buffalo case study chemistry

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All Case Studies

Cases (only) are freely accessible; subscription is required for access to teaching notes and answer keys..

Suggested Keywords, to help with your search (besides selecting subjects): clicker cases, directed cases, interrupted cases, discussion cases, intimate debate cases. As a reminder, all cases may be adjusted to meet the needs of your student level. See our case use guidelines.

Grade level filtering: enter desired grade levels in the Keywords box and click Apply .

Suminoe Oysters Redux

By Matthew L. Simon

Forests for Lemurs

By Ariadna Mondragon-Botero, Susan M. Galatowitsch

Beaker Has a UTI

By Melissa S. Kosinski-Collins, Kene Piasta, Martin Samuels, Ariana Hinckley-Boltax

The Organic Chemistry of Drug Design in a Case of Schizophrenia

By Brahmadeo Dewprashad, Vishnu Tiwari

A Long Recovery Road for Norrie

By Melissa S. Kosinski-Collins , Caitlin M. Hepps Keeney, Ariana L. Hinckley-Boltax 

Dystrophin Stability and Cardiomyopathy

By Richard J. Kwak, Joyce A. Horton, Zyan Davis, Kristy J. Wilson

A Bioinformatic Investigation of a Mysterious Meningoencephalitis

By Sari Matar, Dyan Anore, Basma Galal, Shawn Xiong

Diabetic Ketoacidosis Upon Diagnosis

By Ali Chaari, Aisha Kafoud

The Name’s Bond, Chemical Bond

By Katie McShea, Kari Fleuriet, Fatmah Alamoudi, Deana Jaber

The Baby Who Had No Baby Fat

By Sheri L. Boyce

Maria, Metastasis, and Methotrexate

By Rachael M. Barry, Matthew Mahavongtrakul, Ray Ghorbani, Suzanne Bohlson

No Longer Long in the Tooth

By Alison J. Albee, J. Megan Woltz, Taylor Kemp, Emma Mays, Tylor M. Miller, Eric Fisher, Amanda Loutzenhiser

Does Jazmyne Need a New Chair?

By Melissa S. Kosinski-Collins , Ariana L. Hinckley-Boltax 

By Hollie L. Leavitt

Medication Safety Management

By Hilary Anderson, Shannon Mommsen, Sara Khan, Abir O. Kanaan, Karyn Sullivan, Paul Belliveau

National Center for case study teaching in science

Method assessment.

WHAT DO WE KNOW about case study teaching? The use of problem-based learning (one form of case study teaching) in medical schools has received close scrutiny from researchers. As the use of case-based teaching more broadly increases in undergraduate college and K-12 classrooms, a significant body of literature is beginning to accumulate on the assessment of the method and other active learning pedagogies.

Research Articles

Faculty perceptions on the benefits of case teaching.

We surveyed over 100 science teachers we had trained over a year-and-a-half-long period. One of the things we asked them was what they thought the benefits of case-based teaching were for their students. Here’s what they had to say.

Cases and Critical Thinking

When we teach, we want our students to learn more than just a collection of facts – we also want them to become better critical thinkers. We believe that carefully constructed cases can provide pedagogical tools that teach not only content knowledge, but also critical thinking skills. We are currently engaged in an NSF-funded study that is looking at whether cases can be used to improve students' critical thinking skills.

© 1999-2024 National Center for Case Study Teaching in Science, University at Buffalo. All Rights Reserved.

• Josh Kenney's blog

Teaching Chemistry With Case Studies

Case studies have been a staple of undergraduate and graduate education programs like medicine, law, and business, for many years. They let learners engage with simulated real-world situations, making the content more meaningful and connected to their future careers. 1 As a valuable context-based  learning tool, case studies are becoming more common in secondary science . 2 Here, we'll explore the role that students and instructors play when learning with case studies.

Typically, case studies simulate real-world situations that encourage higher-level thinking based on Bloom's taxonomy. 3 They usually take the form of a short story that outlines a factual-based situation or problem. Students analyze and evaluate the information and discover solutions by way of numerous possible pathways. In general, the students play the role of an expert, consultant, or advisor who is tasked to use their chemistry knowledge and problem-solving skills to offer expert recommendations. 1 For example, in The Golden Drain, 4 a case study developed by Sharma & Wolgang, students are hired as consultants for a chemical company called GoldMaker Enterprises that recently employed a chemist to carry out the company's secret chemical process. Unfortunately, the new hire's yields are insufficient, prompting students to determine how much money the company lost due to the low production yields and then recommend disciplinary action towards the new hire.

As guided inquiry activities, case studies usually include a series of questions that move students towards a final solution. Some of the questions may be very direct (e.g., Find the number of moles of product produced in the reaction?), or they can be more open-ended (e.g., What are possible sources of error with the experimental design?).

As with other problem-based learning and guided inquiry activities, case studies work well in small group settings where learners support each other while traversing a difficult task. The case study is usually distributed to each group as a single copy for all members to collaborate. The instructor acts as a facilitator asking probing questions to support students' understanding and progress towards a solution.

Role of the Instructor

As previously mentioned, the instructor acts as a coach or facilitator when teaching with a case study. Most of the time, they start class with an assignment that helps students read and understand the case. This initial assignment usually involves a series of questions that help students pick out key pieces of information, prompt background research, or solve related sample problems. After the initial assignment, the instructor should periodically initiate a whole class discussion where students communicate the dilemma from their perspective and the progress their group has made toward a solution. Finally, the instructor may individualize the learning experience by supporting struggling students with data analysis or directing underskilled groups towards a possible solution.

Roles of the Students

In the broadest sense, the students' task is to discover a solution to the dilemma presented in the case study. Since case studies are usually elaborate and complicated, it's often necessary to break the task into smaller parts. One way to divide the work is to assign each group member a role; thus, the students can learn practical collaboration methods and manage the considerable workload.

I like to assign groups of three the following roles: (1) The Manager , (2) The Communications Specialist , and (3) The Scribe .

The Manager leads their group and keeps them pointed toward the goal of solving the problem. The Manager is also responsible for making sure the work is correct, so they need to double-check each calculation. The Communications Specialist is mainly responsible for writing out the answers and thinking about how they will verbally express their solution to the class. Finally, The Scribe takes notes that focus on their groups' metacognitive processes. These notes are recorded on a document that the instructor can distribute separate from the case study. The metacognitive notes are an essential part of the learning process because case studies prompt higher-order thinking that is often novel to students. By analyzing their metacognition, students will grow more confident in working through complex and challenging problems like those they find in case studies.

The metacognitive questions relate to three categories of the regulatory skillfulness described by Cooper and Sandi-Urena. 5 Not only do these prompts promote higher-level thinking, but they also move students toward a final solution to the case study.

• What is the problem asking? (rephrase it in your own words)
• What data is important to find the answer?
• Summarize the steps that your group took to get to the final answer.
• Why does your final answer make sense?

Case studies are a fantastic approach to deepen student learning about a topic and improve their problem-solving skills. Although time-consuming (I usually dedicate an entire class period for one case study), I find them a worthwhile activity compared to the standard worksheet or problem set.

Editor’s Note: Josh   includes a reference for   the   National Center for Case Study Teaching in Science (a fantastic collection of case studies). Interested readers may wish to read Scott Donnelly's PICK about this website resource .

Josh shared an example of a case study:  The Golden Drain - A Stoichiometry Case Study

• Lantz, J., & Walczak, M. (1997). The elements of a chemistry case: Teaching chemistry using the case discussion method. The Chemical Educator , 1(6), 1-22.
• National Center for Case Study Teaching in Science (NCCSTS). (n.d.). National Center for Case Study Teaching in Science. Retrieved May 13, 2021, from https://sciencecases.lib.bu ffalo.edu/
• Krathwohl, D. R. (2002). A revision of Bloom's taxonomy: An overview. Theory into practice , 41(4), 212-218.
• Sharma, A. K., & Wolfgang, D. E. (2016). The Golden Drain: A Stoichiometry Case Study for General Chemistry. Chem. Educ , 21, 77-80.
• Cooper, M. M., & Sandi-Urena, S. (2009). Design and validation of an instrument to assess metacognitive skillfulness in chemistry problem solving. Journal of Chemical Education, Vol. 86, 2,  p 240.

Chemler Lab @ UB Chemistry

Organic Synthesis, Catalysis, Medicinal Chemistry, Asymmetric Synthesis

Publications

84. J. J. Kennedy-Ellis, A. D. Kelleher, J. A. Sayeed, A. S. Burde and S. R. Chemler,* ( 2024 ) “Enantioenriched allylesters via a copper-catalyzed diene carboesterification with alkyltrifluoroborates and carboxylic acids,” accepted in J. Org. Chem .

83. S. R. Chemler (2024), “Copper-catalyzed Generation of Nitrogen-centered Radicals and Reactions Thereof,” submitted to Arkivoc as an invited contribution for Prof. Samir Zard’s honorary issue.

82. R. L. L. Carmo, S. L. Galster, T. Wdowik, C. Song, S. R. Chemler* ( 2023 ), “Copper-Catalyzed Enantioselective Aerobic Alkene Aminooxygenation and Dioxygenation: Access to 2-Formyl Saturated Heterocycles and Unnatural Proline Derivatives,” J. Am. Chem. Soc. 2023, 145, 13715-13729. https://pubs-acs-org.gate.lib.buffalo.edu/doi/10.1021/jacs.3c01985

81.  S. R. Chemler* and J. J. Kennedy-Ellis ( 2022 ), “Copper-Catalyzed Alkene Difunctionalizations,” in press , Base-Metal Catalysis, Science of Synthesis, N. Yoshikal, Ed.

80. A. S. Burde, S. R. Chemler* ( 2022) , “Copper-Catalyzed Enantioselective Oxysulfenylation of Alkenols: Synthesis of Arylthiomethyl-Substituted Cyclic Ethers,” ACS Catalysis , 12, 7559-7564.  https://pubs.acs.org/doi/pdf/10.1021/acscatal.2c02214

79. J. Li, R. Lama, S. L. Galster, J. R. Inigo, J. Wu, D. Chandra, S. R. Chemler, X. Wang* ( 2022 ), “Small Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic  Cancer via Degradation of Ferritin Heavy Chain and Mutant p53, Molecular Cancer Therapeutics, 21, 535-545. https://aacrjournals.org/mct/article-abstract/21/4/535/689573/Small-Molecule-MMRi62-Induces-Ferroptosis-and?redirectedFrom=fulltext

78. I. A. Berhane, A. S. Burde, J. J. Kennedy-Ellis, E. Zurek and S. R. Chemler* ( 2021 ), “Copper-Catalyzed Enantioselective Alkene Carboetherification for the Synthesis of Saturated Six-Membered Cyclic Ethers,” Chem. Commun ., 57, 10099-10102. https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc03515k

77. S. R. Chemler,* D. Chen, S. D. Karyakarte, J. M. Shikora, T. Wdowik ( 2021 ), “Transition Metal Catalyzed Aminooxygenation of Alkenes,” Organic Reactions, 108 , 421-962.  https://www.wiley.com/en-us/Organic+Reactions,+Volume+108-p-9781119832072

76. A. J. Pradhan, D. Lu, L. R. Parisi, S. Shen, I. A. Berhane, S. L. Galster, K. Bynum, V. Monje-Galvan, O. Gokcumen, S. R. Chemler, J. Qu, J. G. Kay, G. E. Atilla-Gokcumen* ( 2021 ), “Protein Acylation by Saturated Very Long Chain Fatty Acids and Endocytosis are Involved in Necroptosis,” Cell Chem. Biol ., 28, 1298. https://pubmed.ncbi.nlm.nih.gov/33848465/

75. A. S. Burde, S. D. Karyakarte,E. D. Sylvester, S. R. Chemler* ( 2021 ), “Copper-Catalyzed Enantioselective Synthesis of Bridged Bicyclic Ketals from 1,1-Disubstituted-4-methylene-1,6-hexanediols and Related Alkenols,” Chem. Commun ., 57, 105-108. https://pubs.rsc.org/en/content/articlelanding/2021/cc/d0cc06404a

74. J. J. Kennedy-Ellis, E. D. Boldt, S. R. Chemler* ( 2020 ), “Synthesis of Benzylureas and Related Amine Derivatives via Copper-catalyzed Three-component Carboamination of Styrenes,” Org. Lett ., 22, 8365-8369. https://pubmed.ncbi.nlm.nih.gov/33074005/

73. T. Wdowik, S. Galster, R. L. de Carmo, S. R. Chemler* ( 2020 ), “Enantioselective, Aerobic Copper-Catalyzed Oxidative Cyclization of Alkenols and N-(4-Pentenyl)arylsulfonamides: Synthesis of Fused Ring and Spirocyclic Saturated Heterocycles,” ACS Catalysis , 10, 8535. https://pubs.acs.org/doi/abs/10.1021/acscatal.0c02607

72. D. Chen, I. A. Berhane, S. R. Chemler* ( 2020 ), “Copper-Catalyzed Enantioselective Hydroalkoxylation of Alkenols for the Synthesis of Cyclic Ethers,” Org. Lett. , 22, 7409-7414. Selected for October 2020 Issue Cover. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.0c01691

71. L. R. Parisi, S. Sowlati-Hashjin, I. A. Berhane, S. L. Galster, K. A. Carter, J. F. Lovell, S. R. Chemler, M. Karttunen, G. E. Atilla-Gokcumen* ( 2019 ) “Membrane Disruption by Very Long Chain Fatty Acids During Necroptosis,” ACS Chem. Biol. , 14, 2286-2294.

70. J. M. Shikora, C. Um, Z. M. Khoder, S. R. Chemler* ( 2019 ) “Saturated Oxygen and Nitrogen Heterocycles via Oxidative Coupling of Alkyltrifluoroborates with Alkenols, Alkenoic Acids and Protected Alkenylamines,” Chem. Sci. , 10 , 9265-9269. https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc02835h

69. D. Chen, S. R. Chemler* ( 2018 ), Synthesis of Phthalans Via Copper-Catalyzed Enantioselective Cyclization/Carboetherification of 2-Vinylbenzyl Alcohols,” 20 , 6453-6456.

68. S. D. Karyakarte, C. Um, I. A. Berhane, S. R. Chemler* ( 2018 ), Synthesis of Spirocyclic Ethers by Enantioselective Copper-Catalyzed Carboetherification of Alkenols, Angew. Chem. Int. Ed ., 57 , 12921-12924. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201808554

67. J. M. Shikora, S. R. Chemler* ( 2018 ), Synthesis of Benzylamines via Copper-Catalyzed Enantioselective Aza-Friedel-Crafts Addition of Phenols to N-Sulfonyl Aldimines, Org. Lett . 20, 2133-2137.

66. T. Wdowik, S. R. Chemler* ( 2017 ), Direct Synthesis of 2-Formylpyrrolidines, 2-Pyrrolidinones and 2-Dihydrofuranones Via Aerobic Copper-Catalyzed Aminooxygenation and Dioxygenation of 4-Pentenylsulfonamides and 4-Pentenylalcohols, J. Am. Chem. Soc. 139, 9515-9518. https://pubs.acs.org/doi/10.1021/jacs.7b05680

65. Z. M. Khoder, C. E. Wong, S. R. Chemler* ( 2017 ), Stereoselective Synthesis of Isoxazolidinones Via Copper-Catalyzed Alkene Diamination, ACS Catalysis 7, 4775-4779.

64. S. R. Chemler,* S. D. Karyakarte, Z. M. Khoder ( 2017 ) “Stereoselective and Regioselective Synthesis of Heterocycles Via Copper-Catalyzed Additions of Amine Derivatives and Alcohols to Alkenes,” J. Org. Chem. , 82, 11311-11666.  (invited Perspective, Cover of Issue, Nov. 3, dedicated to this review)

63.       S. R. Chemler* and T. Wdowik ( 2017 ), “Aminohydroxylation and Aminooxygenation of Alkenes,” Chap. 5.3 in Catalytic Oxidation in Organic Synthesis, Vol. 25, Science of Synthesis, K. Muniz, ed., 1, 343-388.

62. C. Um, S. R. Chemler* ( 2016 ), Synthesis of 2-Aryl and 2-Vinylpyrrolidines Via Copper-Catalyzed Coupling of Styrenes and Dienes with Potassium beta-Aminoethyl Trifluoroborates, Org. Lett . 18, 2515-2518.

61. B. J. Casavant, Z. M. Khoder, I. A. Berhane, S. R. Chemler* ( 2015 ), Copper(II) Promoted Cyclization/Difunctionalization of Allenols and Allenylsulfonamides: Synthesis of Heterocycle Functionalized Vinyl Carboxylates, Org. Lett . 17, 5958-5961.

60. S. Karyakarte, F. C. Sequeira, G. H. Zibreg, G. Huang, J. P. Matthew, M. M. M. Ferreira and S. R. Chemler* ( 2015 ), Copper-promoted synthesis of 1,4-benzodiazepinones via alkene diamination, Tetrahedron Lett ., 56, 3686-3689. (Invited for memorial issue for Harry Wasserman.)

59. T. W. Liwosz, S. R. Chemler*, ( 2015 ) Copper-Catalyzed Synthesis of N -Aryl and N -Sulfonyl Indoles from 2-Vinylanilines with O 2 as Terminal Oxidant and TEMPO as Co-Catalyst, Synlett , 26, 335-339. (Invited for cluster issue on earth abundant metals in catalysis.)

58. S. R. Chemler ( 2015 ) “Copper Catalysis in Organic Synthesis,” Beilstein J. Org. Chem . 11 , 2252-2253.

57. B. J. Casavant, A. S. Hosseini, S. R. Chemler* ( 2014 ), 6-Azabicyclo[3.2.1]octanes Via Copper-Catalyzed Enantioselective Alkene Carboamination, Adv. Syn. Cat ., 356 , 2697.

56. M. T. Bovino, T. W. Liwosz, N. E. Kendel, Y. Miller, N. Tyminska, E. Zurek,* S. R. Chemler,* ( 2014 ) Enantioselective Copper-Catalyzed Carboetherification of Unactivated Alkenes, Angew. Chem. Int. Ed. , 53 , 6383.

55. B. W. Turnpenny and S. R. Chemler* ( 2014 ), “Copper-Catalyzed Alkene Diamination: Synthesis of Chiral 2-Aminomethylindolines and Pyrrolidines,” Chem. Sci . 5 , 1786.

54. L. Belding, S. R. Chemler, T. Dudding* ( 2013 ), “A Computational Study of the Copper(II)-Catalyzed Enantioselective Intramolecular Aminooxygenation of Alkenes,” J. Org. Chem. 78 , 10288.

53. T. W. Liwosz and S. R. Chemler* ( 2013 ), “Copper-Catalyzed Oxidative Amination and Allylic Amination of Alkenes,” Chemistry: A European Journal (Wiley-Blackwell), 19, 12771.

52. T. W. Liwosz and S. R. Chemler* ( 2013 ), “Copper-Catalyzed Oxidative Heck

Reactions between Alkyltrifluoroborates and Vinyl Arenes,” Org. Lett. (ACS), 15 , 3034-3037. http://pubs.acs.org/doi/pdf/10.1021/ol401220b

51.  M. C. Paderes, J. B. Keister,* S. R. Chemler* ( 2013 ), “Mechanistic Analysis and Optimization of the Copper-Catalyzed Enantioselective Intramolecular Alkene Aminooxygenation,” 78 , 506.

50.  S. R. Chemler* and M. T. Bovino ( 2013 ) “Catalytic Aminohalogenation of Alkenes and Alkynes,” ACS Catalysis , 3 , 1076.

49.  S. R. Chemler ( 2013 ) “Copper’s Contribution to Amination Catalysis,” Science , 341 , 624-626.

48.       S. R. Chemler* and D. A. Copeland ( 2013 ), “Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions,” Top. Heterocycl. Chem. Springer-Verlag Berlin Heidelberg J. P. Wolfe, Ed.

47. B. W. Turnpenny, K. L. Hyman, S. R. Chemler* ( 2012 ), “Chiral Indoline Synthesis Via Enantioselective Intramolecular Copper-Catalyzed Alkene Hydroamination,” Organometallics , 31 , 7819.  https://pubs.acs.org/doi/10.1021/om300744m

46.  F. C. Sequiera, S. R. Chemler* ( 2012 ), “Stereoselective Synthesis of Morpholines Via Copper(II)-Promoted Alkene Oxyamination,” Org. Lett . 14, 4482-4485.

45.  S. Karyakarte, T. P. Smith, S. R. Chemler* ( 2012 ), “Stereoselective Isoxazolidine Formation via Copper-Catalyzed Alkene Aminooxygenation,” J. Org. Chem ., 17, 7755-7760.

44. Y. Miller, L. Miao, A. Hosseini, S. R. Chemler* ( 2012 ) “Copper-Catalyzed Intramolecular Alkene Carboetherification: Synthesis of Fused-Ring and Bridged-Ring Tetrahydrofurans,” J. Am. Chem. Soc . 134 , 12149-12156.

43. F. C. Sequeira, M. T. Bovino, A. J. Chipre, S. R. Chemler* ( 2012 ) “Multigram Synthesis of a Chiral Substituted Indoline via Copper-Catalyzed Alkene Aminooxygenation,” Synthesis, 44 , 1481-1484 (invited special topic).

42. M. T. Bovino and S. R. Chemler* ( 2012 ), “Catalytic Enantioselective Alkene Aminohalogenation / Cyclization Involving Atom Transfer, ” Angew. Chem. Int. Ed. 51 , 3923-3927.

41.  T. W. Liwosz, S. R. Chemler* ( 2012 ), “Copper-Catalyzed Enantioselective Intramolecular Alkene Amination / Intermolecular Heck-type Coupling Cascade,” J. Am. Chem. Soc. 134 , 2020-2023.

40.  M. C. Paderes, L. Belding, B. Fanovic, T. Dudding,* J. B. Keister* and S. R. Chemler* ( 2012 ), “Evidence for Alkene Cis-Aminocupration, an Aminooxygenation Case Study: Kinetics, EPR Spectroscopy and DFT Calculations,” Chem. Eur. J . 18 , 1711-1726.

39.  S. R. Chemler* and B. J. Casavant ( 2012 ), “Copper(II) 2-ethylhexanoate,” contribution to The (electronic) Encyclopedia of Reagents for Organic Synthesis (e-EROS), A. B. Charette, editor.

38.  M. C. Paderes and S. R. Chemler * ( 2011 ), “Stereoselective Copper-Catalyzed Intramolecular Alkene Aminooxygenation: Effect of Substrate and Ligand Structure on Selectivity,”  Eur. J. Org. Chem. Special edition, 3679-3684 .

37.   S. R. Chemler (2011) “Evolution of copper(II) as a new alkene amination promoter and catalyst,” invited review, J. Organomet. Chem. 696, 150-158.

36.    S. R. Chemler (2011) , “Stereoselective nitrogen heterocycle synthesis mediated by chiral metal catalysts,” Chap. 16 in Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications, Wiley-VCH, M. Gruttadauria, Ed.

35.  L. Miao, I. Haque, M. R. Manzoni, W. S. Tham and S. R. Chemler* ( 2010 ), “Diastereo- and   

Enantioselective Copper-Catalyzed Intramolecular Carboamination of Alkenes for the Synthesis of Hexahydro-1 H -benz[ f ]indoles,” Org. Lett . 12, 4739-4741.

34. F. C. Sequiera. B. W. Turnpenny and S. R. Chemler * ( 2010 ), “Copper(II)-Promoted and Catalyzed Intermolecular Diamination of Alkenes,” Angew. Chem. Int. Ed. , 49, 6365-6368.

33. M. Paderes and S. R. Chemler * ( 2009 ), “Diastereoselective Pyrrolidine Synthesis via Copper Promoted Intramolecular Aminooxygenation of Alkenes; Formal Synthesis of (+)-Monomurine,” Org. Lett. 11, 1915-1918.

32. E. S. Sherman and S. R. Chemler* ( 2009 ), “Copper(II)-Catalyzed Aminooxygenation and Carboamination of N-Aryl-2-allylanilines,” Adv. Synth. Catal. 351, 467-471.

31.    S. R. Chemler, ( 2009 ) “Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy,” invited review, Current Bioactive Compounds , 5, 2-19.

30.    S. R. Chemler (2009) “The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocycles,” invited review, Organic and Biomolecular Chemistry, 7 , 3009-3019.

29.    S. R. Chemler ( 2009 ), “Product Class Amido Derivatives of Sulfanediol,” Science of Synthesis, Vol. 40, 40.9. E. Schaumann, D. Enders, Eds.

28.    S. R. Chemler ( 2009 ), “Product Class Amido Derivatives of Sulfurous Acid,” Science of Synthesis, Vol. 40, 40.10, E. Schaumann, D. Enders, Eds.

27.    E. S. Sherman, S. R. Chemler* ( 2009 ), “Product Class N-Alkylsulfamic Acids and Derivatives,” Science of Synthesis, Vol. 40, 40.11, E. Schaumann, D. Enders, Eds.

26.    S. R. Chemler (2009) , “Roush Allylboronation,” in Name Reactions for Homologations , J. Li and E. J. Corey, Eds., pps. 613-640 .

25. J. Ni; T. Mai; S.-T. Pang, I. Haque, K. Huang, M. A. DiMaggio; S. Xie; N. S. James; D. Kasi; S. R. Chemler * and S. Yeh,* ( 2009 ) “Novel Vitamin E Ether Analog Inhibits Prostate Cancer Cell Growth In Vitro and In Vivo.” Clin. Cancer Res. 15, 898-906.

24.   P. H. Fuller, J.-W. Kim, S. R. Chemler* ( 2008 ) “Copper catalyzed enantioselective intramolecular aminooxygenation of alkenes,” J. Am. Chem. Soc . 130, 17638-17639.

23.  W. Zeng., S. R. Chemler* ( 2008 ) “Total Synthesis of (S)-(+)-Tylophorine Via Enantioselective Intramolecular Alkene Carboamination.” J. Org. Chem. 73, 6045-6047.

22.    S. R. Chemler ( 2008 ) “Isopropenyllithium,” contribution to The Encyclopedia of Reagents for Organic Synthesis (EROS), L. Paquette, editor.

21.   P. H. Fuller and S. R. Chemler* ( 2007 ) “Copper(II) Carboxylate Promoted Intramolecular

    Carboamination of Alkenes for the Synthesis of Polycyclic Lactams,” Org. Lett . 9, 5477-5480.**

20.   W. Zeng and S. R. Chemler* ( 2007 ) “Copper(II)-Catalyzed Enantioselective Intramolecular Carboamination of Alkenes,” J. Am. Chem. Soc. 129, 12948-12949.**

19.   T. P. Zabawa, S. R. Chemler * (2007) “Copper(II) Carboxylate Promoted Intramolecular Diamination of Unactivated Alkenes for the Synthesis of Cyclic Vicinal Diamines: Diastereoselectivity and Expanded Substrate Scope” Org. Lett. 9. 2035-2038.

18.   E. S. Sherman; P. H. Fuller; D. Kasi; S. R. Chemler,* ( 2007 ), “Pyrrolidine and Piperidine Formation Via Copper(II) Carboxylate Promoted Intramolecular Carboamination of Unactivated Olefins: Diastereoselectivity and Mechanism,” J. Org. Chem. 72, 3896-3905.

17.   E. Cheng, J. Ni, Y. Yin, C. C. Lin, P. Chang, N. S. James, S. R. Chemler, S. Yeh* ( 2007 ), “alpha-Vitamin E Derivative, RRR-alpha-Tocopheryloxybutyric Acid Inhibits the Proliferation of Prostate Cancer Cells,” Asian J. Andrology , 9 . 31.

16.    S. R. Chemler* and P. H. Fuller ( 2007 ) “Heterocycle Synthesis by Copper Facilitated Additions of Amines to Alkenes, Alkynes and Arenes,” invited review, Chemical Society Reviews , 36 , 1153-1160.

15.   S. R. Chemler and T. P. Zabawa ( 2006 ) “Three Carbon-Heteroatom Bonds: Alpha-Heteroatom Substituted Alkanoic Acids and their Ester Derivatives,” Science of Synthesis, Vol. 20a, E. Jacobsen, Ed. Section 20.2.8, “Product Subclass 8: 2-Heteroatom-Substituted Alkanoic Acids,” 483-505.

14.    S. R. Chemler and T. P. Zabawa ( 2006 ) “Three Carbon-Heteroatom Bonds: Alpha-Heteroatom Substituted Alkanoic Acids and their Ester Derivatives,” Science of Synthesis, Vol. 20b, E. Jacobsen, Ed. Section 20.5.11, “Product Subclass 11: 2-Heteroatom-Substituted Alkanoic Acid Esters,” 1203-1242.

13.   T. P. Zabawa, D. Kasi, S. R. Chemler, *  (2005 ) “Copper(II) Acetate Promoted Intramolecular Diamination of Unactivated Olefins,” J. Am. Chem. Soc., 127, 11250-11251 .

12.   Y. Wu, K. Zu, J. Ni, S. Yeh, D. Kasi, N. S. James, S. R. Chemler and C. Ip* ( 2004 ).  “Cellular and Molecular Effects of alpha-Tocopheryloxybutyrate: Lessons for the Design of Vitamin E Analog for Cancer Prevention” Anticancer Research, 24 , 3795-3802.

11.   M. R. Manzoni, T. P. Zabawa, D. Kasi and S. R. Chemler * ( 2004 ). “Palladium(II) Catalyzed Intramolecular Aminobromination and Aminochlorination of Olefins,” Organometallics , 5618-5621.

10.   E. S. Sherman, S. R. Chemler,* T. B. Tan and O. Gerlits ( 2004 ). “Copper(II) Acetate Promoted Oxidative Cyclization of Arylsulfonyl-o-allylanilines,” Org. Lett. 10 , 1573-1575.

Prior to UB (PhD and Postdoc)

9.     S. R. Chemler, W. R. Roush* ( 2003 ). “Stereochemistry of the Allylation and Crotylation Reactions of alpha-Methyl-beta-Hydroxy Aldehydes with Allyl- and Crotyltrifluorosilanes.  Synthesis of Anti, Anti-Dipropionate Stereotriads and Stereodivergent Pathways for the Reactions of 2,3-Anti and 2,3-Syn alpha-Methyl-beta-Hydroxy Aldehydes,” J. Org. Chem . 68 , 1319-1333.

8.      S. R. Chemler, D. Trauner and S. J. Danishefsky* ( 2001 ) “The B -Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study and Applications in Natural Product Synthesis,” Angew. Chem. Int. Ed., 40 , 4544-4568.

7.      S. R. Chemler and W. R. Roush ( 2000 ) “Recent Applications of the Allylation Reaction to the Synthesis of Natural Products” Chap. 11 in Modern Carbonyl Chemistry , J. Otera, Ed., Wiley-VCH: Weinheim.

6.     S. R. Chemler, U. Iserloh and S. J. Danishefsky* ( 2001 ). “Toward an Enantioselective Synthesis of Phomactin A: Construction of the Oxadecalin Core via a Highly Stereoselective Diels-Alder Reaction,” Org. Lett . 3 , 2949-2951.

5.     S. R. Chemler and S. J. Danishefsky* ( 2000 ). “Transannular Macrocyclization via Intramolecular B -Alkyl Suzuki Reaction,” Org. Lett. 2 , 2695-2698.

4.     S. R. Chemler, D. S. Coffey and W. R. Roush* ( 1999 ). “An Improved Synthesis of the ( E,Z )-Dienoate Precursor of (+)-Damavaricin D Via a Vinylogous Horner-Wadsworth-Emmons Reaction,” Tetrahedron Lett. 40 , 1.

3.     S. R. Chemler and W. R. Roush* ( 1999 ). “Stereochemically Divergent Pathways for the Allylation and Crotylation Reactions of Anti- and Syn-beta-Hydroxy-alpha-Methyl Aldehydes with Allyl- and Crotyltrifluorosilanes,” Tetrahedron Lett., 40 , 4643-4647.

2.     K. A. Scheidt, H. Chen, B. C. Follows, S. R. Chemler, D. S. Coffey and W. R. Roush* ( 1998 ).  “Tris(dimethylamino)sulfonium Difluorotrimethylsilicate, a Mild Reagent for the Removal of Silicon,” J. Org. Chem. 19 , 6436-6437.

1.     S. R. Chemler and W. R. Roush* ( 1998 ). “Concerning the Synthesis of the Elusive Anti,Anti-Dipropionate Stereotriad via the Crotylation of alpha-Methyl-beta-Hydroxy Aldehydes with ( Z )-Crotyltrifluorosilane.  Application to the Synthesis of the C(7)-C(16) Segment of Zincophorin,” J. Org. Chem. 63 , 3800-3801.

Department of Chemistry

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• 11/28/23 Chemistry at UB
• 11/28/23 Undergraduate Overview
• 11/28/23 Graduate Overview

Meet Our Faculty

Graduate Research Highlights

My research is centered around developing stable solid electrolyte interphase (SEI) layers for NaK alloy batteries. To achieve this, we use in situ characterization techniques to determine the composition of the SEI layer. Additionally, I am involved in studying the electro-Fenton process for generating hydroxyl radicals which can help degrade Perfluoroalkyl substances in water.

My research focuses on understanding the molecular factors that enhance a compounds activity against a protein in drug discovery and development. Specifically, I develop and study inhibitors of NADPH Oxidases and Epidermal growth factor receptor, to understand the structural features that enable the development of potent inhibitors against these enzymes for the treatment of several diseases.

My research focuses on synthesis of bench stable manganese(III) precursor complexes for exploring the chemistry of high valent manganese. I investigate the coordination chemistry and reactivity of these complexes in an effort to demonstrate their utility.

My research primarily focuses on the analysis of emerging contaminants and other biomarkers for assessing community health through wastewater-based epidemiology. In particular, the development of effective sample preparation techniques for the analysis of complex aqueous environmental matrices using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high-resolution mass spectrometry (HRMS) methods. 

Broadly, our research examines the surfaces and interfaces of waste plastic chemistry using visible, mid-, and near-infrared spectroscopy. We seek to gain a more fundamental understanding of these “messy” materials to advance autonomous recycling technologies and enhance the polymer circular economy.

I am interested in researching the development and application of bioorthogonal reagents, particularly hydrazonyl sultones, which are stable tautomers of nitrile imines. My focus is on using these reagents for selective protein modifications in both solutions and live cells to answer biological questions.

My research primarily discusses the synthesis and characterization of highly reactive novel zinc(II) and manganese(II) complexes towards catalytic hydrogenation of selected polar substrates. Currently, I am working on exploring the coordination chemistry of the recently discovered bench-stable Mn(III) trichlorido complex in our lab alongside stabilizing highly reactive Zn(II) and Ti(IV) centers with organophosphorus compounds.

My research focuses on the development of hydrolytically stable phenylenediamine-modified silica particles for chromatographic applications. Another research focus is the study of diarylethene-based photoswitches using liquid and supercritical fluid chromatography.

My research revolves around the role lipids play during necroptosis, particularly investigating the causes of lipid accumulation observed during necroptosis.

My research interests are designing, synthesizing, and characterizing polynuclear metalloporphyrin or porphyrin derivative complexes and using these complexes for electrocatalysts for small molecule activation.

My research focuses on the design and development of novel iron (III) macrocyclic compounds for use at T1 MRI contrast agents. Currently, I am focused on studying how changing a single coordinating pendant effects the relaxivity of these compounds by using variable field strength NMR and MRI. 

Within the Gong lab we’re interested in studying new supramolecular systems. Within this area we have developed novel aromatic oligoamide foldamers and macrocycles for applications in catalysis, transmembrane transport, and molecular recognition. 

My research focuses on the detection of veterinary antimicrobials and their transformation products in agricultural matrices. Our studies primarily involve the development and application of liquid chromatography tandem mass spectrometry (LC-MS/MS) and high-resolution mass spectrometry (HRMS) methods for the analyses of swine manure and simulated agricultural runoff, to better understand the fate of antimicrobials in the agricultural environment.

My current research mainly focuses on batteries and electrocatalysis. I’m also looking forward to incorporating in-situ characterization methods into regular electrochemical testing to better understand the underlying mechanism and improve existing system designs.

Nonadiabatic molecular dynamics can provide atomistic insights into photochemical and photophysical properties of solar energy and photocatalytic materials but modeling such processes for realistic nanoscale materials, comparable to experimental studies, is computationally expensive. In our recent publication, we implemented an optimized and parallelized code to study excited states dynamics in large nanoscale and periodic systems with thousands of atoms such as silicon quantum dots and 2D graphitic carbon nitride.

My research centers around the utilization of crystal engineering to transform the notorious active pharmaceutical ingredient nicotine into a safer, more stable and tunable solid-state material through the use of US FDA generally recognized as safe (GRAS) substances. By crystallizing liquid nicotine with GRAS listed components and engineering these materials to safely degrade, we are able to eliminate the current pitfalls associated with nicotine products and deliver a safer and tunable material to the end user.

My research primary focused on the investigation of dinuclear Mn(I) complexes, their interaction with molecular hydrogen, and their development as hydrogenation catalysts. We have synthesized new dinuclear Mn(I) complexes with bridging phosphides and/or hydrides and conducted detailed mechanistic and kinetic investigations of their ability to split molecular hydrogen and catalytically reduce alkynes to trans -alkenes.

My research deals with developing synthetic strategies towards chiral saturated oxygen heterocycles using copper catalysis. Our developed methodologies allow for the expedient synthesis of biologically relevant compounds.

Rebecca’s current research involves developing new techniques for suspect screening and non-target analysis for contaminants of emerging concern, specifically focusing on per- and polyfluoroalkyl substances (PFAS). This analysis is primarily done in wastewater and biosolids in order to understand mass flows of PFAS within treatment facilities, as well as identification and quantification of unknown PFAS contaminants.

My research focuses on theoretical predications of crystal structures especially hydrides under high pressure. I also study the electronic properties and predict the superconducting properties of new compounds.

My research focuses on synthesis and characterization of iron and manganese coordination complexes towards catalyst design. Exploring the coordination chemistry of these metal complexes allows us to fine tune their reactivities to develop greener chemical reagents that can perform novel chemical transformations.

My research focuses on characterization of photoinduced interfacial charge-transfer dynamics within dual-quantum dot (QD) heterostructures, both colloidal and surface-immobilized, working towards applications in redox photocatalysis. Currently, I am working on characterizing photoelectrochemical hydrogen evolution within Sb 2 VO 5 /QD heterostructures as possible next generation photocatalysts for solar fuel production.

I am currently working on heterogeneous electrocatalysis to oxidize ethane into acetate. In the future, I would like to try to electrochemically degrade microplastics for environmental remediation applications.

My research focuses on the synthesis and coordination chemistry of novel organomanganese and organoruthenium complexes towards catalysis. Our work seeks to probe the structures of intermediates that are typically implicated in catalysis.

My research consisted of surface analytical chemistry focused on PFASs detection, qualification, and quantification on various polymers, including microplastic pieces collected from the Great Lakes.

I use nonlinear second-order vibrational sum frequency generation spectroscopy along with complimentary techniques in order to elucidate the molecular organization and inter- and intramolecular interactions of neat liquids as well as binary solvent mixtures at hydrophilic and hydrophobic solid/liquid interfaces.

My research focuses on understanding the process of necroptosis, a type of controlled necrosis in terms of its execution, regulation and cellular fate by using different molecular biology techniques.

I have worked on the development of tools that allow us to calculate vibrationally resolved spectra in the near-infrared region for metal complexes with Oh and D­ 3 point group symmetry.

I study a novel atmospheric pressure glow discharge that is used for atomic spectroscopy.

My research primarily concerned developing direct methods of analysis and ambient ionization platforms utilizing Fourier transform mass spectrometry. Applications were broad in the fields of –omics studies, ranging from the profiling of abiotic stress responses of soybean to the investigation of animal models of disease by mass spectrometry imaging.

My research focuses in studying the potential applications and capabilities of microwave heating in diverse analytical applications. By implementing systems specifically designed for focused-microwave fields we can greatly accelerate biochemical reactions and, also, expand the capabilities of ionization in mass spectrometry.

My research focuses mainly on utilizing copper-based catalysts towards the development of enantioselective alkene difunctionalisation reactions involving radical group transfer. The ability to combine enantioselectivity with radical group transfers makes this chemistry unique and exceedingly useful for the synthesis of biologically important molecules.

My research centers around the synthesis, characterization, and reactivity of multinuclear catalysts, specifically cofacial porphyrin prisms. We use coordination-driven self-assembly to furnish complex molecular architectures through straightforward syntheses.

I study non-adiabatic quantum dynamics and develop code for Libra, and open source quantum dynamics software package.

My research involves copper-catalysed difunctionalisation of alkenes, primarily using alkyl trifluoroborates as a radical source. I am currently working on enantioselective carboaminations and carboetherifications.

My research focuses on developing methods to analyze persistent organic pollutants in various environmental matrices. The optimized methods are then applied to measure chemical exposures in different populations such as humans and wildlife.

My research is focused on novel synthetic approaches to organic/inorganic hybrid materials using combined principles of polymer chemistry and coordination-driven self-assembly. The goal of this work is to gain a better understanding of interactions at the polymer/inorganic interface, and to obtain highly porous, mechanically robust functional materials that can ultimately be used for industrial applications such as CO 2 capture.

My research focuses on designing, synthesizing and the characterization of Fe(III) macrocyclic complexes as T1 MRI contrast agents. I utilize NMR and MRI methods for characterization of complexes  in vitro  and in mice.

My research focuses on elucidating lipid involvement in cellular senescence. An improved understanding of lipid function has the potential to introduce druggable lipid-related protein targets, paving the way for new therapeutic strategies.

My research focuses on the development of mass spectrometry based analytical methods than can facilitate identification, structural elucidation and trace quantification of micropollutants in environmental samples.

My research revolves around the synthesis, functionalization and application of 1,3-dienes to ultimately be applied towards the total synthesis of nannocystin A. My recent publication is an example of functionalizing 1,3 dienes that will be utilized en route to my final goal.

My current research involves creating core/shell nanoparticle architectures and enhancing the visible and NIR emission for in vivo imaging and sensing.

My research is about looking at the global occurrence of micropollutants such as pharmaceuticals, pesticides, and other chemicals of emerging concern in the aquatic environment using liquid chromatography mass spectrometry. We collaborate with engineers and other scientists to study the development of environmental antimicrobial resistance, pharmaceutical removal efficiencies of wastewater treatment plants, and the eco-toxicological effects of these compounds on aquatic life.

Labeling mammalian and fungal cells with MRI contrast agents to study the behavior of contrast agents due to compartmentalization in the cells for potential applications in cell therapy imaging and infection diagnosis.

"My research was based in the discovery and development of organic methodologies which can be applied in the synthesis of biologically active molecules."

I am currently preparing, developing novel titration methods for, and assessing the reactivity of solid-supported isocyanide-based metal scavengers for rapid removal of transition metal complexes from solution. These materials are useful in the lab for both arresting transition metal catalysts and removing the toxic – and sometimes detrimentally reactive – metal complexes from solution via filtration.

As a member of the Benedict group I am designing and synthesizing novel stimuli responsive dynamic materials which we can monitor using in situ single crystal X-ray diffraction. Currently I have been exploring colorimetric techniques for testing sonicator homogeneity using imine sonochemistry.

"My research in the Wood lab focuses on the utilization of high resolution mass spectrometry to investigate small molecules in their roles in disease states. Although the majority of my work focuses in metabolomics, investigating stercobilin as a putative biomarker for autism, I have recently started work in the fields of lipidomics and proteomics."

"My research focus is on integrating theory and experiment to the design, synthesis, and characterization of semiconductor heterostructures with programmable light harvesting and charge transfer for photocatalysis."

"My research focuses on the fundamental photophysics of multi-chromophore systems attained using coordination-driven self-assembly, focusing on transition metal chromophores as structural elements of the assembly. By using these supramolecular metallocycles and cages, we can manipulate photophysical properties by the introduction of multiple, communicative excited states as well as changing both radiative and non-radiative rate constants."

"My research is on the functional characterization of lipids during apoptosis. I am particularly interested in how lipid droplet and its lipid components, such as triacylglycerols, are involved in this process."

"My research in Prof. Eva Zurek’s group mainly focuses on predicting the structures of materials at high pressures using the open-source evolutionary algorithm XTALOPT coupled with density functional theory (DFT) calculations. My interests include superconductors, photovoltaic materials, as well as compounds of geologic relevance."

"My research focuses on the synthesis and reactivity of novel organometallic and inorganic compounds with manganese metal centers."

"Understanding the self-assembly of surfactants on the surface of single wall carbon nanotubes using an interfacial sensitive technique Sum frequency generation (SFG), by studying the effects of the nanotube’s diameter, surfactant concentration (SDS) and the counterions (Na + , Ca +2 )."

"My research revolves around exploring the host-guest chemistry of supramolecular coordination compounds."

"My research goals include studying the mechanism and rationally design an inhibitor for an enzyme that confers pathogenicity to  Mycobacterium tuberculosis ."

"As a N.Y. Sea Grant Scholar, my current research uses liquid chromatography tandem mass spectrometry to investigate the removal efficiency of conventional and advanced wastewater treatment systems for a variety of pharmaceuticals."

"We have developed a methodology for treating quantum nuclear effects within the framework of classical mechanics which allows for their inclusion in molecular dynamics simulations at a fraction of the cost."

"My research focuses on understanding the roles of specific lipids during necroptosis, a unique type of programmed cell death which has been associated with pathologies including neurodegenerative diseases, ischaemia-reperfusion injuries, and cancer."

"My thesis research project focuses on developing new charge carriers for redox flow batteries (RFBs) using molecular-level design principles guided by electrochemical analysis to address stability, solubility and energy density."

"My research focuses on exploring oxygen as a reagent and/or oxidant for copper-catalyzed reactions that are useful for the synthesis of nitrogen and oxygen based heterocycles."

"My graduate research is primarily focused on the synthesis of reactive bottlebrush copolymers and their use in forming macromolecular architectures such as star-brush polymers, network structures, hydrogels, and nanogels."

"My research interest is on the impact of nanoparticles on plant systems and cell lines. I look for metabolomic changes in these systems using liquid chromatography with quadrupole time-of-flight mass spectrometry."

"My research focuses on developing organomanganese catalysts for photochemical water splitting. Our long-term goal is to achieve photocatalytic conversion of water to H 2  and O 2  using earth-abundant single-site organometallic complexes."

Alex’s research focuses on understanding the influence of solvent such as water on the structural and nuclear magnetic resonance properties of heavy element complexes. 

"My research focuses on an alkene difunctionalization reaction using a copper(II) salt as an earth abundant and relatively less toxic metal catalyst." 

"My project focuses on self-assembled cofacial catalysts for the oxygen reduction reaction." 

"The research I do focuses on the synthesis and analysis of paramagnetic transition metal complexes made of macrocyclic ligands with pendent arm to coordinate to the metal ion." 

"My research is focused on better understanding the chemistry involved in molecules being adsorbed to metallic surfaces and what properties exhibited by such systems are useful." 

"My research focuses on the development and evaluation of new stationary phases for liquid and supercritical fluid chromatography." 

"My research focuses on the functional involvement of lipids in different cellular processes, including senescence, using global LC-MS-based lipidomics." 

"My research focuses on designing modified microarrays on porous silicon platforms which can be used for a host of applications including lab-on-chip devices and label-free multi-analyte chemical sensors." 

"My research focuses on the synthesis and mechanistic investigation of methylene-free enyne metathesis." 

"I study photo-induced electron transfer in covalently linked quantum dots donor – metal oxide acceptor assemblies relevant to solar energy conversion by using steady state and time resolved emission spectroscopy." 

"My research is focused on using liquid chromatography mass spectrometry to analyze the metabolites produced by a non-model green microalgae,  Ettlia oleoabundans ." 

"My research is focused on the development of antifouling and fouling-release hull coatings for the United States Navy." 

"The core of my research is to develop novel copper-catalyzed oxidation of potassium alkyl trifluoroborate salt to generate radical, which is used to functionalize alkenes." 

"My research involved designing photo-responsive multi-analyte chemical sensors on porous silicon platforms through surface functionalization and various printing methods." 

"My research deals with the synthesis of linear block copolymers that self-assemble to form ordered periodic nanostructures." 

"Our goal is to synthesize red-shifted azobenzene amino acids that can be incorporated into protein using amber codon suppression technique, with the aim of achieving spatiotemporal control using visible light." 

"My research is focused on preparation and separation of carbon nanomaterial by high performance liquid chromatography (HPLC) and the development of novel diamond-based stationary phases for separation science." 

Josh uses mass spectrometry and surface analytical techniques as a method for investigating environmental issues of salient public concern.

"As a member of the Benedict Lab I am designing and synthesizing photochromic metal-organic frameworks."

"The research that I do in the Zurek lab comprises the use of evolutionary algorithms and Density Functional Theory to find stable crystal structures at extreme pressures."

"I am working on a project to optimize the properties of anti-cancer drug candidates."

"The main focus of my research was to develop very unique Zn(II)-macrocyclic complexes for the recognition of thymine in non-canonical DNA secondary structures, such as G-quadruplexes and bulges."

"My research focuses on the synthesis of colloidal quantum dots and surface functionalization to build quantum dot-molecule-semiconductor interfaces that promote photoinduced charge-transfer."

"The primary goal of my research is to study various properties of functional materials by colocalized Raman and atomic force microscopy."

"My research primarily focused on the synthesis of chalcogenopyrylium dyes that display a high affinity for the surface of gold nanoparticles."

"I’m currently studying the diffusion of flame retardants in polymeric fabrics using the TOF-SIMs."

"My research project focused on the investigation of the function of a nonreacting phosphate group in enzymatic catalysis using diverse experimental methods such as organic synthesis, kinetic isotope effect measurements and protein X-ray crystallography."

"My research focuses on the analysis and determination of estrogens and their transformation products in environmental matrices such as animal waste, wastewater and surface water."

"I really enjoy the atmosphere of the graduate program at UB, the sense of camaraderie and that everyone is working for the common goal of furthering scientific knowledge."

• 4/3/24 Prof. Steven Ray helps distribute over 12,000 NSF eclipse glasses to local students and community centers
• 4/2/24 Heppner lab and collaborators publish study that proposes a streamlined approach to drug design
• 4/17/24 Help Chemistry's Matching Challenge This Giving Day!
• 3/28/24 Emanuela Gionfriddo listed among the 2023 Rising Stars in Measurement Science by ACS Measurement Science Au
• 3/6/24 PhD student Mindula Wijayahena wins first place at UB's eighth annual Three Minute Thesis Competition

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Theileriosis in Buffalo: A Case Study

Bovine theileriosis is caused by the protozoan parasite Theileria annulata and Theileria parva and is transmitted through tick Hyalomma and Rhipicephalus, respectively leading to economic losses and causes devastating losses to the livestock worldwide. This paper deals with clinical signs, diagnosis and treatment of theileriosis in buffalo having 4years of age and clinical signs observed were; high fever (106.7oF), anorexia, enlarge lymph nodes, dyspnoea and ocular discharge with pale mucous membrane. The peripheral blood smear confirmed the presence of Koch blue bodies. The animal was treated with a single dose of Buparvaquone, 2.5 mg/kg i.m. along with supportive therapy.

Related Papers

Bachal Bhutto

Comparative Clinical Pathology

Vikrant Sudan

Vivek Kasaralikar

Bovine Theileriosis is a haemoprotozoan disease caused by Theileria spp in cattle lead to huge depreciation in terms of economy of farmer and mainly transmitted by Hyalomma and Rhipicephalus ticks. In the present study a total of ten cases suspected for theileriosis with the clinical signs such as elevated body temperature, enlarged superficial lymphodes, anaemia, tachycardia and presence of ticks over the body were studied. Further they were subjected to haematological examination, thin blood smear examination and further confirmed by PCR assay. The results revealed that, haematological examinations implicated severe anaemia whereas thin blood smear examination showed presence of pleomorphic theilerial organisms in the RBC’s and amplification of expected PCR product of 1098-bp by targeting theileria genus specific primers for the SSU rRNA gene confirming theileriosis in cattle. The affected animals were treated with Inj Buparvaquone @ 3.5 mg/Kg given deep intramuscularly once as an...

Veterinary Parasitology

Salama Osman

Tilahun Bekele

Arthropod transmitted hemoparasitic diseases are economically important vector-borne diseases of tropical and subtropical parts of the world including Ethiopia. Bovine theileriosis is a tick-borne hemoprotozoan disease of cattle caused by several theileria species and among them T. parva, the cause of East Coast fever and T. annulata, the causative agent of tropical theileriosis are the most pathogenic and economically important. The aim of this manuscript is to review currently available articles on the bovine theileriosis with a special attention to its control. Theileria have complex life cycles involving both vertebrate and invertebrate hosts. Tropical theileriosis and East Coast Fever are disease transmitted by Ixodid tick of the genus Hyalomma and Rhipicephalus, respectively. Furthermore, the sporozoites are transmitted to animals in the saliva of the feeding tick. Bovine theileriosis is characterized by high fever, weakness, weight loss, inappropriate appetite, conjunctival p...

Mamohale Chaisi

Journal of entomology and zoology studies

A case of HF cross-bred cattle of seven years old with history of ticks, fever, reduced feed and water intake, bilateral nasal discharge, lacrimation, six months pregnant was presented to VCC Navania. On clinical examination revealed high body temperature, increased respiration, tachycardia with enlarged lymph nodes. It was suspected for Theileriosis and different laboratory diagnoses were performed. Smear was made from peripheral blood sample. On Giemsa staining Koch blue bodies were identified in the lymphocytes. Haematological parameters were done using peripheral blood samples. RBC`s, WBC`s, haemoglobin and packed cell volume found decreased as compared to normal values. The present case report showed that Theileria infection in cattle might be associated with haematological changes and successfully treated with single dose of Inj. Buparvoquone (2.5 mg/kg i.m.) and Inj. Oxytetracycline for next three days along with supportive therapy.

BJSTR Angela Roy

Theileria annulata causes bovine tropical theileriosis, a tick-borne disease with major economic implications in tropical and subtropical areas of the world. The purpose of this study was to use polymerase chain reaction (PCR) to detect theilerosis in Kundhi Buffaloes. Theileriosis is often diagnosed using a blood smear staining technique that is insufficiently sensitive to detect piroplasms in carrier animals. A total of n = 200 samples were taken from sick and apparently healthy Kundhi Buffaloes for this study. Giemsa staining of blood smears revealed 25 samples (12.5%) positive for Theileria piroplasms out of a total of 200 samples. However, PCR-based screening utilizing specific primers from the T. annulata (Tams1) gene’s main merozoitepiroplasm surface antigen sequence discovered 115 samples (57.50%) positive for T. annulata. According to our findings, PCR-based screening is a more sensitive and accurate method for diagnosing tropical theileriosis in Kundhi buffaloes.

International Journal of Current Microbiology and Applied Sciences

Mahendra S I N G H Meel

Theileria diseases are known to cause heavy losses to the livestock industry. Lack of appropriate control strategies for this disease lead to increase in mortality, reduced milk production, lowered animal drought power, ultimately produces constraint to the dairy industry. Theileriosis is a tick-borne disease, caused by Theileria annulata. The vector ticks are of the genus Hyalomma. This case report revealed the successful therapeutic management of theileriosis in Tharparkar calves. Clinical examination of affected calves revealed high fever (104.50 F to 1060F), dullness, anorexia and enlarged lymph nodes. The blood smears examination after staining revealed the presence of Theileria organisms. Buparvaquone along with supportive therapy could cure calves.

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

Ahmed N . F . Neamat-Allah

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Seven UB researchers elected AAAS fellows

Aaas is the world's largest general scientific society; past fellows include thomas edison, w.e.b dubois.

By News Staff

Release Date: April 18, 2024

BUFFALO, N.Y. – Seven University at Buffalo scholars have been elected fellows of the American Association for the Advancement of Science (AAAS), which is the world's largest general scientific society and publisher of the journal Science.

The honor is bestowed annually upon scientists, engineers and innovators who have been recognized for their achievements across disciplines, from research, teaching and technology, to administration in academia, industry and government, to excellence in communicating and interpreting science to the public, according to AAAS.

The new UB fellows include: Sherry Chemler, Jean-Pierre Koenig, Kemper Lewis, Gabriela Popescu, Thomas Russo, Frederick Stoss and Janet Yang.

Sherry Chemler

“For distinguished contributions to synthetic chemistry, including developing new copper-catalyzed alkene additions that enable concise de novo synthesis of enantioenriched saturated nitrogen and oxygen heterocycles.”

Sherry Chemler , PhD, is a professor in the Department of Chemistry in the College of Arts and Sciences who has developed groundbreaking chemical methods that can aid drug discovery. In the mid-2000s, she invented new copper-catalyzed alkene additions that enabled concise synthesis of chiral nitrogen and oxygen heterocycles — valuable organic compounds that enable drug discovery. Supported by the National Institutes of Health and the American Chemical Society, Chemler and her team have spent the ensuing years expanding the scope of the transformations. A collaborator with Roswell Park Comprehensive Cancer Center, she has several ongoing projects to address challenges in drug discovery related to potency, selectivity and metabolism. Her publications have been cited over 8,200 times and she has been an associate editor for the AAAS journal Science Advances since 2016. 

Jean-Pierre Koenig

“For distinguished contributions to the language sciences and for integrating formal syntax and semantics studies of lexical knowledge across languages of the world with experimental, corpus, and computational techniques.”

Jean-Pierre Koenig , PhD, professor in the Department of Linguistics in the College of Arts and Sciences, studies the organization and use of words in a diverse array of languages, from English to Oneida. His work has focused on verbs, how their structure and meaning vary across languages, as well as how we deploy our vocabulary — especially of words with more than one meaning — when we read. One of his current projects is a comprehensive study of the structure of Oneida, an Iroquoian language, which will challenge the idea that certain properties of language are universal. His work has been published extensively and includes contributions to many language sciences disciplines, including to the “Grande Grammaire du français,” the largest comprehensive grammar of French written in the last 100 years.

Kemper Lewis

“For distinguished contributions to the field of design automation, advancing both fundamental decision theory and novel applications to systems design, design analytics, and Industry 4.0.”

Kemper E. Lewis , PhD, dean of the School of Engineering and Applied Sciences and professor in the Department of Mechanical and Aerospace Engineering, is a global leader in engineering design, system optimization and advanced manufacturing. He is director of UB’s Community of Excellence in Sustainable Manufacturing and Advanced Robotic Technologies (SMART), which develops advanced manufacturing and design automation solutions. Lewis is a Fellow of the American Society of Mechanical Engineers (ASME), and has served on the National Academies Panel on Benchmarking the Research Competitiveness of the United States in Mechanical Engineering. He has published over 200 refereed journal articles and conference proceedings and has been principal or co-principal investigator on grants totaling more than $33 million.

Gabriela Popescu

“For distinguished contributions to the field of molecular neuroscience, particularly in elucidating structural and functional aspects of neurotransmission in the central nervous system in health and disease.”

Gabriella K. Popescu , PhD, is a professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences. Her research centers around NMDA receptors, which produce electrical currents that are essential for cognition, learning and memory. Her current eight-year research grant from the National Institutes of Health focuses on the excess activation of these receptors, which can cause pathological cellular loss in stroke, brain and spinal cord diseases, including Alzheimer’s and Parkinson’s disease. Popescu uses her leadership positions in national organizations to promote diversity and inclusion in academic medicine as well as public support for the sciences.

Thomas Russo

“For distinguished contributions to the field of bacterial pathogenesis, and the development of therapeutics, as well as distinguished contributions as an educator of the public, schools, and businesses throughout the COVID-19 pandemic.”

Thomas A. Russo , MD, SUNY Distinguished Professor in the Department of Medicine in the Jacobs School, is an expert in infectious diseases. Russo, who cares for patients at the VA of Western New York, conducts research on gram-negative bacterial infections, antibiotic-resistant infections and works on developing targeted vaccines and drugs. Russo led the team that discovered the first biomarkers that help identify hypervirulent Klebsiella pneumonaie, a potentially lethal pathogen that can infect healthy individuals. He is also a go-to source for national and global media, sought for his straightforward explanations of complex medical topics.

Frederick W. Stoss

“For distinguished contributions in science librarianship and related realms, especially to provide scholars, students, and the general public with sound information relating to environmental issues.”

Frederick W. Stoss , MLS, and his service to the university, the library profession and the community has been guided by a deep commitment to education, equity, access, social justice, environmental responsibility and stewardship. His 40-year career in library and information sciences includes prior experience as a research scientist in the areas of toxicology and environmental health. This rich background provided Stoss with extensive and invaluable insights that contributed to the academic success and professional and personal group of UB faculty, students and staff in the areas of research, teaching and learning.

“For distinguished contributions to the field of science communication by evaluating public risk perceptions of various diseases and environmental hazards and conveying this information to the public and researchers.”

Janet Yang , PhD, professor in the Department of Communication in the College of Arts and Sciences, studies how people perceive risks related to science, health and environmental topics. Funded by multiple grants from the National Science Foundation, Yang’s work has revealed that many Americans did not want to get the COVID-19 and mpox vaccines because they viewed the vaccines as not sufficiently researched and therefore carry too much uncertainty, a finding that provides critical insight for vaccination messaging. She and her team have also examined risk perception in relation to climate change and per- and poly-fluoroalkyl substances (PFAS) pollution. Currently, as part of UB's Initiative for Plastics Recycling Research and Innovation, Yang explores effective communication strategies to encourage New York State residents to recycle, reduce, and reuse more effectively. 

Media Contact Information

Media Relations (University Communications) 330 Crofts Hall (North Campus) Buffalo, NY 14260-7015 Tel: 716-645-6969 [email protected]

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