they'll get a benefit or that society at large will get a benefit," says Dr. Johnson.

"We couldn't advance medicine if it wasn't for people volunteering for trials. And the promise from our side is to say we're not going to put patients on trials or offer trials for them to consider unless we think there's a good chance that they'll get a benefit or that society at large will get a benefit." Geoffrey Johnson, M.D., Ph.D.

Participating in a clinical trial may give you access to cutting-edge treatment, improve your quality of life and extend your time with loved ones.

"It's definitely worth reaching out to your healthcare provider and asking, 'What clinical trials could I be a potential candidate for?'" says Dr. Boughey. "And remember, you can ask this of your surgical oncologist, your medical oncologist, your radiation oncologist, or any of the physicians you're seeing because there are trials in all disciplines. There are also ongoing trials that require the collection of tissue or the donation of blood. They can also be important in trying to help future generations as we continue to work to end cancer."

Participating in a clinical trial is an important decision with potential risks and benefits. Explore these FAQ about cancer clinical trials, and ask your care team if a clinical trial might be right for you.

Learn more about cancer clinical trials and find a clinical trial at Mayo Clinic.

Join the Cancer Support Group on Mayo Clinic Connect , an online community moderated by Mayo Clinic for patients and caregivers.

Read these articles about people who have participated in clinical trials at Mayo Clinic:

• A silent tumor, precancerous polyps and the power of genetic screening
• Mayo Clinic’s DNA study reveals BRCA1 mutations in 3 sisters, prompts life-changing decisions

Read more articles about Mayo Clinic cancer research made possible by people participating in clinical trials.

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When Patients Do Their Own Research

At its best, medicine will be a process of shared decision making, and doctors need to be prepared.

Listen to this article

Produced by ElevenLabs and News Over Audio (NOA) using AI narration.

Miscarriage early in pregnancy is very common—roughly one-fifth of detected pregnancies are thought to end in miscarriage, mostly in the first trimester. After a single miscarriage, patients are typically told that no further testing is needed; most women go on to have healthy pregnancies.

But after multiple miscarriages, doctors and patients begin a process of figuring out what is going on. In these situations, a lot of patients will take information gathering into their own hands. They’ll compile ideas from Google, WebMD, chat boards, support groups, friends, and friends of friends. Patients may arrive at their doctor’s office with file folders of information, cobbled-together ideas of their possibilities. Meanwhile, doctors have clinical knowledge, but they may struggle—especially given their limited time—to engage with their patients’ ideas and guide them.

Medicine wasn’t always this sort of shared process. Not long ago, medical decision making was largely left to doctors. Patients were a passive bunch, arriving at the doctor with their concerns and symptoms, and departing with their doctor’s orders. But today patients have incredible access to information online and elsewhere, and this has prompted a shift to what is sometimes called “shared decision making”: patients and doctors, together, sharing the burden of making consequential health choices.

Emily Oster: Thinking about pregnancy like an economist

This approach sounds great in principle. Shouldn’t patients be involved in decision making about their own health? In the area of obstetrics, the alternative brings to mind deliveries of the 1950s—white-coated doctors smoking cigarettes in their office while women labor in “twilight sleep,” even, in many cases, strapped to the bed. Surely if women had been involved, they would have opted for something a bit more comfortable.

In practice, though, shared decision making can be a source of frustration and confusion, for both sides. From the patient side, it can feel like doctors are either expecting too much engagement— Isn’t it your job to know what to do?— or not listening and not taking the patient’s ideas and preferences seriously. Sometimes it feels like all of this at once. From the medical side, frustration also comes in several forms—with patients who do not want to engage with the decision, and with those who do but are unwilling to listen to expert advice. Why won’t they listen to me? A patient who arrives with her own research can give the impression that she believes her Google search makes her an expert in medicine.

We, the authors of this article, come at this from both angles—one of us is a doctor, and one of us is an expert in statistics who has made a career of helping millions of pregnant people sort through data to make their own best decisions. We both believe that shared decision making in medicine can work, but many doctor-patient interactions today are not working. In our new book, The Unexpected , we try to provide a road map for improving this interaction, focusing on pregnancy. Our idea is simple. Two things are missing from this conversation: some common knowledge, and a script.

First, patients cannot engage with shared decision making if they do not understand the basics of their condition. To return to the example of miscarriage: A very large share of first-trimester miscarriages are a result of chromosomal abnormalities. If a patient does not know how chromosomes work in conception and what might influence them, discussing miscarriage prevention will be difficult. A patient doesn’t possess a doctor’s understanding of their condition—this would be unrealistic—but acquiring basic knowledge will allow patients to most effectively hear and process what is being said.

In particular, patients may benefit from getting a handle on the fundamental medical terminology associated with whatever symptoms they are presenting. Unfamiliar jargon can spark fear far beyond what one would feel if one knew what was being said. “Antiphospholipid antibody syndrome” sounds terrifying if you don’t know that, for many, it’s a treatable condition. When patients do not understand, many will shut down, unable to ask the questions they have or engage with the choices they need to make.

As a result, before doctors ask people to engage with decisions about their health, they need to prepare them. Our book tries to do this for people facing complicated pregnancy conditions. In other cases—cancer treatment, diabetes, other chronic illnesses—different resources exist. Patients should do some homework before they go to the doctor’s office.

The second thing these conversations need is a script. If patients and their doctor had limitless time to talk, then maybe it would be okay to enter the conversation with only a vague idea of the purpose. But time is limited, and that means a script is key, prioritizing questions where the answers matter for decisions.

To return to the miscarriage example, a script might start with the details of what happened. Knowing exactly when in pregnancy a loss occurred, what kind of testing followed it, and how many times it has happened will shape next steps. A second question is whether there are clues as to why it happened, which will inform whether it will happen again. A script might end by talking about what can be done to decrease risk, if anything.

Read: When evidence says no, but doctors say yes

In the best form of this conversation, the doctor brings a deep understanding of what might be going on medically with the patient, the range of possible tests, and what those tests might reveal to the patient. The patient brings a knowledge of their own preferences and their own emotional state. How much information do they want to know? Would they be willing to use more complex medical treatments if they were recommended? Are they even ready to engage emotionally with thinking about trying for pregnancy again?

The central recognition here is that shared decision making isn’t about both sides bringing the same thing to the table and deliberating about it. It’s about two different types of expertise—expertise in medicine on the part of the doctor, and expertise in herself on the part of the patient. Seeing this, in turn, can help the doctors and the patient both recognize when one decision maker should be paramount, or when a decision requires input from both.

An emergency situation—when, say, a person has been in a bike accident, his blood pressure is low, and he is bleeding from his head—isn’t the time for shared decision making. This is when the medical side takes over. No patient needs to be asked whether they think it’s a good idea to scan their head for a skull fracture. At the other end of the spectrum are decisions such as prenatal genetic screening and testing, which are in many cases almost exclusively about patient values and preferences.

Most decisions fall somewhere in between, requiring medical input but with room for patients’ preferences to play a role. Attempting a vaginal birth after a C-section is an example here—both a repeat Cesarean and an attempted vaginal birth have their risks and benefits. The medical expertise comes in explaining these risks and benefits, but the decision for many women here should come down to their own preferences.

With better understanding, clear scripts, and a sense of when different decision makers should dominate, we believe there is space for some decision making to be truly shared. But one more crucial element should be present: trust. Sometimes the desire by patients to play a role in their medical care can seem like a lack of trust in their doctors. And on the flip side, when patients do not feel like their concerns, ideas, or preferences are being listened to, they can lose trust in their provider to find what is best for them . Good decisions require the trust to recognize that we are all rowing in the same direction, and the willingness to engage so we can get there.

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After Her Death, Scientists Made This Woman Immortal. But She Never Agreed to That.

Her genetic material rewrote the future of medicine—all without her consent.

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In March 2024, Tuskegee University unveiled a monument commemorating Henrietta Lacks and her contributions to the fight against polio. Just days later, submissions closed for the Henrietta Lacks Hometown Initiative’s contest to design a memorial in her native Halifax County, Virginia.

It’s not surprising that Lacks, whose “immortal” HeLa cells were pivotal in developing treatments for diseases such as polio, HIV/AIDS, and COVID-19 , continues to be honored more than 70 years after her death. But Lacks’ legacy is complicated due to the ethical concerns surrounding the use of her special cells.

Lacks, who died of cancer at age 31 in 1951, was never aware that her cells led to significant medical advancements—or that they were taken without her consent. And even now, her strange case raises questions about the the morally dubious methods through which we achieved unquestionably positive breakthroughs in medicine.

The Immortal Life of Henrietta Lacks

Though her cells live on in labs across the world, Henrietta Lacks’ life was short and full of challenges, and she remained largely unrecognized during her lifetime. It wasn’t until author Rebecca Skloot investigated the origins of the famous HeLa cells that Lacks’ story gained widespread attention with the bestselling 2010 book, T he Immortal Life of Henrietta Lacks .

Thanks to Skloot and the descendants of Lacks, who have worked to retell her story through initiatives like HeLa100 , we now know more about the life of the woman often referred to as “the mother of modern medicine .”

On August 1, 1920, Lacks was born in Roanoke, Virginia. According to Biography , following her mother’s death in 1924, Henrietta moved to her grandfather’s log cabin, a former slave quarters on a plantation. There, she lived with her cousin, David “Day” Lacks. At 14, she gave birth to their first child, Lawrence, and the couple married in 1941. Before moving to Maryland, they had a second child, Elsie, in 1939, and later expanded their family with three more children: David Jr., Deborah, and Joe.

Henrietta had been experiencing “abnormal pain and bleeding in her abdomen” when she visited The Johns Hopkins Hospital in Baltimore on February 1, 1951. Lacks had to travel to Hopkins for treatment because, as Hopkins Medicine’s own website notes , at the time, the hospital “was one of only a few hospitals to treat poor African-Americans.”

Lacks was quickly diagnosed with cervical cancer by physician Howard Jones. She received radium treatments there, and without her consent, doctors extracted two cervical samples. Despite treatment, her condition worsened, leading to her readmission to the hospital on August 8. Lacks passed away on October 4, 1951, and was laid to rest in an unmarked grave in Clover, Virginia, where she spent her early years.

But unbeknownst to Lacks, or her family, the cervical samples taken without her consent revealed something extraordinary.

Lacks’ tumor cells were sent to the lab of Dr. George Otto Gey, a prominent cancer researcher. Gey collected cells “from all patients—regardless of their race or socioeconomic status—who came to The Johns Hopkins Hospital with cervical cancer,” according to the hospital’s website. But unlike previous samples that died within a day or two, Lacks’ cells amazingly doubled in number every 20 to 24 hours.

That discovery led to a medical revolution. As Biography summarizes:

“Gey isolated and multiplied a specific cell, creating a cell line. He dubbed the resulting sample HeLa, derived from the name Henrietta Lacks. The HeLa strain revolutionized medical research. Jonas Salk used the HeLa strain to develop the polio vaccine, sparking mass interest in the cells. As demand grew, scientists cloned the cells in 1955. Since that time, over 10,000 patents involving HeLa cells have been registered. Researchers have used the cells to study disease and to test human sensitivity to new products and substances. More recently, the cells enabled the development of COVID-19 vaccines.”

It took nearly two decades for the Lacks family to learn about their relation to the immortal HeLa cells. During that time, the cells’ origin was mistakenly attributed in the media to fictitious names such as “Helen Lane” or “Helen Larson.”

In February 2010, Johns Hopkins addressed ethical concerns about the acquisition of the initial HeLa cells in a statement:

“It’s important to note that at the time the cells were taken from Mrs. Lacks’ tissue, the practice of obtaining informed consent from cell or tissue donors was essentially unknown among academic medical centers. Sixty years ago, there was no established practice of seeking permission to take tissue for scientific research purposes.”

But that’s not quite the full story. Skloot’s research in The Immortal Life of Henrietta Lacks revealed that additional cell samples were taken from Lacks beyond the initial two.

Lacks’ cells were special, but by the time Gey hoped to collect more samples, she had died. “Though no law or code of ethics required doctors to ask permission before taking tissue from a living patient,” Skloot wrote, “the law made it very clear that performing an autopsy or removing tissue from the dead without permission was illegal.”

After Lacks’ death, doctors sought consent from her husband, Day, to perform an autopsy, but he initially refused. When they approached Day a second time, suggesting that the autopsy could yield test results that might benefit their children in the future, Day relented and gave his permission. Unfortunately, the promised test results were never provided to the Lacks family.

Johns Hopkins maintains that the obfuscation wasn’t for financial gain. The university says, “Johns Hopkins has never sold or profited from the discovery or distribution of HeLa cells and does not own the rights to the HeLa cell line. Rather, Johns Hopkins offered HeLa cells freely and widely for scientific research.”

But other companies have financially benefited from the HeLa cells. Notably, Thermo Fisher Scientific reached a settlement with the Lacks family in 2023 over products related to the HeLa cell line, as reported by NPR . This settlement acknowledges the commercial use and financial gains derived from Lacks’ cells.

Dr. Gey’s actions, which were typical of an era when the potential benefits to many patients took precedence over the rights of individual medical research subjects, could have been driven by the belief that prioritizing consent might impede scientific progress. It wasn’t until 15 years after Lacks’ cells were harvested that a landmark research paper changed that belief.

The Evolution of Medical Ethics in America

Ethical standards in American medical science have dramatically evolved over the past century, notably in the attitude toward eugenics, which is the science of promoting desirable qualities in the human race, usually through some kind of controlled breeding.

“When most people think of eugenics, they think of the unspeakable acts of Adolf Hitler and Dr. Josef Mengele ,” Dr. Marilyn M. Singleton wrote in an article for the Journal of American Physicians and Surgeons . “ But history tells us that some of America’s best and brightest promoted eugenics as settled science and necessary for the preservation of society.” (For example, Harvard professor W.E.B. DuBois supported selective breeding within the Black community, birth control pioneer Margaret Sanger advocated for “negative eugenics,” and even the NAACP ran “Better Baby” contests to fund its anti-lynching efforts.)

After World War II, the revelation of Nazi medical crimes during the Doctors’ Trials at Nuremberg, including the experiments by Mengele, radically changed American views on eugenics and led to the Nuremberg Code, which prioritized voluntary consent in medical research. But the U.S. didn’t legally adopt the Nuremberg Code, nor immediately recognize the similarities between Nazi human experiments and its own practices, such as collecting Lacks’ cells without her consent.

In 1966, two decades after the start of the Doctors’ Trial, and 15 years after the death of Henrietta Lacks, Dr. Henry K. Beecher published a paper in The New England Journal of Medicine titled, “ Ethics and Clinical Research .” It’s also known within medical circles today colloquially as “ Beecher’s Bombshell .”

The paper criticized the use of unwitting patients in experiments that offered no benefit and often harmed them, detailing 22 shocking cases including soldiers given placebos for rheumatic fever based solely on their serial number, and patients being injected with live cancer cells without their informed consent.

The experiments chronicled in Beecher’s report rocked the medical world, since these were conducted not by German men on trial, but by respected institutions, prestigious scientists, and the U.S. military. Years later, the Office of Human Research Protections stated that this paper contributed to “the impetus for the first [National Institutes of Health] and [Food and Drug Administration] regulations.”

Beecher’s paper strongly advocated for informed consent, challenging the prevailing notion among some circles that ethical scrutiny could hinder scientific progress.

How We Remember Henrietta Lacks

The story of Henrietta Lacks is often framed by the medical breakthroughs that her immortal cells facilitated, with a focus on the collective benefit rather than the ethical missteps that scientists took, and her family’s ignorance and lack of compensation. But decades before Lacks’ story became widely known, Beecher already argued against this idea:

“An experiment is ethical or not at its inception," Beecher concludes, “it does not become ethical post hoc—ends do not justify means. There is no ethical distinction between ends and means.”

It’s impossible to say whether Henrietta Lacks would have consented to the use of her cells, especially with the knowledge of the remarkable medical achievements they’d unlock—achievements even the doctors who collected the cells couldn’t have predicted.

We know now that those HeLa cells changed medicine forever, and though some tried to obscure their origins, Henrietta Lacks is immortalized in medical history. But we also know now that, regardless of the laws at the time, it should have been Lacks’ choice whether she was immortalized at all. If only someone had thought to ask.

Michael Natale is the news editor for Best Products , covering a wide range of topics like gifting, lifestyle, pop culture, and more. He has covered pop culture and commerce professionally for over a decade. His past journalistic writing can be found on sites such as Yahoo! and Comic Book Resources , his podcast appearances can be found wherever you get your podcasts, and his fiction can’t be found anywhere, because it’s not particularly good. 

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A wild orangutan used a medicinal plant to treat a wound, scientists say

Scientists say they’ve observed an orangutan named Rakus appearing to treat a wound with medicine from a tropical plant. It’s the latest example of how some animals attempt to soothe their own ills with remedies found in the wild.

This combination of photos provided by the Suaq foundation shows a facial wound on Rakus, a wild male Sumatran orangutan in Gunung Leuser National Park, Indonesia, on June 23, 2022, two days before he applied chewed leaves from a medicinal plant, left, and on Aug. 25, 2022, after his facial wound was barely visible. (Armas, Safruddin/Suaq foundation via AP)

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This photo provided by the Suaq foundation shows Rakus, a wild male Sumatran orangutan in Gunung Leuser National Park, Indonesia, on Aug. 25, 2022, after his facial wound was barely visible. Two months earlier, researchers observed him apply chewed leaves from a plant, used throughout Southeast Asia to treat pain and inflammation and to kill bacteria, to the wound. (Safruddin/Suaq foundation via AP)

This photo provided by the Suaq foundation shows a facial wound on Rakus, a wild male Sumatran orangutan in Gunung Leuser National Park, Indonesia, on June 23, 2022, two days before he applied chewed leaves from a plant, used throughout Southeast Asia to treat pain and inflammation and to kill bacteria, to the wound. (Armas/Suaq foundation via AP)

WASHINGTON (AP) — An orangutan appeared to treat a wound with medicine from a tropical plant— the latest example of how some animals attempt to soothe their own ills with remedies found in the wild, scientists reported Thursday.

Scientists observed Rakus pluck and chew up leaves of a medicinal plant used by people throughout Southeast Asia to treat pain and inflammation. The adult male orangutan then used his fingers to apply the plant juices to an injury on the right cheek. Afterward, he pressed the chewed plant to cover the open wound like a makeshift bandage, according to a new study in Scientific Reports .

Previous research has documented several species of great apes foraging for medicines in forests to heal themselves, but scientists hadn’t yet seen an animal treat itself in this way.

“This is the first time that we have observed a wild animal applying a quite potent medicinal plant directly to a wound,” said co-author Isabelle Laumer, a biologist at the Max Planck Institute of Animal Behavior in Konstanz, Germany.

The orangutan’s intriguing behavior was recorded in 2022 by Ulil Azhari, a co-author and field researcher at the Suaq Project in Medan, Indonesia. Photographs show the animal’s wound closed within a month without any problems.

Scientists have been observing orangutans in Indonesia’s Gunung Leuser National Park since 1994, but they hadn’t previously seen this behavior.

“It’s a single observation,” said Emory University biologist Jacobus de Roode, who was not involved in the study. “But often we learn about new behaviors by starting with a single observation.”

“Very likely it’s self-medication,” said de Roode, adding that the orangutan applied the plant only to the wound and no other body part.

It’s possible Rakus learned the technique from other orangutans living outside the park and away from scientists’ daily scrutiny, said co-author Caroline Schuppli at Max Planck.

Rakus was born and lived as a juvenile outside the study area. Researchers believe the orangutan got hurt in a fight with another animal. It’s not known whether Rakus earlier treated other injuries.

Scientists have previously recorded other primates using plants to treat themselves.

Bornean orangutans rubbed themselves with juices from a medicinal plant, possibly to reduce body pains or chase away parasites.

Chimpanzees in multiple locations have been observed chewing on the shoots of bitter-tasting plants to soothe their stomachs. Gorillas, chimpanzees and bonobos swallow certain rough leaves whole to get rid of stomach parasites.

“If this behavior exists in some of our closest living relatives, what could that tell us about how medicine first evolved?” said Tara Stoinski, president and chief scientific officer of the nonprofit Dian Fossey Gorilla Fund, who had no role in the study.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.