case study 2 biochemistry unimas

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Case Studies: Biochemistry

All biochemistry cases.

Dystrophin Stability and Cardiomyopathy

By Richard J. Kwak, Joyce A. Horton, Zyan Davis, Kristy J. Wilson

A Bioinformatic Investigation of a Mysterious Meningoencephalitis

By Sari Matar, Dyan Anore, Basma Galal, Shawn Xiong

Diabetic Ketoacidosis Upon Diagnosis

By Ali Chaari, Aisha Kafoud

Can Stem Cells Bring Magic to Medicine?

By Ashleigh Garrett, Joni H. Ylostalo

Not the NMR You Are Thinking of

By Shawn Xiong

Is p53 a Smoking Gun?

By Michèle I. Shuster, Joann Mudge, Meghan Hill, Katelynn James, Gabriella A. DeFrancesco, Maria P. Chadiarakou, Anitha Sundararajan

Liam’s Head Injury

By Melody J. Neumann, Michelle B. French, Franco A. Taverna

Metabolic Mayhem

By Theresa L. Beaty

Life in the Fat Lane

By Scott J. Donnelly

Atkins or Ammonia?

By Stephanie Dingwall, Tammy Nguyen

Dr. Angela Anak Siner

Highlighted Research Project (10 Best/latest Project)

In progress

• Plasmodium knowlesi gametocyte burden among malaria patients at Kapit Hospital.
• Spatial-temporal analysis of malaria and the effect of environmental and personal factors for malaria infection in the Betong Division of Sarawak, Malaysian Borneo.
• Epidemiology of knowlesi and other simian malarias in humans in the Betong Division of Sarawak. 
• Efficacy and in vitro activity of traditional medicines used in malaria endemic regions of Borneo.

Highlighted Publication (10 best/latest publication: (Journal paper/book/modules, etc)

Peer-reviewed journals

Siner A , Liew S-T, Kadir KA, Mohamad DSA, Thomas FK, Zulkarnaen M, Singh B. (2017) Absence of Plasmodium inui and Plasmodium cynomolgi , but detection of Plasmodium knowlesi and Plasmodium vivax infections in asymptomatic humans in the Betong division of Sarawak, Malaysian Borneo. Mal J 16: 417.

Ahmed AM, Pinheiro MM, Divis PC, Siner A , Zainudin R., Wong IT, Lu CW, Singh-Khaira SK, Millar SB, Lynch S, Willmann M, Singh B, Krishna S & Cox-Singh J. (2014) Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members. PLoS Negl Trop Dis , 8: e3086.

Farrah A Fatih, Henry M Staines, Angela Siner , Mohammed Atique Ahmed, Lu Chan Woon, Erica M Pasini, Clemens HM Kocken, Balbir Singh, Janet Cox-Singh and Sanjeev Krishna. (2013) Susceptibility of human Plasmodium knowlesi infections to anti-malarials. Mal J 12: 425.

Fatih, F. A., Siner, A ., Ahmed, A., Woon, L. C., Craig, A. G., Singh, B., Krishna, S. and J Cox-Singh. (2012) Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. Mal J 11: 33.

Willmann, M., Ahmed, A., Siner, A ., Wong, I. T., Woon, L. C., Singh, B., Krishna, S. and J Cox-Singh. (2012) Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study. Mal J 11: 363.

Weiling Xue,  Angela Siner , Mark Rance, Koka Jayasimhulu, Glenn Talaska, David Warshawsky (2002) A metabolic activation mechanism of 7H-dibenzo[ c,g ]carbazole via o-Quinone. Part 2: covalent adducts of 7H-dibenzo[ c,g ]carbazole-3,4-dione with nucleic acid bases and nucleosides. Chemical Research Toxicology 15(7): 915-21.

Angela Siner , Weiling Xue, Glenn Talaska, David Warshawsky, Deborah L. Gray, Ronald Nines, Yian Wang, Ruisheng Yao, Gary D. Stoner (2002) The effect of 7H-dibenzo[ c,g ]carbazole and benzo[ a ]pyrene mixture on DNA adduct formation in strain A/J mouse model: preliminary report. Polycyclic Aromatic Compounds 22: 893-7.

Christopher Peterson, Jennifer Kordich, Laura Milligan, Erika Bodor,  Angela Siner , Kristin Nagy, Charlotte Elder Paquin (2000) Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae . Environmental and Molecular Mutagenesis 36:325-34

Muna Sabri, Zunika Amit, Angela Siner and John Candlish (2005) Hit the mark: questions on medical biochemistry, UNIMAS Publication: Kota Samarahan.

Grant (international/Local)

National-level

Fundamental Research Grant Scheme, Ministry of Higher Education (September 2019 – October 2021). Plasmodium knowlesi gametocyte burden among malaria patients at Kapit Hospital. Role: Principal Investigator.

Fundamental Research Grant Scheme, Ministry of Higher Education (2013-2015). Epidemiology of knowlesi and other simian malarias in humans in the Betong Division of Sarawak. Role: Principal Investigator.

UNIMAS-level

Special MyRA Assessment Funding, Universiti Malaysia Sarawak (August 2018 - October 2020). Spatial-temporal analysis of malaria and the effect of environmental and personal factors for malaria infection in the Betong Division of Sarawak, Malaysian Borneo.Role: Principal Investigator.

Short Term Grant Scheme, Universiti Malaysia Sarawak (2005-2007). Efficacy and in vitro activity of traditional medicines used in malaria endemic regions of Borneo. Role: Principal Investigator.

Consultation work (Research/Clinical)

Manuscript reviewer for:

- Tropical Biomedicine (November 2018)

- American Journal of Tropical Medicine (April 2020)

- External examiner for Diploma in Medical Laboratory Technology, SEGi College Sarawak, April 2017-April 2019

Awards (Academic/Research)

Merit Award, Technology & Engineering category, Innovation and Technology Expo 2019 (InTEX19), Kuching

Anugerah Perkhidmatan Cemerlang, Majlis Anugerah Gemilang UNIMAS (MAGU) 2014

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INTRODUCTION

Programme educational objective (peo).

• Knowledgeable and technically competent in the field of chemistry in line with industry requirement locally and globally.
• Effective in communication, perform well as a team player and demonstrate good leadership qualities in an organisation.
• Capable to solve problems related to the field of chemistry, creatively, innovatively, ethically, using numerical and technical skills, and through sustainable approach.
• Able to demonstrate entrepreneurship skills and recognise the need of lifelong learning, as well using a broad range of information, media and technology applications for successful career advancement.

Programme Learning Outcomes (PLO)

• Describe fundamental knowledge and principles in chemistry and its application
• Apply critical thinking to solve problems related to chemistry using scientific approach
• Demonstrate practical skills in chemistry through experiment, case study, and research
• Work effectively in a team in diverse learning and working communities in the field of chemistry as well as other groups locally and internationally
• Relate ideas both in written or orally using appropriate forms of presentation confidently, accurately and coherently in a well-structured manner to a diversity of audiences
• Use a broad range of information, media and technology applications to support study and/or work
• Integrate numerical and graphical/visual data for study/work
• Work autonomously, and demonstrate decision making capacities, accountabilities, leadership and professionalism within broad organizational parameters
• Demonstrate self directed lifelong learning for professional development
• Demonstrate entrepreneurial competency with selected projects, including appreciation of broader socio-economic issues at local/national level
• Demonstrate professionalism, positive values, good attitudes and good etiquette as a chemist

Associate Professor Dr. Devagi a/p Kanakaraju | Phone : +6082-583023 | Email : [email protected]

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Case Studies: Proteins

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• Angiotnesin Peptide
• Enkephalines
• Membrane Transport Membrane transport is essential for cellular life. As cells proceed through their life cycle, a vast amount of exchange is necessary to maintain function.  Transport may involve the incorporation of biological molecules and the discharge of waste products that are necessary for normal function. 1 Membrane transport refers to the movement of particles (solute) across or through a membranous barrier. 2 These membranous barriers, in the case of the cell for example, consist of a phospholipid bilayer. The phospholipids orient themselves in such a way so that the hydrophilic (polar) heads are nearest the extracellular and intracellular mediums, and the hydrophobic (non-polar) tails align between the two hydrophilic head groups. Membrane transport is dependent upon the permeability of the membrane, transmembrane solute concentration, and the size and charge of the solute. 2 Solute particles can traverse the membrane via three mechanisms: passive, facilitated, and active transport. 1 Some of these transport mechanisms require the input of energy and use of a transmembrane protein, whereas other mechanisms do not incorporate secondary molecules. 3
• Permanent Hair Wave The formation of disulfide bonds has a direct application in producing curls in hair by the permanent wave process. Hair keratin consists of many protein alpha-helices. Three alpha-helices are interwoven into a left-handed coil called a protofibril. Eleven protofibrils are bonded and coiled together to make a microfibril. Hundreds of these microfibrils are cemented into an irregular bundle called a macrofibril. These in turn are mixed with dead and living cells to make a complete strand of hair.
• Sickle Cell Anemia The incorrect amino acid sequence in a protein may lead to fatal consequences. For example, the inherited disease, sickle cell anemia, results from a single incorrect amino acid at the 6th position of the beta - protein chain out of 146. Hemoglobin consists of four protein chains - two beta and two alpha.

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