how to formulate research questions in quantitative research

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How to Write Quantitative Research Questions: Types With Examples

For research to be effective, it becomes crucial to properly formulate the quantitative research questions in a correct way. Otherwise, you will not get the answers you were looking for.

Has it ever happened that you conducted a quantitative research study and found out the results you were expecting are quite different from the actual results?

This could happen due to many factors like the unpredictable nature of respondents, errors in calculation, research bias, etc. However, your quantitative research usually does not provide reliable results when questions are not written correctly.

We get it! Structuring the quantitative research questions can be a difficult task.

Hence, in this blog, we will share a few bits of advice on how to write good quantitative research questions. We will also look at different types of quantitative research questions along with their examples.

Let’s start:

How to Write Quantitative Research Questions?

When you want to obtain actionable insight into the trends and patterns of the research topic to make sense of it, quantitative research questions are your best bet.

Being objective in nature, these questions provide you with detailed information about the research topic and help in collecting quantifiable data that can be easily analyzed. This data can be generalized to the entire population and help make data-driven and sound decisions.

Respondents find it easier to answer quantitative survey questions than qualitative questions. At the same time, researchers can also analyze them quickly using various statistical models.

However, when it comes to writing the quantitative research questions, one can get a little overwhelmed as the entire study depends on the types of questions used.

There is no “one good way” to prepare these questions. However, to design well-structured quantitative research questions, you can follow the 4-steps approach given below:

1. Select the Type of Quantitative Question

The first step is to determine which type of quantitative question you want to add to your study. There are three types of quantitative questions:

• Descriptive
• Comparative 
• Relationship-based

This will help you choose the correct words and phrases while constructing the question. At the same time, it will also assist readers in understanding the question correctly.

2. Identify the Type of Variable

The second step involves identifying the type of variable you are trying to measure, manipulate, or control. Basically, there are two types of variables:

• Independent variable (a variable that is being manipulated)
• Dependent variable (outcome variable)

If you plan to use descriptive research questions, you have to deal with a number of dependent variables. However, where you plan to create comparative or relationship research questions, you will deal with both dependent and independent variables.

3. Select the Suitable Structure

The next step is determining the structure of the research question. It involves:

• Identifying the components of the question. It involves the type of dependent or independent variable and a group of interest (the group from which the researcher tries to conclude the population).
• The number of different components used. Like, as to how many variables and groups are being examined.
• Order in which these are presented. For example, the independent variable before the dependent variable or vice versa.

4. Draft the Complete Research Question

The last step involves identifying the problem or issue that you are trying to address in the form of complete quantitative survey questions . Also, make sure to build an exhaustive list of response options to make sure your respondents select the correct response. If you miss adding important answer options, then the ones chosen by respondents may not be entirely true.

Types of Quantitative Research Questions With Examples

Quantitative research questions are generally used to answer the “who” and “what” of the research topic. For quantitative research to be effective, it is crucial that the respondents are able to answer your questions concisely and precisely. With that in mind, let’s look in greater detail at the three types of formats you can use when preparing quantitative market research questions.

1. Descriptive

Descriptive research questions are used to collect participants’ opinions about the variable that you want to quantify. It is the most effortless way to measure the particular variable (single or multiple variables) you are interested in on a large scale. Usually, descriptive research questions begin with “ how much,” “how often,” “what percentage,” “what proportion,” etc.

Examples of descriptive research questions include:

2. Comparative

Comparative research questions help you identify the difference between two or more groups based on one or more variables. In general, a comparative research question is used to quantify one variable; however, you can use two or more variables depending on your market research objectives.

Comparative research questions examples include:

3. Relationship-based

Relationship research questions are used to identify trends, causal relationships, or associations between two or more variables. It is not vital to distinguish between causal relationships, trends, or associations while using these types of questions. These questions begin with “What is the relationship” between independent and dependent variables, amongst or between two or more groups.

Relationship-based quantitative questions examples include:

Ready to Write Your Quantitative Research Questions?

So, there you have it. It was all about quantitative research question types and their examples. By now, you must have figured out a way to write quantitative research questions for your survey to collect actionable customer feedback.

Now, the only thing you need is a good survey maker tool , like ProProfs Survey Maker , that will glide your process of designing and conducting your surveys . You also get access to various survey question types, both qualitative and quantitative, that you can add to any kind of survey along with professionally-designed survey templates .

About the author

Emma David is a seasoned market research professional with 8+ years of experience. Having kick-started her journey in research, she has developed rich expertise in employee engagement, survey creation and administration, and data management. Emma believes in the power of data to shape business performance positively. She continues to help brands and businesses make strategic decisions and improve their market standing through her understanding of research methodologies.

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How to structure quantitative research questions

There is no "one best way" to structure a quantitative research question. However, to create a well-structured quantitative research question, we recommend an approach that is based on four steps : (1) Choosing the type of quantitative research question you are trying to create (i.e., descriptive, comparative or relationship-based); (2) Identifying the different types of variables you are trying to measure, manipulate and/or control, as well as any groups you may be interested in; (3) Selecting the appropriate structure for the chosen type of quantitative research question, based on the variables and/or groups involved; and (4) Writing out the problem or issues you are trying to address in the form of a complete research question. In this article, we discuss each of these four steps , as well as providing examples for the three types of quantitative research question you may want to create: descriptive , comparative and relationship-based research questions .

• STEP ONE: Choose the type of quantitative research question (i.e., descriptive, comparative or relationship) you are trying to create
• STEP TWO: Identify the different types of variable you are trying to measure, manipulate and/or control, as well as any groups you may be interested in
• STEP THREE: Select the appropriate structure for the chosen type of quantitative research question, based on the variables and/or groups involved
• STEP FOUR: Write out the problem or issues you are trying to address in the form of a complete research question

STEP ONE Choose the type of quantitative research question (i.e., descriptive, comparative or relationship) you are trying to create

The type of quantitative research question that you use in your dissertation (i.e., descriptive , comparative and/or relationship-based ) needs to be reflected in the way that you write out the research question; that is, the word choice and phrasing that you use when constructing a research question tells the reader whether it is a descriptive, comparative or relationship-based research question. Therefore, in order to know how to structure your quantitative research question, you need to start by selecting the type of quantitative research question you are trying to create: descriptive, comparative and/or relationship-based.

STEP TWO Identify the different types of variable you are trying to measure, manipulate and/or control, as well as any groups you may be interested in

Whether you are trying to create a descriptive, comparative or relationship-based research question, you will need to identify the different types of variable that you are trying to measure , manipulate and/or control . If you are unfamiliar with the different types of variable that may be part of your study, the article, Types of variable , should get you up to speed. It explains the two main types of variables: categorical variables (i.e., nominal , dichotomous and ordinal variables) and continuous variables (i.e., interval and ratio variables). It also explains the difference between independent and dependent variables , which you need to understand to create quantitative research questions.

To provide a brief explanation; a variable is not only something that you measure , but also something that you can manipulate and control for. In most undergraduate and master's level dissertations, you are only likely to measure and manipulate variables. You are unlikely to carry out research that requires you to control for variables, although some supervisors will expect this additional level of complexity. If you plan to only create descriptive research questions , you may simply have a number of dependent variables that you need to measure. However, where you plan to create comparative and/or relationship-based research questions , you will deal with both dependent and independent variables . An independent variable (sometimes called an experimental or predictor variable ) is a variable that is being manipulated in an experiment in order to observe the effect this has on a dependent variable (sometimes called an outcome variable ). For example, if we were interested in investigating the relationship between gender and attitudes towards music piracy amongst adolescents , the independent variable would be gender and the dependent variable attitudes towards music piracy . This example also highlights the need to identify the group(s) you are interested in. In this example, the group of interest are adolescents .

Once you identifying the different types of variable you are trying to measure, manipulate and/or control, as well as any groups you may be interested in, it is possible to start thinking about the way that the three types of quantitative research question can be structured . This is discussed next.

STEP THREE Select the appropriate structure for the chosen type of quantitative research question, based on the variables and/or groups involved

The structure of the three types of quantitative research question differs, reflecting the goals of the question, the types of variables, and the number of variables and groups involved. By structure , we mean the components of a research question (i.e., the types of variables, groups of interest), the number of these different components (i.e., how many variables and groups are being investigated), and the order that these should be presented (e.g., independent variables before dependent variables). The appropriate structure for each of these quantitative research questions is set out below:

Structure of descriptive research questions

• Structure of comparative research questions
• Structure of relationship-based research questions

There are six steps required to construct a descriptive research question: (1) choose your starting phrase; (2) identify and name the dependent variable; (3) identify the group(s) you are interested in; (4) decide whether dependent variable or group(s) should be included first, last or in two parts; (5) include any words that provide greater context to your question; and (6) write out the descriptive research question. Each of these steps is discussed in turn:

Choose your starting phrase

Identify and name the dependent variable

Identify the group(s) you are interested in

Decide whether the dependent variable or group(s) should be included first, last or in two parts

Include any words that provide greater context to your question

Write out the descriptive research question

FIRST Choose your starting phrase

You can start descriptive research questions with any of the following phrases:

How many? How often? How frequently? How much? What percentage? What proportion? To what extent? What is? What are?

Some of these starting phrases are highlighted in blue text in the examples below:

How many calories do American men and women consume per day?

How often do British university students use Facebook each week?

What are the most important factors that influence the career choices of Australian university students?

What proportion of British male and female university students use the top 5 social networks?

What percentage of American men and women exceed their daily calorific allowance?

SECOND Identify and name the dependent variable

All descriptive research questions have a dependent variable. You need to identify what this is. However, how the dependent variable is written out in a research question and what you call it are often two different things. In the examples below, we have illustrated the name of the dependent variable and highlighted how it would be written out in the blue text .

The first two examples highlight that while the name of the dependent variable is the same, namely daily calorific intake , the way that this dependent variable is written out differs in each case.

THIRD Identify the group(s) you are interested in

All descriptive research questions have at least one group , but can have multiple groups . You need to identify this group(s). In the examples below, we have identified the group(s) in the green text .

What are the most important factors that influence the career choices of Australian university students ?

The examples illustrate the difference between the use of a single group (e.g., British university students ) and multiple groups (e.g., American men and women ).

FOURTH Decide whether the dependent variable or group(s) should be included first, last or in two parts

Sometimes it makes more sense for the dependent variable to appear before the group(s) you are interested in, but sometimes it is the opposite way around. The following examples illustrate this, with the group(s) in green text and the dependent variable in blue text :

Group 1st; dependent variable 2nd:

How often do British university students use Facebook each week ?

Dependent variable 1st; group 2nd:

Sometimes, the dependent variable needs to be broken into two parts around the group(s) you are interested in so that the research question flows. Again, the group(s) are in green text and the dependent variable is in blue text :

How many calories do American men and women consume per day ?

Of course, you could choose to restructure the question above so that you do not have to split the dependent variable into two parts. For example:

How many calories are consumed per day by American men and women ?

When deciding whether the dependent variable or group(s) should be included first or last, and whether the dependent variable should be broken into two parts, the main thing you need to think about is flow : Does the question flow? Is it easy to read?

FIFTH Include any words that provide greater context to your question

Sometimes the name of the dependent variable provides all the explanation we need to know what we are trying to measure. Take the following examples:

In the first example, the dependent variable is daily calorific intake (i.e., calories consumed per day). Clearly, this descriptive research question is asking us to measure the number of calories American men and women consume per day. In the second example, the dependent variable is Facebook usage per week. Again, the name of this dependent variable makes it easy for us to understand that we are trying to measure the often (i.e., how frequently; e.g., 16 times per week) British university students use Facebook.

However, sometimes a descriptive research question is not simply interested in measuring the dependent variable in its entirety, but a particular component of the dependent variable. Take the following examples in red text :

In the first example, the research question is not simply interested in the daily calorific intake of American men and women, but what percentage of these American men and women exceeded their daily calorific allowance. So the dependent variable is still daily calorific intake, but the research question aims to understand a particular component of that dependent variable (i.e., the percentage of American men and women exceeding the recommend daily calorific allowance). In the second example, the research question is not only interested in what the factors influencing career choices are, but which of these factors are the most important.

Therefore, when you think about constructing your descriptive research question, make sure you have included any words that provide greater context to your question.

SIXTH Write out the descriptive research question

Once you have these details ? (1) the starting phrase, (2) the name of the dependent variable, (3) the name of the group(s) you are interested in, and (4) any potential joining words ? you can write out the descriptive research question in full. The example descriptive research questions discussed above are written out in full below:

In the section that follows, the structure of comparative research questions is discussed.

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How to Write a Research Question: Types and Examples 

The first step in any research project is framing the research question. It can be considered the core of any systematic investigation as the research outcomes are tied to asking the right questions. Thus, this primary interrogation point sets the pace for your research as it helps collect relevant and insightful information that ultimately influences your work.   

Typically, the research question guides the stages of inquiry, analysis, and reporting. Depending on the use of quantifiable or quantitative data, research questions are broadly categorized into quantitative or qualitative research questions. Both types of research questions can be used independently or together, considering the overall focus and objectives of your research.  

What is a research question?

A research question is a clear, focused, concise, and arguable question on which your research and writing are centered. 1 It states various aspects of the study, including the population and variables to be studied and the problem the study addresses. These questions also set the boundaries of the study, ensuring cohesion. 

Designing the research question is a dynamic process where the researcher can change or refine the research question as they review related literature and develop a framework for the study. Depending on the scale of your research, the study can include single or multiple research questions. 

A good research question has the following features: 

• It is relevant to the chosen field of study. 
• The question posed is arguable and open for debate, requiring synthesizing and analysis of ideas. 
• It is focused and concisely framed. 
• A feasible solution is possible within the given practical constraint and timeframe. 

A poorly formulated research question poses several risks. 1   

• Researchers can adopt an erroneous design. 
• It can create confusion and hinder the thought process, including developing a clear protocol.  
• It can jeopardize publication efforts.  
• It causes difficulty in determining the relevance of the study findings.  
• It causes difficulty in whether the study fulfils the inclusion criteria for systematic review and meta-analysis. This creates challenges in determining whether additional studies or data collection is needed to answer the question.  
• Readers may fail to understand the objective of the study. This reduces the likelihood of the study being cited by others. 

Now that you know “What is a research question?”, let’s look at the different types of research questions. 

Types of research questions

Depending on the type of research to be done, research questions can be classified broadly into quantitative, qualitative, or mixed-methods studies. Knowing the type of research helps determine the best type of research question that reflects the direction and epistemological underpinnings of your research. 

The structure and wording of quantitative 2 and qualitative research 3 questions differ significantly. The quantitative study looks at causal relationships, whereas the qualitative study aims at exploring a phenomenon. 

• Quantitative research questions:  
• Seeks to investigate social, familial, or educational experiences or processes in a particular context and/or location.  
• Answers ‘how,’ ‘what,’ or ‘why’ questions. 
• Investigates connections, relations, or comparisons between independent and dependent variables. 

Quantitative research questions can be further categorized into descriptive, comparative, and relationship, as explained in the Table below. 

• Qualitative research questions  

Qualitative research questions are adaptable, non-directional, and more flexible. It concerns broad areas of research or more specific areas of study to discover, explain, or explore a phenomenon. These are further classified as follows: 

• Mixed-methods studies  

Mixed-methods studies use both quantitative and qualitative research questions to answer your research question. Mixed methods provide a complete picture than standalone quantitative or qualitative research, as it integrates the benefits of both methods. Mixed methods research is often used in multidisciplinary settings and complex situational or societal research, especially in the behavioral, health, and social science fields. 

What makes a good research question

A good research question should be clear and focused to guide your research. It should synthesize multiple sources to present your unique argument, and should ideally be something that you are interested in. But avoid questions that can be answered in a few factual statements. The following are the main attributes of a good research question. 

• Specific: The research question should not be a fishing expedition performed in the hopes that some new information will be found that will benefit the researcher. The central research question should work with your research problem to keep your work focused. If using multiple questions, they should all tie back to the central aim. 
• Measurable: The research question must be answerable using quantitative and/or qualitative data or from scholarly sources to develop your research question. If such data is impossible to access, it is better to rethink your question. 
• Attainable: Ensure you have enough time and resources to do all research required to answer your question. If it seems you will not be able to gain access to the data you need, consider narrowing down your question to be more specific. 
• You have the expertise 
• You have the equipment and resources 
• Realistic: Developing your research question should be based on initial reading about your topic. It should focus on addressing a problem or gap in the existing knowledge in your field or discipline. 
• Based on some sort of rational physics 
• Can be done in a reasonable time frame 
• Timely: The research question should contribute to an existing and current debate in your field or in society at large. It should produce knowledge that future researchers or practitioners can later build on. 
• Novel 
• Based on current technologies. 
• Important to answer current problems or concerns. 
• Lead to new directions. 
• Important: Your question should have some aspect of originality. Incremental research is as important as exploring disruptive technologies. For example, you can focus on a specific location or explore a new angle. 
• Meaningful whether the answer is “Yes” or “No.” Closed-ended, yes/no questions are too simple to work as good research questions. Such questions do not provide enough scope for robust investigation and discussion. A good research question requires original data, synthesis of multiple sources, and original interpretation and argumentation before providing an answer. 

Steps for developing a good research question

The importance of research questions cannot be understated. When drafting a research question, use the following frameworks to guide the components of your question to ease the process. 4  

• Determine the requirements: Before constructing a good research question, set your research requirements. What is the purpose? Is it descriptive, comparative, or explorative research? Determining the research aim will help you choose the most appropriate topic and word your question appropriately. 
• Select a broad research topic: Identify a broader subject area of interest that requires investigation. Techniques such as brainstorming or concept mapping can help identify relevant connections and themes within a broad research topic. For example, how to learn and help students learn. 
• Perform preliminary investigation: Preliminary research is needed to obtain up-to-date and relevant knowledge on your topic. It also helps identify issues currently being discussed from which information gaps can be identified. 
• Narrow your focus: Narrow the scope and focus of your research to a specific niche. This involves focusing on gaps in existing knowledge or recent literature or extending or complementing the findings of existing literature. Another approach involves constructing strong research questions that challenge your views or knowledge of the area of study (Example: Is learning consistent with the existing learning theory and research). 
• Identify the research problem: Once the research question has been framed, one should evaluate it. This is to realize the importance of the research questions and if there is a need for more revising (Example: How do your beliefs on learning theory and research impact your instructional practices). 

How to write a research question

Those struggling to understand how to write a research question, these simple steps can help you simplify the process of writing a research question. 

Sample Research Questions

The following are some bad and good research question examples 

• Example 1 
• Example 2 

References:  

• Thabane, L., Thomas, T., Ye, C., & Paul, J. (2009). Posing the research question: not so simple.  Canadian Journal of Anesthesia/Journal canadien d’anesthésie ,  56 (1), 71-79. 
• Rutberg, S., & Bouikidis, C. D. (2018). Focusing on the fundamentals: A simplistic differentiation between qualitative and quantitative research.  Nephrology Nursing Journal ,  45 (2), 209-213. 
• Kyngäs, H. (2020). Qualitative research and content analysis.  The application of content analysis in nursing science research , 3-11. 
• Mattick, K., Johnston, J., & de la Croix, A. (2018). How to… write a good research question.  The clinical teacher ,  15 (2), 104-108. 
• Fandino, W. (2019). Formulating a good research question: Pearls and pitfalls.  Indian Journal of Anaesthesia ,  63 (8), 611. 
• Richardson, W. S., Wilson, M. C., Nishikawa, J., & Hayward, R. S. (1995). The well-built clinical question: a key to evidence-based decisions.  ACP journal club ,  123 (3), A12-A13 

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• 8 Most Effective Ways to Increase Motivation for Thesis Writing 
• 6 Tips for Post-Doc Researchers to Take Their Career to the Next Level

Transitive and Intransitive Verbs in the World of Research

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Research Questions & Hypotheses

Generally, in quantitative studies, reviewers expect hypotheses rather than research questions. However, both research questions and hypotheses serve different purposes and can be beneficial when used together.

Research Questions

Clarify the research’s aim (farrugia et al., 2010).

• Research often begins with an interest in a topic, but a deep understanding of the subject is crucial to formulate an appropriate research question.
• Descriptive: “What factors most influence the academic achievement of senior high school students?”
• Comparative: “What is the performance difference between teaching methods A and B?”
• Relationship-based: “What is the relationship between self-efficacy and academic achievement?”
• Increasing knowledge about a subject can be achieved through systematic literature reviews, in-depth interviews with patients (and proxies), focus groups, and consultations with field experts.
• Some funding bodies, like the Canadian Institute for Health Research, recommend conducting a systematic review or a pilot study before seeking grants for full trials.
• The presence of multiple research questions in a study can complicate the design, statistical analysis, and feasibility.
• It’s advisable to focus on a single primary research question for the study.
• The primary question, clearly stated at the end of a grant proposal’s introduction, usually specifies the study population, intervention, and other relevant factors.
• The FINER criteria underscore aspects that can enhance the chances of a successful research project, including specifying the population of interest, aligning with scientific and public interest, clinical relevance, and contribution to the field, while complying with ethical and national research standards.
• The P ICOT approach is crucial in developing the study’s framework and protocol, influencing inclusion and exclusion criteria and identifying patient groups for inclusion.
• Defining the specific population, intervention, comparator, and outcome helps in selecting the right outcome measurement tool.
• The more precise the population definition and stricter the inclusion and exclusion criteria, the more significant the impact on the interpretation, applicability, and generalizability of the research findings.
• A restricted study population enhances internal validity but may limit the study’s external validity and generalizability to clinical practice.
• A broadly defined study population may better reflect clinical practice but could increase bias and reduce internal validity.
• An inadequately formulated research question can negatively impact study design, potentially leading to ineffective outcomes and affecting publication prospects.

Checklist: Good research questions for social science projects (Panke, 2018)

Research Hypotheses

Present the researcher’s predictions based on specific statements.

• These statements define the research problem or issue and indicate the direction of the researcher’s predictions.
• Formulating the research question and hypothesis from existing data (e.g., a database) can lead to multiple statistical comparisons and potentially spurious findings due to chance.
• The research or clinical hypothesis, derived from the research question, shapes the study’s key elements: sampling strategy, intervention, comparison, and outcome variables.
• Hypotheses can express a single outcome or multiple outcomes.
• After statistical testing, the null hypothesis is either rejected or not rejected based on whether the study’s findings are statistically significant.
• Hypothesis testing helps determine if observed findings are due to true differences and not chance.
• Hypotheses can be 1-sided (specific direction of difference) or 2-sided (presence of a difference without specifying direction).
• 2-sided hypotheses are generally preferred unless there’s a strong justification for a 1-sided hypothesis.
• A solid research hypothesis, informed by a good research question, influences the research design and paves the way for defining clear research objectives.

Types of Research Hypothesis

• In a Y-centered research design, the focus is on the dependent variable (DV) which is specified in the research question. Theories are then used to identify independent variables (IV) and explain their causal relationship with the DV.
• Example: “An increase in teacher-led instructional time (IV) is likely to improve student reading comprehension scores (DV), because extensive guided practice under expert supervision enhances learning retention and skill mastery.”
• Hypothesis Explanation: The dependent variable (student reading comprehension scores) is the focus, and the hypothesis explores how changes in the independent variable (teacher-led instructional time) affect it.
• In X-centered research designs, the independent variable is specified in the research question. Theories are used to determine potential dependent variables and the causal mechanisms at play.
• Example: “Implementing technology-based learning tools (IV) is likely to enhance student engagement in the classroom (DV), because interactive and multimedia content increases student interest and participation.”
• Hypothesis Explanation: The independent variable (technology-based learning tools) is the focus, with the hypothesis exploring its impact on a potential dependent variable (student engagement).
• Probabilistic hypotheses suggest that changes in the independent variable are likely to lead to changes in the dependent variable in a predictable manner, but not with absolute certainty.
• Example: “The more teachers engage in professional development programs (IV), the more their teaching effectiveness (DV) is likely to improve, because continuous training updates pedagogical skills and knowledge.”
• Hypothesis Explanation: This hypothesis implies a probable relationship between the extent of professional development (IV) and teaching effectiveness (DV).
• Deterministic hypotheses state that a specific change in the independent variable will lead to a specific change in the dependent variable, implying a more direct and certain relationship.
• Example: “If the school curriculum changes from traditional lecture-based methods to project-based learning (IV), then student collaboration skills (DV) are expected to improve because project-based learning inherently requires teamwork and peer interaction.”
• Hypothesis Explanation: This hypothesis presumes a direct and definite outcome (improvement in collaboration skills) resulting from a specific change in the teaching method.
• Example : “Students who identify as visual learners will score higher on tests that are presented in a visually rich format compared to tests presented in a text-only format.”
• Explanation : This hypothesis aims to describe the potential difference in test scores between visual learners taking visually rich tests and text-only tests, without implying a direct cause-and-effect relationship.
• Example : “Teaching method A will improve student performance more than method B.”
• Explanation : This hypothesis compares the effectiveness of two different teaching methods, suggesting that one will lead to better student performance than the other. It implies a direct comparison but does not necessarily establish a causal mechanism.
• Example : “Students with higher self-efficacy will show higher levels of academic achievement.”
• Explanation : This hypothesis predicts a relationship between the variable of self-efficacy and academic achievement. Unlike a causal hypothesis, it does not necessarily suggest that one variable causes changes in the other, but rather that they are related in some way.

Tips for developing research questions and hypotheses for research studies

• Perform a systematic literature review (if one has not been done) to increase knowledge and familiarity with the topic and to assist with research development.
• Learn about current trends and technological advances on the topic.
• Seek careful input from experts, mentors, colleagues, and collaborators to refine your research question as this will aid in developing the research question and guide the research study.
• Use the FINER criteria in the development of the research question.
• Ensure that the research question follows PICOT format.
• Develop a research hypothesis from the research question.
• Ensure that the research question and objectives are answerable, feasible, and clinically relevant.

If your research hypotheses are derived from your research questions, particularly when multiple hypotheses address a single question, it’s recommended to use both research questions and hypotheses. However, if this isn’t the case, using hypotheses over research questions is advised. It’s important to note these are general guidelines, not strict rules. If you opt not to use hypotheses, consult with your supervisor for the best approach.

Farrugia, P., Petrisor, B. A., Farrokhyar, F., & Bhandari, M. (2010). Practical tips for surgical research: Research questions, hypotheses and objectives.  Canadian journal of surgery. Journal canadien de chirurgie ,  53 (4), 278–281.

Hulley, S. B., Cummings, S. R., Browner, W. S., Grady, D., & Newman, T. B. (2007). Designing clinical research. Philadelphia.

Panke, D. (2018). Research design & method selection: Making good choices in the social sciences.  Research Design & Method Selection , 1-368.

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Formulating your research question (rq).

In an effort to make our handouts more accessible, we have begun converting our PDF handouts to web pages. Download this page as a PDF: Formulating Your Research Question Return to Writing Studio Handouts

In a research paper, the emphasis is on generating a unique question and then synthesizing diverse sources into a coherent essay that supports your argument about the topic. In other words, you integrate information from publications with your own thoughts in order to formulate an argument. Your topic is your starting place: from here, you will develop an engaging research question. Merely presenting a topic in the form of a question does not transform it into a good research question.

Research Topic Versus Research Question Examples

1. broad topic versus narrow question, 1a. broad topic.

“What forces affect race relations in America?”

1b. NARROWER QUESTION

“How do corporate hiring practices affect race relations in Nashville?”

The question “What is the percentage of racial minorities holding management positions in corporate offices in Nashville?” is much too specific and would yield, at best, a statistic that could become part of a larger argument.

2. Neutral Topic Versus Argumentative Question

2a. neutral topic.

“How does KFC market its low-fat food offerings?”

2b. Argumentative question

“Does KFC put more money into marketing its high-fat food offerings than its lower-fat ones?”

The latter question is somewhat better, since it may lead you to take a stance or formulate an argument about consumer awareness or benefit.

3. Objective Topic Versus Subjective Question

Objective subjects are factual and do not have sides to be argued. Subjective subjects are those about which you can take a side.

3a. Objective topic

“How much time do youth between the ages of 10 and 15 spend playing video games?”

3b. Subjective Question

“What are the effects of video-gaming on the attention spans of youth between the ages of 10 and 15?”

The first question is likely to lead to some data, though not necessarily to an argument or issue. The second question is somewhat better, since it might lead you to formulate an argument for or against time spent playing video games.

4. Open-Ended Topic Versus Direct Question

4a. open-ended topic.

“Does the author of this text use allusion?”

4b. Direct question (gives direction to research)

“Does the ironic use of allusion in this text reveal anything about the author’s unwillingness to divulge his political commitments?”

The second question gives focus by putting the use of allusion into the specific context of a question about the author’s political commitments and perhaps also about the circumstances under which the text was produced.

Research Question (RQ) Checklist

• Is my RQ something that I am curious about and that others might care about? Does it present an issue on which I can take a stand?
• Does my RQ put a new spin on an old issue, or does it try to solve a problem?
• Is my RQ too broad, too narrow, or OK?
• within the time frame of the assignment?
• given the resources available at my location?
• Is my RQ measurable? What type of information do I need? Can I find actual data to support or contradict a position?
• What sources will have the type of information that I need to answer my RQ (journals, books, internet resources, government documents, interviews with people)?

Final Thoughts

The answer to a good research question will often be the THESIS of your research paper! And the results of your research may not always be what you expected them to be. Not only is this ok, it can be an indication that you are doing careful work!

Adapted from an online tutorial at Empire State College: http://www.esc.edu/htmlpages/writerold/menus.htm#develop (broken link)

Last revised: November 2022 | Adapted for web delivery: November 2022

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Research Questions Tutorial

What is a Quantitative Research Question?

A research question is the driving question(s) behind your research. It should be about an issue that you are genuinely curious and/or passionate about. A good research question is:

Clear :  The purpose of the study should be clear to the reader, without additional explanation.

Focused :  The question is specific. Narrow enough in scope that it can be thoroughly explored within the page limits of the research paper. It brings the common thread that weaves throughout the paper.

Concise :  Clarity should be obtained in the fewest possible words. This is not the place to add unnecessary descriptors and fluff (i.e. “very”).

Complex :  A true research question is not a yes/no question. It brings together a collection of ideas obtained from extensive research, without losing focus or clarity.

Arguable :  It doesn’t provide a definitive answer. Rather, it presents a potential position that future studies could debate.

The format of a research question will depend on a number of factors, including the area of discipline, the proposed research design, and the anticipated analysis.

Unclear:   Does loneliness cause the jitters? Clear:   What is the relationship between feelings of loneliness, as measured by the Lonely Inventory, and uncontrollable shaking?

Unfocused:   What’s the best way to learn? Focused:   In what ways do different teaching styles affect recall and retention in middle schoolers?

Verbose :  Can reading different books of varying genres influence a person’s performance on a test that measures familiarity and knowledge of different words?

Concise:   How does exposure to words through reading novels influence a person’s language development?

Definitive:   What is my favorite color? Arguable:   What is the most popular color amongst teens in America?

Developing a Quantitative Research Question

Developing a research question, was this resource helpful.

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• Quantitative research questions: Types, tips & examples

Defne Çobanoğlu

Deciding on your next survey’s goal gives you a starting point as to what kind of questions you will use on your survey. And if you want to do concrete market research, give a data summary to your supervisors, or make informed decisions based on the data you collect, you should use quantitative survey questions.

In this article, we have gathered more than 100 survey question examples about gender, marketing, stress, psychology, academic performance, social media, and mental health to get you started. You can add these questions to your next research survey, or you can use them to get inspiration to write many more. Let us get started!

• What is a quantitative research question?

The quantitative research question is a type of question where the person asking the question wants to obtain a numeric answer that will provide them with a tangible answer. It involves collecting objective, measurable data about a particular subject or topic, often through surveys, experiments, or other structured methods.

The definition of a quantitative research question

The data collected is typically numerical in nature, such as ratings, counts, measurements, or percentages . So, an answer to this type of question can be confidentially used when creating a quantitative analysis.

Quantitative vs. qualitative research questions

The main difference between quantitative and qualitative questions is what you want to achieve from the question and methods of data collection. Qualitative research focuses on exploring and understanding complex phenomena, experiences, and perspectives . And qualitative research questions aim to gather detailed descriptions and subjective experiences to gain insights.

On the other hand, quantitative research aims to answer questions that involve measuring and quantifying variables, examining relationships, and making statistical deductions. It mainly relies on structured data collection methods, such as surveys, experiments, observations, and existing datasets, in order to collect numerical data .

• How to write a quantitative research question

If you want to obtain concrete data on a research topic, you should use quantitative research questions. They give you numerical answers such as ratings, measurements, counts, or percentages. That makes it easier to conclude a quantitative analysis. Therefore, use questions that will give you answers like; “three times a week”, “about 11”, “20% of the students”, etc. Here are some question starters to have in mind to give you quantitative research questions ideas:

• How frequently?
• What percentage?
• To what extent?
• What proportion?
• On a scale of…

Here are some simple examples:

• How often do you go to the gym in a week?
• How much do you spend on groceries?
• How many phone calls do you make a day?
• Types of quantitative questions

When you try to get numerical answers, the only option is not the multiple-choice one. You can use different types of quantitative research questions to make the form more interesting, visually appealing, and detailed if you use a smart survey creator, such as forms.app, you can make use of its multiple smart form fields to build your form. Let us see what are some good options to use on your next survey.

Star rating:

It is a good way to ask people their opinions, and the survey takers can rate criteria based on different categories. Each star represents an equivalent numeric value, and they typically range from 1 to 5. Even if they are clicking on stars, you get numeric data in the end.

A star rating question example

Opinion scale:

It is basically the same thing with the stars but instead, the survey takers rate criteria as numbers from 1-5 or 1-10. It is better to keep in mind the best way for this is using a 1-5 scale, with 5 being the best and 1 being the worst rating.

An opinion scale question example

Picture selection:

Having people choose their opinions in a picture selection form is a good way to go. It is a good option to use when you are creating a survey for market research and such.

A picture selection question example

Multiple-choice:

When you ask people a question such as; “what are the reasons that negatively affect your mental health?” it is better to let them choose multiple reasons rather than a single one. You would not want to limit the target audience by making them choose only one thing on the list.

A multiple-choice question example

Selection matrix:

In this type of question, you can make multiple sentences, categories, and statements, and survey takers can answer them accordingly. They allow you to get the answers as one question rather than setting up multiple questions.

A selection matrix example

• 100+ Quantitative research questions to ask in your research surveys

In your next survey, you can use any of the questions below, or you can create your own. If you use smart questions focused on a subject or aspect, it will make it easier for you to make an informed analysis at the end. Now, let us start with the first one:

Quantitative research questions about gender

A question example about quantitative research about gender

Quantitative research questions about gender aim to gather numerical data to quantify and analyze gender-related patterns, differences, and associations. They focus on exploring gender-related issues and investigating gender influences on several aspects of life.

1 - What is the difference in average earnings between male and female employees in a specific industry?

2 - How does gender affect academic achievement in STEM subjects among high school students?

3 - What is the percentage of women in leadership positions in Fortune 500 companies?

4 - What is the impact of gender on access to and utilization of health services?

5 - What is the percentage of female students speaking in a classroom as opposed to male students?

6 - How does gender influence consumer preferences and purchasing behavior in the fashion industry?

7 - What are the gender differences in response to specific marketing strategies for a particular product?

8 - What is the correlation between gender and mental health outcomes in a specific population?

9 - How does gender influence the perception of work-life balance among working professionals?

10 - How often do you feel discriminated against in a work environment because of your gender?

11 - What is the effect of gender on smoking at the ages 14-18?

Quantitative research questions about stress

A question example about quantitative research about stress

Research questions about stress aim to investigate different aspects of stress, its causes, and its consequences. Researchers can measure stress levels and examine the relationships between stress and other variables. Also, they can analyze patterns and trends associated with stress after collecting appropriate data.

12 - On a scale of 1 to 10, how often do you feel stressed?

13 - What is the prevalence of stress among college students?

14 - How does stress impact academic achievement among high school students?

15 - How does mindfulness meditation training impact stress levels in university students?

16 - What are the primary sources of work-related stress among employees?

17 - What is the relationship between stress levels and job performance among healthcare professionals?

18 - Who are the people in your life that cause you the most stress?

19 - In the last month, how often have you felt that you were unable to control important things in your life?

20 - How does workplace stress influence employee turnover rates in a specific organization?

21 - What is the correlation between stress levels and physical health in young people?

22 - What are the demographic factors (such as age, gender, or income) associated with higher levels of stress?

23 - What is the impact of stress on sleep quality and duration among adults?

24 - What are the stress levels experienced by parents of children with special needs compared to parents of typically developing children?

25 - What is the effectiveness of stress management interventions in reducing stress levels among individuals with chronic illnesses?

26 - What is the impact of daily meditation helping stress levels?

27 - What are the factors contributing to job-related stress among healthcare professionals in a specific specialty?

Quantitative research questions in Psychology

A question example about quantitative research in psychology

Quantitative research questions in psychology cover a range of psychological topics, including mental health, personality, behavior, and social dynamics. The aim of these questions is to collect quantitative data to examine relationships, assess the effectiveness of interventions, and identify factors associated with psychological events.

28 - What is the relationship between self-esteem and academic performance in high school students?

29 - How does exposure to violent media affect aggressive behavior in children?

30 - What is the prevalence of depression among college students?

31 - How is parental attachment style associated with the development of anxiety disorders in children?

32 - How many times a month should one use professional therapy?

33 - What are the factors influencing job satisfaction among employees in a specific industry?

34 - What are the predictors of job performance among healthcare professionals?

35 - Generally, at what age do children start getting psychological help?

36 - What is the effect of cognitive-behavioral therapy on reducing symptoms of post-traumatic stress disorder?

37 - How does the classroom environment affect academic motivation and achievement in elementary school students?

38 - What is the effectiveness of a cognitive training program in improving memory function in older adults?

39 - How do exercise frequency and intensity impact symptoms of anxiety and depression in individuals with diagnosed mental health conditions?

40 - What is the correlation between sleep duration and academic performance in college students?

41 - How does parental divorce during childhood impact the development of attachment styles in adulthood?

42 - What is the relationship between self-esteem and job satisfaction among working professionals?

43 - What are the predictors of eating disorder symptoms in adolescent females?

44 - At what age the teenage girls prone to depression?

45 - What is the correlation between young adults and suicide rates?

46 - What is the effect of a specific cognitive training program on improving cognitive functioning in elders?

47 - How does the presence of social support networks impact resilience levels in individuals who have experienced traumatic events?

48 - What are the effects of a specific therapeutic intervention on reducing symptoms of anxiety in individuals with a generalized anxiety disorder?

49 - What is the correlation between social media use and symptoms of depression in young adults?

50 - How does mindfulness meditation training influence stress levels in individuals with high-stress occupations?

51 - How does exposure to violent video games affect aggressive behavior in adolescents?

Quantitative research questions about mental health

A question example about quantitative research about mental health

Quantitative research questions about mental health focus on various aspects of mental health, including the prevalence of disorders, risk factors, treatment interventions, and the impact of lifestyle factors. 

52 - How does the frequency of social media use relate to levels of depressive symptoms in adolescents?

53 - What is the correlation between sleep quality and mental health outcomes in adults with diagnosed mental health conditions?

54 - What is the percentage of people diagnosed with anxiety disorder that has a college education?

55 - What kind of activities helps with your mental health?

56 - How many times a week do you spare time for your mental well-being?

57 - What is the effect of a specific psychotherapy intervention on reducing symptoms of depression?

58 - What are the factors determining treatment adherence in patients with schizophrenia?

59 - How do exercise frequency and intensity relate to anxiety levels?

60 - What is the relationship between social support and endurance in individuals with a history of trauma?

61 - How does stigma surrounding mental illness influence help-seeking behavior among college students?

62 - What is the prevalence of anxiety disorders among college students?

Quantitative research questions about social media

A question example about quantitative research about social media

Quantitative research questions about social media try to explore various aspects of social media, including its impact on psychological well-being, behavior, relationships, and society. They aim to collect quantitative data to analyze relations, examine effects, and measure the influence of social media.

63 - How many times a day do you check your social media accounts?

64 - How much time do you spend on social media every day?

65 - How many social media accounts do you own?

66 - What is the correlation between social media engagement and academic performance in high school students?

67 - What are the most used social media accounts among teenagers?

68 - What is the psychological effect of social media accounts on young people?

69 - What is the relationship between social media use and self-esteem among adolescents?

70 - How does the frequency of social media use relate to levels of loneliness in young adults?

71 - How does exposure to idealized body images on social media impact body dissatisfaction in women?

72 - What are the predictors of problematic social media use among college students?

73 - How does social media use influence political attitudes and behaviors among young adults?

74 - What is the effect of social media advertising on consumer purchasing behavior and brand loyalty?

75 - What is the association between cyberbullying on social media and mental health outcomes among teenagers?

76 - How does social media use affect sleep quality and duration in adults?

77 - How does social media use impact interpersonal relationships and social support among individuals in long-distance relationships?

Quantitative research questions about academic performance

A question example about quantitative research about academic performance

Quantitative research questions about academic performance focus on academic performance, the predictors, and the elements affecting it negatively and positively. They aim to collect quantitative data to figure out the relation between academic performance and the environment of the students and make informed decisions.

78 - What is the correlation between student attendance rates and academic achievement in a specific grade level?

79 - How does parental involvement in education relate to students' academic performance?

80 - What is the impact of classroom size on student academic outcomes?

81 - What are the predictors of academic success among undergraduate students in a specific major?

82 - How many times were you absent during the last semester?

83 - What is the correlation between student engagement in extracurricular activities and their academic performance?

84 - What is the effect of peer tutoring programs on student grades and test scores?

85 - How do student motivation and self-efficacy influence academic achievement in a specific academic setting?

86 - What is the relationship between study habits and academic performance among high school students?

87 - How does the implementation of a specific teaching methodology or instructional approach impact student achievement in a particular subject?

Quantitative research questions about marketing

A question example about quantitative research about marketing

Quantitative research questions about marketing explore various aspects of marketing, including advertising effectiveness, consumer behavior, branding, pricing, and customer satisfaction. They involve collecting quantitative data to analyze relationships and assess the impact of marketing strategies. 

88 - What is the correlation between advertising expenditure and sales revenue for a specific product?

89 - As a consumer, how often do you make purchasing decisions based on marketing exposure?

90 - What are the top 5 brands that stand out to you because of ads of their quality?

91 - How does brand loyalty relate to customer satisfaction and repeat purchase behavior?

92 - What is the impact of pricing strategies on consumer purchase intentions and price sensitivity?

93 - When making a purchase, how important is the packaging of the product to you?

94 - What is the effectiveness of different marketing channels (e.g., social media, television, email marketing) in reaching and engaging the target audience?

95 - How does product packaging design influence consumer perception and purchase decisions?

96 - What are the key factors influencing customer loyalty in the retail industry?

97 - What is the relationship between online customer reviews and purchase decisions in e-commerce?

98 - How do brand reputation and perception affect consumer trust and willingness to recommend a product or service?

99 - What are the channels you visit to ensure the quality of the product you will purchase?

100 - How does the personalization of marketing messages impact customer engagement and response rates?

101 - What is the effect of promotional offers (e.g., discounts, coupons) on consumer purchase behavior?

102 - What is the effect of ad placement on popular social media accounts on teenagers?

• Tips for creating quantitative research questions

When you want to create your survey, you should be professional and collect the data systematically. That will help you have clear results. In order to achieve this: 

• Use clear and unambiguous language
• Avoid leading or biased questions 
• Use different question types 
• Keep the length of your survey at an appropriate level

After you create your survey in a systematic manner and use a competitive analysis framework to record your findings, you can achieve the concrete results you want. Also, always remember to obtain the necessary ethical approvals and informed consent required for your research study.

• How to create a quantitative research survey

When you are creating your next survey, you can go old-fashion and write everything down on a piece of paper and try to get people to fill them out. However, there is a much easier option thanks to online survey tools. And a great survey maker you can use is forms.app. It has over 1000 ready-to-use templates, and each of them is as useful. Now, let us go through the steps to creating a quantitative survey using forms.app:

1 - Go to forms.app and log in to your account (or create one for free).

2 - Go to the dropdown menu and click on the templates option .

3 - Choose one of the survey templates and click on the “use template” button and customize it as much as you want by adding question fields and changing the visuals as much as you want.

4 - Or, you can decide on starting from scratch and build everything from the start in a matter of minutes.

5 - Save your changes, and by clicking on the “eye” icon on the upper left side of the page, see the final result.

6 - Copy the unique link and share it with your audience. If you want, you can also embed the survey on the page of your choosing.

• Key points to take away

Creating a simple survey to collect numerical values to make informed and supported plans is very easy. It can be done with a simple and effective form creator, such as forms.app. It has many functional form fields and is also completely adjustable.

You can easily create your own research survey with the questions we have gathered for you. It should be mentioned that you should keep in mind to have a structured plan to go with. Because only then can you analyze your results effectively and repeat the research if it is needed.

Defne is a content writer at forms.app. She is also a translator specializing in literary translation. Defne loves reading, writing, and translating professionally and as a hobby. Her expertise lies in survey research, research methodologies, content writing, and translation.

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Module 2: Formulating a Research Question and Searching for Sources

Formulating a Research Question

As noted in Module 1: Types of Reviews , conducting a “pre-search” is a crucial first step in devising the research question. A well-formulated research question informs the research process. It can focus your information needs (i.e. identify inclusion and exclusion criteria), help to identify key search concepts, and guide you in the direction of relevant resources.

Types of Research Questions

There are two general types of research questions: quantitative and qualitative .

Quantitative Research Questions

Types of quantitative questions can be categorized as explanatory (i.e., relationship-based), descriptive, or comparative.

• Explanatory questions aim to discover cause-and-effect relationships by comparing two or more variables, individuals or groups based on differing outcomes.
• Descriptive questions will often quantify a single variable but may include multiple variables  within a question. They typically ask for measurements, and can begin with: “how much”, “what percentage”, “how frequently”, or “how many”.
• Comparative questions are designed to identify the “difference between” a dependent variable and two or more groups. These questions tend to begin with “what is the difference” or “what are the differences”.

Qualitative Research Questions

Qualitative questions aim to discover meaning or gain an understanding of a phenomenon. They ask questions that cannot be measured with specific numbers and statistics. Qualitative research questions often contain words like "lived experience" , “personal experience”, “understanding”, “meaning”, and “stories”.

A Comparison of Quantitative and Qualitative Questions

So how do quantitative and qualitative research questions differ when you are conducting a search? In Table 2.1 below, we provide some examples of research topics. Each topic can either be used for a quantitative or qualitative research question. For each question, the category of research question is clarified.

Key Takeaways

Regardless of the type of question being asked, a good research question cannot be answered with a simple yes or no (as demonstrated by the sample questions in Table 2.1).

Quantitative data can be counted, measured,  and  expressed using numbers.

Qualitative research relies on data obtained by the researcher from first-hand observation, interviews, questionnaires (on which participants write descriptively), focus groups, participant-observation, recordings made in natural settings, documents, and artifacts. The data are generally nonnumerical.

Personal knowledge about the world that has been gained through first-hand involvement in everyday events.

Advanced Research Skills: Conducting Literature and Systematic Reviews Copyright © 2021 by Kelly Dermody; Cecile Farnum; Daniel Jakubek; Jo-Anne Petropoulos; Jane Schmidt; and Reece Steinberg is licensed under a Creative Commons Attribution 4.0 International License , except where otherwise noted.

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Quantitative Research: Examples of Research Questions and Solutions

Are you ready to embark on a journey into the world of quantitative research? Whether you’re a seasoned researcher or just beginning your academic journey, understanding how to formulate effective research questions is essential for conducting meaningful studies. In this blog post, we’ll explore examples of quantitative research questions across various disciplines and discuss how StatsCamp.org courses can provide the tools and support you need to overcome any challenges you may encounter along the way.

Understanding Quantitative Research Questions

Quantitative research involves collecting and analyzing numerical data to answer research questions and test hypotheses. These questions typically seek to understand the relationships between variables, predict outcomes, or compare groups. Let’s explore some examples of quantitative research questions across different fields:

• What is the relationship between class size and student academic performance?
• Does the use of technology in the classroom improve learning outcomes?
• How does parental involvement affect student achievement?
• What is the effect of a new drug treatment on reducing blood pressure?
• Is there a correlation between physical activity levels and the risk of cardiovascular disease?
• How does socioeconomic status influence access to healthcare services?
• What factors influence consumer purchasing behavior?
• Is there a relationship between advertising expenditure and sales revenue?
• How do demographic variables affect brand loyalty?

Stats Camp: Your Solution to Mastering Quantitative Research Methodologies

At StatsCamp.org, we understand that navigating the complexities of quantitative research can be daunting. That’s why we offer a range of courses designed to equip you with the knowledge and skills you need to excel in your research endeavors. Whether you’re interested in learning about regression analysis, experimental design, or structural equation modeling, our experienced instructors are here to guide you every step of the way.

Bringing Your Own Data

One of the unique features of StatsCamp.org is the opportunity to bring your own data to the learning process. Our instructors provide personalized guidance and support to help you analyze your data effectively and overcome any roadblocks you may encounter. Whether you’re struggling with data cleaning, model specification, or interpretation of results, our team is here to help you succeed.

Courses Offered at StatsCamp.org

• Latent Profile Analysis Course : Learn how to identify subgroups, or profiles, within a heterogeneous population based on patterns of responses to multiple observed variables.
• Bayesian Statistics Course : A comprehensive introduction to Bayesian data analysis, a powerful statistical approach for inference and decision-making. Through a series of engaging lectures and hands-on exercises, participants will learn how to apply Bayesian methods to a wide range of research questions and data types.
• Structural Equation Modeling (SEM) Course : Dive into advanced statistical techniques for modeling complex relationships among variables.
• Multilevel Modeling Course : A in-depth exploration of this advanced statistical technique, designed to analyze data with nested structures or hierarchies. Whether you’re studying individuals within groups, schools within districts, or any other nested data structure, multilevel modeling provides the tools to account for the dependencies inherent in such data.

As you embark on your journey into quantitative research, remember that StatsCamp.org is here to support you every step of the way. Whether you’re formulating research questions, analyzing data, or interpreting results, our courses provide the knowledge and expertise you need to succeed. Join us today and unlock the power of quantitative research!

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Research Aims, Objectives & Questions

The “Golden Thread” Explained Simply (+ Examples)

By: David Phair (PhD) and Alexandra Shaeffer (PhD) | June 2022

The research aims , objectives and research questions (collectively called the “golden thread”) are arguably the most important thing you need to get right when you’re crafting a research proposal , dissertation or thesis . We receive questions almost every day about this “holy trinity” of research and there’s certainly a lot of confusion out there, so we’ve crafted this post to help you navigate your way through the fog.

Overview: The Golden Thread

• What is the golden thread
• What are research aims ( examples )
• What are research objectives ( examples )
• What are research questions ( examples )
• The importance of alignment in the golden thread

What is the “golden thread”?  

The golden thread simply refers to the collective research aims , research objectives , and research questions for any given project (i.e., a dissertation, thesis, or research paper ). These three elements are bundled together because it’s extremely important that they align with each other, and that the entire research project aligns with them.

Importantly, the golden thread needs to weave its way through the entirety of any research project , from start to end. In other words, it needs to be very clearly defined right at the beginning of the project (the topic ideation and proposal stage) and it needs to inform almost every decision throughout the rest of the project. For example, your research design and methodology will be heavily influenced by the golden thread (we’ll explain this in more detail later), as well as your literature review.

The research aims, objectives and research questions (the golden thread) define the focus and scope ( the delimitations ) of your research project. In other words, they help ringfence your dissertation or thesis to a relatively narrow domain, so that you can “go deep” and really dig into a specific problem or opportunity. They also help keep you on track , as they act as a litmus test for relevance. In other words, if you’re ever unsure whether to include something in your document, simply ask yourself the question, “does this contribute toward my research aims, objectives or questions?”. If it doesn’t, chances are you can drop it.

Alright, enough of the fluffy, conceptual stuff. Let’s get down to business and look at what exactly the research aims, objectives and questions are and outline a few examples to bring these concepts to life.

Research Aims: What are they?

Simply put, the research aim(s) is a statement that reflects the broad overarching goal (s) of the research project. Research aims are fairly high-level (low resolution) as they outline the general direction of the research and what it’s trying to achieve .

Research Aims: Examples  

True to the name, research aims usually start with the wording “this research aims to…”, “this research seeks to…”, and so on. For example:

“This research aims to explore employee experiences of digital transformation in retail HR.”   “This study sets out to assess the interaction between student support and self-care on well-being in engineering graduate students”  

As you can see, these research aims provide a high-level description of what the study is about and what it seeks to achieve. They’re not hyper-specific or action-oriented, but they’re clear about what the study’s focus is and what is being investigated.

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Research Objectives: What are they?

The research objectives take the research aims and make them more practical and actionable . In other words, the research objectives showcase the steps that the researcher will take to achieve the research aims.

The research objectives need to be far more specific (higher resolution) and actionable than the research aims. In fact, it’s always a good idea to craft your research objectives using the “SMART” criteria. In other words, they should be specific, measurable, achievable, relevant and time-bound”.

Research Objectives: Examples  

Let’s look at two examples of research objectives. We’ll stick with the topic and research aims we mentioned previously.  

For the digital transformation topic:

To observe the retail HR employees throughout the digital transformation. To assess employee perceptions of digital transformation in retail HR. To identify the barriers and facilitators of digital transformation in retail HR.

And for the student wellness topic:

To determine whether student self-care predicts the well-being score of engineering graduate students. To determine whether student support predicts the well-being score of engineering students. To assess the interaction between student self-care and student support when predicting well-being in engineering graduate students.

  As you can see, these research objectives clearly align with the previously mentioned research aims and effectively translate the low-resolution aims into (comparatively) higher-resolution objectives and action points . They give the research project a clear focus and present something that resembles a research-based “to-do” list.

Research Questions: What are they?

Finally, we arrive at the all-important research questions. The research questions are, as the name suggests, the key questions that your study will seek to answer . Simply put, they are the core purpose of your dissertation, thesis, or research project. You’ll present them at the beginning of your document (either in the introduction chapter or literature review chapter) and you’ll answer them at the end of your document (typically in the discussion and conclusion chapters).  

The research questions will be the driving force throughout the research process. For example, in the literature review chapter, you’ll assess the relevance of any given resource based on whether it helps you move towards answering your research questions. Similarly, your methodology and research design will be heavily influenced by the nature of your research questions. For instance, research questions that are exploratory in nature will usually make use of a qualitative approach, whereas questions that relate to measurement or relationship testing will make use of a quantitative approach.  

Let’s look at some examples of research questions to make this more tangible.

Research Questions: Examples  

Again, we’ll stick with the research aims and research objectives we mentioned previously.  

For the digital transformation topic (which would be qualitative in nature):

How do employees perceive digital transformation in retail HR? What are the barriers and facilitators of digital transformation in retail HR?  

And for the student wellness topic (which would be quantitative in nature):

Does student self-care predict the well-being scores of engineering graduate students? Does student support predict the well-being scores of engineering students? Do student self-care and student support interact when predicting well-being in engineering graduate students?  

You’ll probably notice that there’s quite a formulaic approach to this. In other words, the research questions are basically the research objectives “converted” into question format. While that is true most of the time, it’s not always the case. For example, the first research objective for the digital transformation topic was more or less a step on the path toward the other objectives, and as such, it didn’t warrant its own research question.  

So, don’t rush your research questions and sloppily reword your objectives as questions. Carefully think about what exactly you’re trying to achieve (i.e. your research aim) and the objectives you’ve set out, then craft a set of well-aligned research questions . Also, keep in mind that this can be a somewhat iterative process , where you go back and tweak research objectives and aims to ensure tight alignment throughout the golden thread.

The importance of strong alignment 

Alignment is the keyword here and we have to stress its importance . Simply put, you need to make sure that there is a very tight alignment between all three pieces of the golden thread. If your research aims and research questions don’t align, for example, your project will be pulling in different directions and will lack focus . This is a common problem students face and can cause many headaches (and tears), so be warned.

Take the time to carefully craft your research aims, objectives and research questions before you run off down the research path. Ideally, get your research supervisor/advisor to review and comment on your golden thread before you invest significant time into your project, and certainly before you start collecting data .  

Recap: The golden thread

In this post, we unpacked the golden thread of research, consisting of the research aims , research objectives and research questions . You can jump back to any section using the links below.

As always, feel free to leave a comment below – we always love to hear from you. Also, if you’re interested in 1-on-1 support, take a look at our private coaching service here.

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This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...

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39 Comments

Thank you very much for your great effort put. As an Undergraduate taking Demographic Research & Methodology, I’ve been trying so hard to understand clearly what is a Research Question, Research Aim and the Objectives in a research and the relationship between them etc. But as for now I’m thankful that you’ve solved my problem.

Well appreciated. This has helped me greatly in doing my dissertation.

An so delighted with this wonderful information thank you a lot.

so impressive i have benefited a lot looking forward to learn more on research.

I am very happy to have carefully gone through this well researched article.

Infact,I used to be phobia about anything research, because of my poor understanding of the concepts.

Now,I get to know that my research question is the same as my research objective(s) rephrased in question format.

I please I would need a follow up on the subject,as I intends to join the team of researchers. Thanks once again.

Thanks so much. This was really helpful.

I know you pepole have tried to break things into more understandable and easy format. And God bless you. Keep it up

i found this document so useful towards my study in research methods. thanks so much.

This is my 2nd read topic in your course and I should commend the simplified explanations of each part. I’m beginning to understand and absorb the use of each part of a dissertation/thesis. I’ll keep on reading your free course and might be able to avail the training course! Kudos!

Thank you! Better put that my lecture and helped to easily understand the basics which I feel often get brushed over when beginning dissertation work.

This is quite helpful. I like how the Golden thread has been explained and the needed alignment.

This is quite helpful. I really appreciate!

The article made it simple for researcher students to differentiate between three concepts.

Very innovative and educational in approach to conducting research.

I am very impressed with all these terminology, as I am a fresh student for post graduate, I am highly guided and I promised to continue making consultation when the need arise. Thanks a lot.

A very helpful piece. thanks, I really appreciate it .

Very well explained, and it might be helpful to many people like me.

Wish i had found this (and other) resource(s) at the beginning of my PhD journey… not in my writing up year… 😩 Anyways… just a quick question as i’m having some issues ordering my “golden thread”…. does it matter in what order you mention them? i.e., is it always first aims, then objectives, and finally the questions? or can you first mention the research questions and then the aims and objectives?

Thank you for a very simple explanation that builds upon the concepts in a very logical manner. Just prior to this, I read the research hypothesis article, which was equally very good. This met my primary objective.

My secondary objective was to understand the difference between research questions and research hypothesis, and in which context to use which one. However, I am still not clear on this. Can you kindly please guide?

In research, a research question is a clear and specific inquiry that the researcher wants to answer, while a research hypothesis is a tentative statement or prediction about the relationship between variables or the expected outcome of the study. Research questions are broader and guide the overall study, while hypotheses are specific and testable statements used in quantitative research. Research questions identify the problem, while hypotheses provide a focus for testing in the study.

Exactly what I need in this research journey, I look forward to more of your coaching videos.

This helped a lot. Thanks so much for the effort put into explaining it.

What data source in writing dissertation/Thesis requires?

What is data source covers when writing dessertation/thesis

This is quite useful thanks

I’m excited and thankful. I got so much value which will help me progress in my thesis.

where are the locations of the reserch statement, research objective and research question in a reserach paper? Can you write an ouline that defines their places in the researh paper?

Very helpful and important tips on Aims, Objectives and Questions.

Thank you so much for making research aim, research objectives and research question so clear. This will be helpful to me as i continue with my thesis.

Thanks much for this content. I learned a lot. And I am inspired to learn more. I am still struggling with my preparation for dissertation outline/proposal. But I consistently follow contents and tutorials and the new FB of GRAD Coach. Hope to really become confident in writing my dissertation and successfully defend it.

As a researcher and lecturer, I find splitting research goals into research aims, objectives, and questions is unnecessarily bureaucratic and confusing for students. For most biomedical research projects, including ‘real research’, 1-3 research questions will suffice (numbers may differ by discipline).

Awesome! Very important resources and presented in an informative way to easily understand the golden thread. Indeed, thank you so much.

Well explained

The blog article on research aims, objectives, and questions by Grad Coach is a clear and insightful guide that aligns with my experiences in academic research. The article effectively breaks down the often complex concepts of research aims and objectives, providing a straightforward and accessible explanation. Drawing from my own research endeavors, I appreciate the practical tips offered, such as the need for specificity and clarity when formulating research questions. The article serves as a valuable resource for students and researchers, offering a concise roadmap for crafting well-defined research goals and objectives. Whether you’re a novice or an experienced researcher, this article provides practical insights that contribute to the foundational aspects of a successful research endeavor.

A great thanks for you. it is really amazing explanation. I grasp a lot and one step up to research knowledge.

I really found these tips helpful. Thank you very much Grad Coach.

I found this article helpful. Thanks for sharing this.

thank you so much, the explanation and examples are really helpful

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Research Questionnaire

Questionnaire generator.

When a researcher creates a research paper using the scientific method they will need to use a gathering method that is adjacent to the research topic. This means that the researcher will use a quantitative research method for a quantitive topic and a qualitative method for a qualitative  one.  The research questionnaire is one of the quantitative data-gathering methods a researcher can use in their research paper.

1. Market Research Questionnaire Template Example

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What Is a Research Questionnaire?

A research questionnaire is a physical or digital questionnaire that researchers use to obtain quantitative data. The research questionnaire is a more in-depth version of a survey   as its questions often delve deeper than survey questions .

How to Write a Research Questionnaire

A well-made research questionnaire can effectively and efficiently gather data from the population. Creating a good research questionnaire does not require that many writing skills , soft skills , or hard skills , it just requires the person to properly understand the data set they are looking for.

Step 1: Select a Topic or Theme for the Research Questionnaire

Begin by choosing a topic or theme   for the research questionnaire as this will provide much-needed context for the research questionnaire. Not only that but the topic will also dictate the tone of the questions in the questionnaire.

Step 2: Obtain or Use a Research Questionnaire Outline

You may opt to use a research questionnaire outline or outline format for your research questionnaire. This outline will provide you with a structure you can use to easily make your research questionnaire.

Step 3: Create your Research Questionnaire

Start by creating questions that will help provide you with the necessary data to prove or disprove your research question. You may conduct brainstorming sessions to formulate the questions for your research questionnaire.

Step 4: Edit and Have Someone Proofread the Questionnaire

After you have created and completed the research questionnaire, you must edit the contents of the questionnaire. Not only that but it is wise to have someone proofread the contents of your questionnaire before deploying the questionnaire. 

How does a research questionnaire help businesses?

A successful business or company utilizes research questionnaires to not only obtain data from their customers but also to gather data about the performance and quality of the employees in the business. The research questionnaire provides the business or company with actionable data, which they can use to improve the product, service, or commodity to obtain more customers.

Do I need to provide a consent form when I ask someone to answer the research questionnaire?

Yes, consent is very important as without this the data you have gathered from your questionnaires or surveys are useless. Therefore it is important to provide a consent form with your research questionnaire when you are asking a participant to answer the document.

What type of answers are allowed in the research questionnaire?

Research questionnaires can host a multitude of types of questions each with its specific way of answering.  A questionnaire can use multiple-choice questions, open-ended questions, and closed questions. Just be sure to properly pace the questions as having too many different types of answering styles can demotivate or distract the target audience, which might lead to errors.

A research questionnaire is a data-gathering document people can use to obtain information and data from a specific group of people. Well-made and crafted research questionnaires will provide much-needed information one can use to answer a specific research question.

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Gene variants foretell the biology of future breast cancers in Stanford Medicine study

In a finding that vastly expands the understanding of tumor evolution, researchers discover genetic biomarkers that can predict the breast cancer subtype a patient is likely to develop.

May 30, 2024 - By Krista Conger

Stanford Medicine researchers found that inherited gene sequences can predict what type of breast cancer a patient is likely to develop, along with how aggressive that cancer may be.   Emily Moskal

A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the breast cancer type we might develop decades later and how deadly it might be.

The study challenges the dogma that most cancers arise as the result of random mutations that accumulate during our lifetimes. Instead, it points to the active involvement of gene sequences we inherit from our parents — what’s known as your germline genome — in determining whether cells bearing potential cancer-causing mutations are recognized and eliminated by the immune system or skitter under the radar to become nascent cancers. 

“Apart from a few highly penetrant genes that confer significant cancer risk, the role of hereditary factors remains poorly understood, and most malignancies are assumed to result from random errors during cell division or bad luck,” said Christina Curtis , PhD, the RZ Cao Professor of Medicine and a professor of genetics and of biomedical data science. “This would imply that tumor initiation is random, but that is not what we observe. Rather, we find that the path to tumor development is constrained by hereditary factors and immunity. This new result unearths a new class of biomarkers to forecast tumor progression and an entirely new way of understanding breast cancer origins.”

Curtis is the senior author of the study, which will be published May 31 in Science . Postdoctoral scholar Kathleen Houlahan , PhD, is the lead author of the research.

“Back in 2015, we had posited that some tumors are ‘born to be bad’ — meaning that their malignant and even metastatic potential is determined early in the disease course,” Curtis said. “We and others have since corroborated this finding across multiple tumors, but these findings cast a whole new light on just how early this happens.”

A new take on cancer’s origin

The study, which gives a nuanced and powerful new understanding of the interplay between newly arisen cancer cells and the immune system, is likely to help researchers and clinicians better predict and combat breast tumors.

Currently, only a few high-profile cancer-associated mutations in genes are regularly used to predict cancers, but these account for a small minority of cases. Those include BRCA1 and BRCA2, which occur in about one of every 500 women and confer an increased risk of breast or ovarian cancer, and rarer mutations in a gene called TP53 that causes a disease called Li Fraumeni syndrome, which predisposes to childhood and adult-onset tumors.

Christina Curtis

The findings suggest there are tens or hundreds of additional gene variants — identifiable in healthy people — that through interactions with the immune system pull the strings that determine why some people remain cancer-free throughout their lives.

“Our findings not only explain which subtype of breast cancer an individual is likely to develop,” Houlahan said, “but they also hint at how aggressive and prone to metastasizing that subtype will be. Beyond that, we speculate that these inherited variants may influence a person’s risk of developing breast cancer. However, future studies will be needed to examine this.”  

The genes we inherit from our parents are known as our germline genome. They’re mirrors of our parents’ genetic makeup, and they can vary among people in small ways that give some of us blue eyes, brown hair or type O blood. Some inherited genes include mutations that confer increased cancer risk from the get-go, such as BRCA1, BRCA2 and TP53.

In contrast, most cancer-associated genes are part of what’s known as our somatic genome. As we live our lives, our cells divide and die in the tens of millions. Each time the DNA in a cell is copied, mistakes happen and mutations can accumulate. DNA in tumors is often compared with the germline genomes in blood or normal tissues in an individual to pinpoint which changes likely led to the cell’s cancerous transformation.

Classifying breast cancers

In 2012, Curtis began a deep dive — assisted by machine learning — into the types of somatic mutations that occur in thousands of breast cancers. She was eventually able to categorize the disease into 11 subtypes with varying prognoses and risk of recurrence, finding that four of the 11 groups were significantly more likely to recur even 10 or 20 years after diagnosis — critical information for clinicians making treatment decisions and discussing long-term prognoses with their patients.

Prior studies had shown that people with inherited BRCA1 mutations tend to develop a subtype of breast cancer known as triple negative breast cancer. This correlation implies some behind-the-scenes shenanigans by the germline genome that affects what subtype of breast cancer someone might develop.

“We wanted to understand how inherited DNA might sculpt how a tumor evolves,” Houlahan said. To do so, they took a close look at the immune system.

It’s a quirk of biology that even healthy cells routinely decorate their outer membranes with small chunks of the proteins they have bobbing in their cytoplasm — an outward display that reflects their inner style.

Kathleen Houlahan

The foundations for this display are what’s known as HLA proteins, and they are highly variable among individuals. Like fashion police, immune cells called T cells prowl the body looking for any suspicious or overly flashy bling (called epitopes) that might signal something is amiss inside the cell. A cell infected with a virus will display bits of viral proteins; a sick or cancerous cell will adorn itself with abnormal proteins. These faux pas trigger the T cells to destroy the offenders.

Houlahan and Curtis decided to focus on oncogenes, normal genes that, when mutated, can free a cell from regulatory pathways meant to keep it on the straight and narrow. Often, these mutations take the form of multiple copies of the normal gene, arranged nose to tail along the DNA — the result of a kind of genomic stutter called amplification. Amplifications in specific oncogenes drive different cancer pathways and were used to differentiate one breast cancer subtype from another in Curtis’ original studies.

The importance of bling

The researchers wondered whether highly recognizable epitopes would be more likely to attract T cells’ attention than other, more modest displays (think golf-ball-sized, dangly turquoise earrings versus a simple silver stud). If so, a cell that had inherited a flashy version of an oncogene might be less able to pull off its amplification without alerting the immune system than a cell with a more modest version of the same gene. (One pair of overly gaudy turquoise earrings can be excused; five pairs might cause a patrolling fashionista T cell to switch from tutting to terminating.)

The researchers studied nearly 6,000 breast tumors spanning various stages of disease to learn whether the subtype of each tumor correlated with the patients’ germline oncogene sequences. They found that people who had inherited an oncogene with a high germline epitope burden (read: lots of bling) — and an HLA type that can display that epitope prominently — were significantly less likely to develop breast cancer subtypes in which that oncogene is amplified.

There was a surprise, though. The researchers found that cancers with a large germline epitope burden that manage to escape the roving immune cells early in their development tended to be more aggressive and have a poorer prognosis than their more subdued peers.

“At the early, pre-invasive stage, a high germline epitope burden is protective against cancer,” Houlahan said. “But once it’s been forced to wrestle with the immune system and come up with mechanisms to overcome it, tumors with high germline epitope burden are more aggressive and prone to metastasis. The pattern flips during tumor progression.”

“Basically, there is a tug of war between tumor and immune cells,” Curtis said. “In the preinvasive setting, the nascent tumor may initially be more susceptible to immune surveillance and destruction. Indeed, many tumors are likely eliminated in this manner and go unnoticed. However, the immune system does not always win. Some tumor cells may not be eliminated and those that persist develop ways to evade immune recognition and destruction. Our findings shed light on this opaque process and may inform the optimal timing of therapeutic intervention, as well as how to make an immunologically cold tumor become hot, rendering it more sensitive to therapy.”

The researchers envision a future when the germline genome is used to further stratify the 11 breast cancer subtypes identified by Curtis to guide treatment decisions and improve prognoses and monitoring for recurrence. The study’s findings may also give additional clues in the hunt for personalized cancer immunotherapies and may enable clinicians to one day predict a healthy person’s risk of developing an invasive breast cancer from a simple blood sample.

“We started with a bold hypothesis,” Curtis said. “The field had not thought about tumor origins and evolution in this way. We’re examining other cancers through this new lens of hereditary and acquired factors and tumor-immune co-evolution.”

The study was funded by the National Institutes of Health (grants DP1-CA238296 and U54CA261719), the Canadian Institutes of Health Research and the Chan Zuckerberg Biohub.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

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Tracking tiny stowaways, getting there and back, refining radiation detection, robot helpers.

Space, the saying goes, is hard. And the farther humans go, the harder it can get.

Some of the challenges on missions to explore the Moon and Mars include preventing microbial contamination of these destinations, navigating there safely, protecting crew members and hardware from radiation, and maintaining and repairing equipment.

Research on the International Space Station is helping NASA scientists develop tools and processes to ensure success on these important missions. Here are highlights from some of the investigations making space a little easier.

Bacteria and fungi live in and on all humans and all around us on Earth. Most of these microorganisms are beneficial or harmless but introducing them to other celestial bodies could adversely affect our ability to study ecosystems on those other worlds.

Crew members will conduct a spacewalk to collect samples near space station life support system vents for ISS External Microorganisms , an investigation to assess whether the orbiting laboratory releases microorganisms into space. Results could provide insight into the potential for organisms to survive and reproduce in space and help researchers determine which microbes would most likely contaminate other planetary bodies visited by crewed missions.

A miniature, hand-held digital microscope designed to make in-flight medical diagnoses, the Moon Microscope , also can test water, food, and surfaces for contamination. The device images samples at high resolution and processes data on web-enabled devices such as phones or tablets. Multiple users can access the microscope simultaneously, and some applications run autonomously.

Spacecraft must have sophisticated high-tech systems for navigating. Sextant Navigation tests the function of sextants in microgravity as an emergency backup navigation technique for Artemis and other future exploration missions. These mechanical devices have guided navigators for centuries, and Gemini and Apollo missions demonstrated they were useful for astronauts.

Missions beyond low Earth orbit increase exposure to radiation, which can pose a hazard to human health and interfere with equipment operation. As NASA prepares for future missions, providing adequate protection is vital.

The Hybrid Electronic Radiation Assessor, or HERA, was built to serve as a primary radiation detection system for the Orion spacecraft, which will carry crews into orbit around the Moon. The International Space Station Hybrid Electronic Radiation Assessor investigation modified the system to operate on the space station to provide researchers input for use on future exploration missions.

Artemis HERA on Space Station further modified the radiation detection system so researchers could continue to evaluate the hardware in the space radiation environment prior to Artemis II.

Active-Dosimeters , an investigation led by ESA (European Space Agency), tested a wearable system to measure radiation exposure to crew members on the space station and how it changes with the station’s orbit and altitude. Data from the wearable dosimeter improved radiation risk assessments and could lead to better protection for astronauts, including the ability to quickly respond to changes in exposure throughout future exploration missions.

On future exploration missions, robotic technology can help crew members with basic tasks, monitor and maintain equipment, and conduct operations such as sample collection, reducing the need to expose astronauts to harsh environments. Integrated System for Autonomous and Adaptive Caretaking demonstrates using autonomous robots to transfer and unpack cargo and to track and respond to maintenance issues such as leaks and fires, which could protect valuable equipment and reduce costly repairs on future missions. The investigation uses the space station’s Astrobee and Robonaut robots.

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Formulating a researchable question: A critical step for facilitating good clinical research

Sadaf aslam.

Clinical and Translational Science Institute and Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL, USA

Patricia Emmanuel

Developing a researchable question is one of the challenging tasks a researcher encounters when initiating a project. Both, unanswered issues in current clinical practice or when experiences dictate alternative therapies may provoke an investigator to formulate a clinical research question. This article will assist researchers by providing step-by-step guidance on the formulation of a research question. This paper also describes PICO (population, intervention, control, and outcomes) criteria in framing a research question. Finally, we also assess the characteristics of a research question in the context of initiating a research project.

INTRODUCTION

A researchable question is an uncertainty about a problem that can be challenged, examined, and analyzed to provide useful information.[ 1 ] A successful research project depends upon how well an investigator formulates the research question based on the problems faced in day-to-day research activities and clinical practice. The underlying questions of a research project provide important information to decide whether the topic is relevant, researchable, and significant. A well-formulated research question needs extreme specificity and preciseness which guides the implementation of the project keeping in mind the identification of variables and population of interest. Here we will present a clinical scenario and see how clinical questions arise and help us in finding the evidence to answer our question.

FORMULATING THE RESEARCH QUESTION

A 2-year-old boy presents in an outpatient clinic with fever and severe pain in his right ear. He has a history of recurrent ear infections, and his mother expresses a concern that he has been on the antibiotic amoxicillin for the past few weeks. She is worried about the consequences of the long-term antibiotic use. She is also concerned about the outcome associated with recurrent ear infections. She wants to know if the prescribed amoxicillin is effective, or it can be substituted with another antibiotic because of its side effects such as frequent diarrhea.

Several questions arise from this case which can be broadly classified into background and foreground questions. The general questions about a clinical problem or a disease are called “Background Questions.”[ 2 ] These questions generally ask what, when, how, and where about the disease, disorder, or treatment for instance, “What is otitis media?” or “How does amoxicillin work?” etc. These types of questions can be answered by going through review articles or text books.

The patient-oriented questions involving interpretation of a therapy or disease and consideration of risk vs. benefit for a patient or a group of patient are called “Foreground Questions.”[ 2 ] These types of complex clinical questions are best answered by primary or pre-assessed studies in the literature. These questions mostly compare the two, either two drugs or treatments or two diagnostic methods, etc.

The PICO (population, intervention, control, and outcomes) format [ Table 1 ] is considered a widely known strategy for framing a “foreground” research question.[ 3 ] Sackett et al . pointed out that breaking the question into four components will facilitate the identification of relevant information.

Considering PICO and FINER criteria for developing a research question[ 3 , 5 ]

Population or problem - addressing a specific population, its important characteristics and demographic information. From the above case, you can identify pediatric population with otitis media, the age range, sex, presenting complaint, and history.

Intervention or treatment of interest - the intervention can be a treatment, procedure, diagnostic test, and risk or prognostic factors. In this case, the intervention will be your plan to treat the patient which can be a new therapy, a diagnostic test, prognostic factor, or a procedure. For example, based on your observation in clinic, cefuroxime is another better treatment option as compared to amoxicillin in treating otitis media but you are not sure about its efficacy in pediatric population with otitis media.

Comparator or control -when a new therapy is compared with the existing one.

Outcome - is the effect of the intervention. For example, its effectiveness in controlling pain. Therefore, the outcome in the above case can be the relief of pain, the resolution of infection, or decreasing the risk of developing resistance. A good primary outcome should be easily quantifiable, specific, valid, reproducible, and appropriate to your research question.[ 4 ]

In a typical clinical setting, a clinician needs to know about background and foreground questions depending upon the experience about a particular disease and therapy. Once background questions are answered, more complex questions are addressed. The clinical questions arise from the central issues in a clinical work.[ 2 ] For example, identifying causes or risk factors (etiological questions), comparing diagnostic tests based on sensitivity and specificity (diagnostic query), identifying best treatment options (therapeutic question), and outcome of the treatment (prognostic question).

After determining a foreground question, the PICO approach is followed. Dissecting the question into parts makes it easy and searchable. As evident in this case, there are several relevant questions, for example: what are the outcomes associated with recurrent ear infection, what are the possible effects of long-term use of antibiotic, and what are the harms associated with current treatment? Now if you gather all the information from PICO approach, the following researchable questions can be formulated.

In children with acute otitis media (P), is cefuroxime (I) effective in reducing the duration of symptoms (O) as compared to amoxicillin (C)?

In children suffering from otitis media, will cefuroxime result in the improvement of symptoms and reduction in developing resistance?

Does treatment with amoxicillin increase the risk of developing resistance in children suffering from otitis media?

Does surgical procedure has better outcome for the treatment of otitis media in children after repeated antibiotic therapy?

From the above case, we have formulated multiple questions based on our patient’s illness and concerns. Now we can use the strategy of “selecting” the best question.[ 2 ] For example, which question has more significance for the patient’s well-being, which question is relevant to our knowledge needs and which question might lead to interesting answers for our patients and clinical query? Further, we need to consider the feasibility of finding the evidence in a short period.

ASSESSING THE RESEARCH QUESTION IN THE CONTEXT OF A STUDY DESIGN

As proposed by Hulley et al . [ Table 1 ], a research question should be formulated keeping in mind the FINER (feasible, interesting, novel, ethical, and relevant) criteria[ 5 ] and that the answer should fill gaps in the existing knowledge. The following points should be considered while assessing a research question.

Determining the required resources

The feasibility of conducting a research project is based on the research question and should be considered early in the process in order to avoid waste of resources and intellectual energy. This is sometimes difficult for a new investigator and they need guidance from their mentors.[ 4 ]

• Consider doing a pilot or proof of concept study to asses the feasibility;
• Consult a biostatistician early in the project in order to choose less costly design and common outcomes;
• Consider feasibility of enrolling the intended number of subjects from the population of your interest. Also, consider expanding your inclusion criteria and modifying exclusion criteria if it is difficult to enroll the intended number; and
• Consider cost of each element of the study design, research staff, and resources.

Significance of making it interesting and relevant

An important question may not seem interesting the way it is presented. It is a challenge to present a research question clearly and engage the interest and attention of the reviewers. Research is too much work to not have a passion for what you are investigating. You will have more support for your study, and it will be easier to publish if the topic is novel and also interests your collaborators, colleagues, and the community at large. It is important to pursue a research question with a passion of getting the truth out of the matter.[ 5 ] This is how we all perceive research; commitment to a high-quality systematic and unbiased completion of an innovative project. If your question can explain a given problem while pointing toward a specific aspect which is missing then your project can get a great deal of support.

Conducting literature review

The innovation of any research question is determined by a thorough literature search. Any replication of the study already existing in the literature is not worth repeating as it is. Depending upon the research question, sometimes the study can be replicated if your question approaches an existing problem in a refreshing way. This can be achieved by using a different populations, different techniques, new conceptual approaches, or linking two different studies in which outcomes did not solve the problem.[ 5 ] Once a preliminary question has been formulated, literature search should be done to find out what is known or unknown about the topic. The goal of the literature review is to determine what research has been conducted on the topic of interest? and how has it been conducted? and what are the gaps in the knowledge?. It is recommended to use PubMed, MedlinePlus, CINAHL, or Web of Science as the main search databases, but other databases can be used as well. PubMed clinical query is an easy and user-friendly database to search for evidence related to clinical practice. This also provides information to search MEDLINE by doing categorical searches, for example, therapeutic, diagnostic, etiological, and prognostic. The American College of Physicians (ACP) and clinical evidence from BMJ Publishing Group are excellent systems to find evidence on therapeutic questions. Other search engines such as OVID has a large selection of texts and journals which provides access to other databases such as Cochrane library in getting full text articles and systematic reviews. Gray et al . suggested 4 Ss for literature review: Systems : use of comprehensive resources, Synopses : extracting high-quality studies and abstracts, Syntheses: systematic reviews, and Studies : original research studies.[ 6 ] In the hierarchy of evidence-based medicine, systematic reviews are considered the best method for evidence. Systematic reviews are rigorous methods of collecting and synthesizing the results of many high-quality studies. Conducting a thorough literature search also helps in finding information on the methodology, calculating the sample size, and also the type of analysis as we are looking to find a difference. This information is necessary to help structure a new study and to identify gaps in the knowledge base of the scientific community.

Refining research question

A focused research question leads to a systematic planning of a research project. The difficulty in framing a research question is not due to the lack of ideas. The challenge is to transform a novel research question into a valid study design which is the next step in refining a research question.

Asking a well-formulated research question is a starting point in conducting a quality research project and in evidence-based clinical practice. The framework presented in this paper can be helpful for a clinician to formulate a question and search for an answer and for a researcher to develop a new research project. The classical approach is to identify a research question followed by a thorough literature search keeping in mind the PICO and FINER criteria. If it is a well-defined research question, it will lead to an appropriate study design and methodology. Discussing your research question with knowledgeable peers, department chair, mentor, and the biostatistician from the start will lead to the completion of a successful project. Other steps such as type and phase of the clinical trial, budget, informed consent, sites, resource constraints of both personnel and facilities, and timeline should also be considered while formulating a research question. We have introduced the concept of background and foreground questions and also the types of different questions that can arise (therapy, harm, diagnosis, and prognosis). We have described several strategies here while highlighting the major steps that will help investigators in framing a question with the goal of finding an answer based on evidence or initiation of a new research project. It is always good to focus on a single research question based on its relevance to patient’s health or one primary objective to drive the study design.[ 4 ] Once we have formulated our research question, we need to keep track of the progress toward finding an appropriate answer and then finally applying the results to a specific patient population. In short, a researchable question is what leads toward the facts rather than opinion[ 7 ] and is clearly linked to the overall research project goal.

Acknowledgments

The authors would like to acknowledge Dr. J.K Kosambiya, Dr. Eknath Naik, and Dr. Ambuj Kumar for their time in reviewing the paper and providing useful insights.

Source of Support: Nil

Conflict of Interest: None declared.

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Scientists develop visual tool to help people group foods based on their levels of processing

by Virginia Tech

Fralin Biomedical Research Institute at VTC scientists studying ultra-processed foods have created a new tool for assessing the rewarding and reinforcing properties of foods that make up 58% of calories consumed in the United States. The foods have been linked to a wide range of negative health outcomes.

The research, which was published in April in the journal Appetite , provides a collection of carefully curated images of minimally processed and ultra-processed foods matched on 26 characteristics, including macronutrients, sodium, dietary fiber, calories, price, and visual characteristics such as color and portion size.

The work was based on the NOVA classification system—"nova" means new in Portuguese—which groups foods into four categories based on their level of processing. Nutrition researchers at the University of São Paulo in Brazil developed the scale while studying the country's sharp increase in obesity rates.

The scale has its detractors.

"A major criticism of the NOVA scale is that it's difficult to use or that foods are classified differently by different people," said Alexandra DiFeliceantonio, corresponding author and assistant professor at the Fralin Biomedical Research Institute. "We found that people with education in nutrition generally agreed on the food classifications, providing some data that it might not be a valid criticism."

What they did

The NOVA system assigns food to four categories: unprocessed or minimally processed, such as fresh fruit , legumes, or plain yogurt; processed culinary ingredients, such as cooking oils, butter, and salt; processed foods, which combine the two above through simple methods such as cheese, canned vegetables, or freshly baked bread; and ultra-processed foods, such as soft drinks , flavored yogurt, processed meat, and most packaged breads, made through industrial processing and additives rarely found in a home pantry.

To develop the picture set, a team of psychologists, neuroscientists, and registered dietitians selected foods to represent either minimally processed or ultra-processed foods.

The foods were prepared in a lab, visually represented through professional photography, and controlled for consistency. Researchers also gathered price, food weights, and nutritional information—calories, macronutrients, sodium, and dietary fiber —for the food in each image.

Study participants rated images across a range of qualities to generate a final set of 28 pictures matched across 26 characteristics. To objectively measure NOVA classification, researchers recruited 67 nutrition professionals and asked them to classify the foods as minimally or ultra-processed.

"With this food picture set we can start to infer that any differences between food pictures are due to the degree of food processing, and not all these other factors that we know are potentially impactful," said Zach Hutelin, the study's lead author and a Fralin Biomedical Research Institute-based graduate student in the translational biology, medicine and health Ph.D. program.

Why this matters

Ultra-processed foods are linked with an increased risk of developing obesity, Type 2 diabetes, heart disease, and cancer. They represent more than half of calories consumed in the United States, Canada, and the United Kingdom and have been identified as a global threat to public health .

"There is very little experimental research on ultra-processed foods, and part of what's been holding us back is better tools for measuring and assessing their effects," said DiFeliceantonio, who is also associate director of the Fralin Biomedical Research Institute's Center for Health Behaviors Research. "The more tools we can provide, the more we can learn."

The Virginia Tech team is making the pictures and associated data accessible through the Virginia Tech Data Repository of the Virginia Tech University Libraries. This will allow scientists to test hypotheses in behavioral, economic and neuroimaging studies.

In the DiFeliceantonio lab, the photos are being used with functional MRI to reveal associated brain activity , with the images isolating the effects of food processing from other characteristics.

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Scientists identify gene that could lead to resilient 'pixie' corn

A widely found gene in plants has been newly identified as a key transporter of a hormone that influences the size of corn. The discovery offers plant breeders a new tool to develop desirable dwarf varieties that could enhance the crop's resilience and profitability.

A team of scientists led by Iowa State University spent years working to pinpoint the functions of the gene ZmPILS6. Now, they have been able to characterize it as an important driver of plant size and architecture, a carrier for an auxin hormone that helps govern growth in roots below ground and shoots, or stalks, above ground. Their findings were published in the Proceedings of the National Academy of Sciences ( PNAS ) this week.

"A hallmark of the current age of science is that we have all this high-quality genome data, whether for corn or humans or other organisms, and now we have the task of figuring out what the genes actually do," said Dior Kelley, assistant professor of genetics, development and cell biology at Iowa State, who led the research team.

The group used "reverse genetic screening" (from the gene to traits expressed in the plant), combined with other techniques, as they tracked their gene's role in corn development. Reverse screens require multiple growing seasons and don't always work, according to Kelley. It took seven years for her group to thoroughly characterize ZmPILS6 and verify it regulates plant growth.

When "knocked out" of modified, mutant plants, its absence suppressed root lateral formation and plant height. The research has led to a provisional patent for its potential to be used in breeding programs to create short stature corn that is still highly productive.

"I think of this as 'pixie' corn," Kelley said. "There's a lot of interest in it for all kinds of reasons, including reduced use of water and nutrients and its ability to withstand high winds."

As they studied ZmPILS6 in corn, the researchers made another curious finding: The gene seemed to have opposite effects on plant growth than a comparable gene in Arabidopsis , a plant often used as a model for research.

"This was very unexpected," Kelley said. "It illustrates that plant proteins, which have evolved in different contexts, can behave differently. It emphasizes the need to study genes directly within key crops of interest, rather than thinking we understand them based on how they work in other plants."

Kelley gives a lot of the credit for the project's success to a "great team of collaborators," especially Craig Cowling, a doctoral student in Kelley's lab who is the first author on the PNAS paper. "Craig was the one to really dig in, to confirm that this gene carries the plant hormone auxin, and it absolutely controls size in corn."

"This project and being acknowledged as first author on a paper in this important journal has been a little unbelievable," Cowling said. "It's been a long journey for me. I never thought I would go to college when I was in high school in Des Moines, so I went into ROTC and then the Marines, where I worked around the world as a technology specialist. When I got out, I wanted to do something different. Thanks to some good mentors, I've figured out that I love working with and understanding plants."

Kelley calls the new research "foundational" basic research to understand a gene that impacts numerous, complex growth traits, which evolution has conserved through many plants, from algae to maize. "It is also 'translational,' in that it links to genetic resources that can be used to improve breeding programs," she said. "This opens up whole new questions and facets of research for my laboratory."

This project has been supported by an Agriculture and Food Research Initiative competitive grant through the USDA National Institute of Food and Agriculture and USDA Hatch start-up funding from Iowa State University's College of Agriculture and Life Sciences.

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• Agriculture and Food
• Food and Agriculture
• Biotechnology and Bioengineering
• Plant breeding
• Plant defense against being eaten
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Story Source:

Materials provided by Iowa State University . Note: Content may be edited for style and length.

Journal Reference :

• Craig L. Cowling, Arielle L. Homayouni, Jodi B. Callwood, Maxwell R. McReynolds, Jasper Khor, Haiyan Ke, Melissa A. Draves, Katayoon Dehesh, Justin W. Walley, Lucia C. Strader, Dior R. Kelley. ZmPILS6 is an auxin efflux carrier required for maize root morphogenesis . Proceedings of the National Academy of Sciences , 2024; 121 (22) DOI: 10.1073/pnas.2313216121

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