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Understanding the Parts of a Research Paper

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Research Writing ~ How to Write a Research Paper

• Choosing A Topic
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• Starting Your Research
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• Parts of the Paper
• Edit & Rewrite
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Papers should have a beginning, a middle, and an end. Your introductory paragraph should grab the reader's attention, state your main idea and how you will support it. The body of the paper should expand on what you have stated in the introduction. Finally, the conclusion restates the paper's thesis and should explain what you have learned, giving a wrap up of your main ideas.   

1. The Title The title should be specific and indicate the theme of the research and what ideas it addresses. Use keywords that help explain your paper's topic to the reader. Try to avoid  abbreviations  and  jargon.  Think about keywords that people would use to search for your paper and include them in your title. 

2. The Abstract The abstract is used by readers to get a quick overview of your paper. Typically, they are about 200 words in length (120 words minimum to  250 words maximum). The abstract should introduce the topic and thesis, and should provide a general statement about what you have found in your research. The abstract allows you to mention each major aspect of you topic and helps readers decide whether they want to read the rest of the paper. Because it is a summary of the entire research paper, it is often written last. 

3. The Introduction The introduction should be designed to attract the reader's attention and explain the focus of the research. You will introduce your overview of the topic, your main points of information, and why this subject is important. You can introduce the current understanding and background information about the topic. Toward the end of the introduction, you add your thesis statement, and explain how you will provide information to support your research questions. This provides the purpose, focus, and structure for the rest of the paper.

4. Thesis Statement Most papers will have a thesis statement or main idea and supporting facts/ideas/arguments. State your main idea (something of interest or something to be proven or argued for or against) as your thesis statement, and then provide  supporting facts and arguments. A thesis statement is a declarative sentence that asserts the position a paper will be taking. It also points toward the paper's development. This statement should be both specific and arguable. Generally, the thesis statement will be placed at the end of the first paragraph of your paper. The remainder of your paper will support this thesis.

Students often learn to write a thesis as a first step in the writing process, but often, after research, a writers viewpoint may change. Therefore a thesis statement may be one of the final steps in writing. 

Examples of thesis statements from Purdue OWL. . .

5. The Literature Review The purpose of the literature review is to describe past important research and how it specifically relates to the research thesis. It should be a synthesis of the previous literature and the new idea being researched. The review should examine the major theories related to the topic to date and their contributors. It should include all relevant findings from credible sources, such as academic books and peer-reviewed journal articles. You will want  to:

• Explain how the literature helps the researcher understand the topic.
• Try to show connections and any disparities between the literature.
• Identify new ways to interpret prior research.
• Reveal any gaps that exist in the literature.

More about writing a literature review. . .  from The Writing Center at UNC-Chapel Hill More about summarizing. . . from the Center for Writing Studies at the University of Illinois-Urbana Champaign

6. The Discussion ​The purpose of the discussion is to interpret and describe what you have learned from your research. Make the reader understand why your topic is important. The discussion should always demonstrate what you have learned from your readings (and viewings) and how that learning has made the topic evolve, especially from the short description of main points in the introduction. Explain any new understanding or insights you have had after reading your articles and/or books. Paragraphs should use transitioning sentences to develop how one paragraph idea leads to the next. The discussion will always connect to the introduction, your thesis statement, and the literature you reviewed, but it does not simply repeat or rearrange the introduction. You want to: 

• Demonstrate critical thinking, not just reporting back facts that you gathered.
• If possible, tell how the topic has evolved over the past and give it's implications for the future.
• Fully explain your main ideas with supporting information.
• Explain why your thesis is correct giving arguments to counter points.

​7. The Conclusion A concluding paragraph is a brief summary of your main ideas and restates the paper's main thesis, giving the reader the sense that the stated goal of the paper has been accomplished. What have you learned by doing this research that you didn't know before? What conclusions have you drawn? You may also want to suggest further areas of study, improvement of research possibilities, etc. to demonstrate your critical thinking regarding your research.

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How to present a research paper in PPT: best practices

A research paper presentation is frequently used at conferences and other events where you have a chance to share the results of your research and receive feedback from colleagues. Although it may appear as simple as summarizing the findings, successful examples of research paper presentations show that there is a little bit more to it.

In this article, we’ll walk you through the basic outline and steps to create a good research paper presentation. We’ll also explain what to include and what not to include in your presentation of research paper and share some of the most effective tips you can use to take your slides to the next level.

Research paper PowerPoint presentation outline

Creating a PowerPoint presentation for a research paper involves organizing and summarizing your key findings, methodology, and conclusions in a way that encourages your audience to interact with your work and share their interest in it with others. Here’s a basic research paper outline PowerPoint you can follow:

1. Title (1 slide)

Typically, your title slide should contain the following information:

• Title of the research paper
• Affiliation or institution
• Date of presentation

2. Introduction (1-3 slides)

On this slide of your presentation, briefly introduce the research topic and its significance and state the research question or objective.

3. Research questions or hypothesis (1 slide)

This slide should emphasize the objectives of your research or present the hypothesis.

4. Literature review (1 slide)

Your literature review has to provide context for your research by summarizing relevant literature. Additionally, it should highlight gaps or areas where your research contributes.

5. Methodology and data collection (1-2 slides)

This slide of your research paper PowerPoint has to explain the research design, methods, and procedures. It must also Include details about participants, materials, and data collection and emphasize special equipment you have used in your work.

6. Results (3-5 slides)

On this slide, you must present the results of your data analysis and discuss any trends, patterns, or significant findings. Moreover, you should use charts, graphs, and tables to illustrate data and highlight something novel in your results (if applicable).

7. Conclusion (1 slide)

Your conclusion slide has to summarize the main findings and their implications, as well as discuss the broader impact of your research. Usually, a single statement is enough.

8. Recommendations (1 slide)

If applicable, provide recommendations for future research or actions on this slide.

9. References (1-2 slides)

The references slide is where you list all the sources cited in your research paper.

10. Acknowledgments (1 slide)

On this presentation slide, acknowledge any individuals, organizations, or funding sources that contributed to your research.

11. Appendix (1 slide)

If applicable, include any supplementary materials, such as additional data or detailed charts, in your appendix slide.

The above outline is just a general guideline, so make sure to adjust it based on your specific research paper and the time allotted for the presentation.

Steps to creating a memorable research paper presentation

Creating a PowerPoint presentation for a research paper involves several critical steps needed to convey your findings and engage your audience effectively, and these steps are as follows:

Step 1. Understand your audience:

• Identify the audience for your presentation.
• Tailor your content and level of detail to match the audience’s background and knowledge.

Step 2. Define your key messages:

• Clearly articulate the main messages or findings of your research.
• Identify the key points you want your audience to remember.

Step 3. Design your research paper PPT presentation:

• Use a clean and professional design that complements your research topic.
• Choose readable fonts, consistent formatting, and a limited color palette.
• Opt for PowerPoint presentation services if slide design is not your strong side.

Step 4. Put content on slides:

• Follow the outline above to structure your presentation effectively; include key sections and topics.
• Organize your content logically, following the flow of your research paper.

Step 5. Final check:

• Proofread your slides for typos, errors, and inconsistencies.
• Ensure all visuals are clear, high-quality, and properly labeled.

Step 6. Save and share:

• Save your presentation and ensure compatibility with the equipment you’ll be using.
• If necessary, share a copy of your presentation with the audience.

By following these steps, you can create a well-organized and visually appealing research paper presentation PowerPoint that effectively conveys your research findings to the audience.

What to include and what not to include in your presentation

In addition to the must-know PowerPoint presentation recommendations, which we’ll cover later in this article, consider the following do’s and don’ts when you’re putting together your research paper presentation:

• Focus on the topic.
• Be brief and to the point.
• Attract the audience’s attention and highlight interesting details.
• Use only relevant visuals (maps, charts, pictures, graphs, etc.).
• Use numbers and bullet points to structure the content.
• Make clear statements regarding the essence and results of your research.

Don’ts:

• Don’t write down the whole outline of your paper and nothing else.
• Don’t put long, full sentences on your slides; split them into smaller ones.
• Don’t use distracting patterns, colors, pictures, and other visuals on your slides; the simpler, the better.
• Don’t use too complicated graphs or charts; only the ones that are easy to understand.
• Now that we’ve discussed the basics, let’s move on to the top tips for making a powerful presentation of your research paper.

8 tips on how to make research paper presentation that achieves its goals

You’ve probably been to a presentation where the presenter reads word for word from their PowerPoint outline. Or where the presentation is cluttered, chaotic, or contains too much data. The simple tips below will help you summarize a 10 to 15-page paper for a 15 to 20-minute talk and succeed, so read on!

Tip #1: Less is more

You want to provide enough information to make your audience want to know more. Including details but not too many and avoiding technical jargon, formulas, and long sentences are always good ways to achieve this.

Tip #2: Be professional

Avoid using too many colors, font changes, distracting backgrounds, animations, etc. Bullet points with a few words to highlight the important information are preferable to lengthy paragraphs. Additionally, include slide numbers on all PowerPoint slides except for the title slide, and make sure it is followed by a table of contents, offering a brief overview of the entire research paper.

Tip #3: Strive for balance

PowerPoint slides have limited space, so use it carefully. Typically, one to two points per slide or 5 lines for 5 words in a sentence are enough to present your ideas.

Tip #4: Use proper fonts and text size

The font you use should be easy to read and consistent throughout the slides. You can go with Arial, Times New Roman, Calibri, or a combination of these three. An ideal text size is 32 points, while a heading size is 44.

Tip #5: Concentrate on the visual side

A PowerPoint presentation is one of the best tools for presenting information visually. Use graphs instead of tables and topic-relevant illustrations instead of walls of text. Keep your visuals as clean and professional as the content of your presentation.

Tip #6: Practice your delivery

Always go through your presentation when you’re done to ensure a smooth and confident delivery and time yourself to stay within the allotted limit.

Tip #7: Get ready for questions

Anticipate potential questions from your audience and prepare thoughtful responses. Also, be ready to engage in discussions about your research.

Tip #8: Don’t be afraid to utilize professional help

If the mere thought of designing a presentation overwhelms you or you’re pressed for time, consider leveraging professional PowerPoint redesign services . A dedicated design team can transform your content or old presentation into effective slides, ensuring your message is communicated clearly and captivates your audience. This way, you can focus on refining your delivery and preparing for the presentation.

Lastly, remember that even experienced presenters get nervous before delivering research paper PowerPoint presentations in front of the audience. You cannot know everything; some things can be beyond your control, which is completely fine. You are at the event not only to share what you know but also to learn from others. So, no matter what, dress appropriately, look straight into the audience’s eyes, try to speak and move naturally, present your information enthusiastically, and have fun!

If you need help with slide design, get in touch with our dedicated design team and let qualified professionals turn your research findings into a visually appealing, polished presentation that leaves a lasting impression on your audience. Our experienced designers specialize in creating engaging layouts, incorporating compelling graphics, and ensuring a cohesive visual narrative that complements content on any subject.

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Major Parts of a Research Paper - PowerPoint PPT Presentation

Major Parts of a Research Paper

Watch this presentation to write each part of a research paper correctly – powerpoint ppt presentation.

• Introduction
• Reference List
• The first part of the research paper is one of the most important because the outline is given there.
• Three major parts are included in great introductions background to the issue or goal of the research the outline of the paper, basically you describe the order which you will use for achieving the goal of work description of your own position on the subject or issue. The length of the parts varies from paper to paper and usually established by the writer.
• This is supposed to be the easiest part because the method of the research is already established.
• Explain your methods in detail so the reader will be aware of the scientific aspect of the research.
• In case when you are writing a survey, be sure to include questionnaire in the appendix of your paper.
• The results considered to be very variable and depend on the outcome of the research by the student.
• If the paper deals with numerical data, it should be represented in this section.
• The student needs to give the results in detail in this case.
• On the other hand, qualitative research should have more thorough discussion of the issue in the results.
• Explanation of the results of the research as well as personal thoughts is represented in this part.
• The key here is to address every point separately and give clear information about the problem.
• Also the writer should remember that the points must be directly connected to the main idea of the paper in order to be successful.
• Final part refers to the findings of the paper and builds up conclusions about the thesis statement.
• The size of the part depends on the length of the main part but usually consists of several paragraphs.
• Some people think that the conclusion is the main part of research paper because it reveals the importance of the research as well as recommends new ways of resolving the problem or issue.
• This is where the sources of the information are documented.
• Without them the paper is not complete because you have to identify where the information was taken from.
• If you need any help with completing your research paper, you can always take ours
• https//essay-academy.com

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NIST CSWP 36 (Initial Public Draft)

Applying 5g cybersecurity and privacy capabilities: introduction to the white paper series.

    Documentation     Topics

Date Published: August 15, 2024 Comments Due: September 16, 2024 Email Comments to: [email protected]

Michael Bartock (NIST) , Jeffrey Cichonski (NIST) , Murugiah Souppaya (NIST) , Karen Scarfone (NIST) , Parisa Grayeli (MITRE) , Sanjeev Sharma (MITRE) , Thomas McCarthy (AMI) , Muthukkumaran Ramalingam (AMI) , Presanna Raman (AMI) , Stefano Righi (AMI) , Jitendra Patel (AT&T) , Bogdan Ungureanu (AT&T) , Tao Wan (CableLabs) , Matthew Hyatt (Cisco) , Steve Vetter (Cisco) , Dan Carroll (Dell Technologies) , Steve Orrin (Intel) , Corey Piggott (Keysight Technologies) , Michael Yeh (MiTAC Computing) , Gary Atkinson (Nokia Bell Labs) , Rajasekhar Bodanki (Nokia Bell Labs) , Don McBride (Nokia Bell Labs) , Aarin Buskirk (Palo Alto Networks) , Bryan Wenger (Palo Alto Networks) , Todd Gibson (T-Mobile)

Announcement

5G technology for broadband cellular networks will significantly improve how humans and machines communicate, operate, and interact in the physical and virtual world. 5G provides increased bandwidth and capacity, and low latency. However, professionals in fields like technology, cybersecurity, and privacy are faced with safeguarding this technology while its development, deployment, and usage are still evolving.

To help, the NIST National Cybersecurity Center of Excellence (NCCoE) has launched the Applying 5G Cybersecurity and Privacy Capabilities white paper series. The series targets technology, cybersecurity, and privacy program managers within commercial mobile network operators, potential private 5G network operators, and organizations using and managing 5G-enabled technology who are concerned with how to identify, understand, assess, and mitigate risk for 5G networks. In the series we provide recommended practices and illustrate how to implement them. All of the capabilities featured in the white papers have been implemented in the NCCoE testbed on commercial-grade 5G equipment.

We are pleased to announce the following white paper which introduces the series: Applying 5G Cybersecurity and Privacy Capabilities: Introduction to the White Paper Series . This publication explains what you can expect from each part of the series: information, guidance, recommended practices, and research findings for a specific technical cybersecurity or privacy-supporting capability available in 5G systems or their supporting infrastructures.

This document introduces the white paper series titled Applying 5G Cybersecurity and Privacy Capabilities. This series is being published by the National Cybersecurity Center of Excellence (NCCoE) 5G Cybersecurity project. Each paper in the series will include information, guidance, and research findings for an individual technical cybersecurity- or privacy-supporting capability available in 5G systems or their supporting infrastructures. Each of the capabilities has been implemented in a testbed as part of the NCCoE project, and each white paper reflects the results of that implementation and its testing.

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Documentation

Publication: https://doi.org/10.6028/NIST.CSWP.36.ipd Download URL

Supplemental Material: 5G Cybersecurity Project

Publication Parts: CSWP 36A

Document History: 08/15/24: CSWP 36 (Draft)

general security & privacy

communications & wireless

telecommunications

Chapter 5 Summary, Conclusions, Discussions, &amp; Recommendations

Jul 29, 2014

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Chapter 5 Summary, Conclusions, Discussions, &amp; Recommendations . Applied Research Center Abraham S. Fischler School of Education Summer Conference 2012. General Information. This session will address the components of Chapter 5 of the Applied Dissertation.

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Presentation Transcript

Chapter 5 Summary, Conclusions, Discussions, & Recommendations Applied Research Center Abraham S. Fischler School of Education Summer Conference 2012

General Information This session will address the components of Chapter 5 of the Applied Dissertation. The format and style of Chapter 5 should follow the Style Guide for the Applied Dissertationand the sixth edition of the APA manual.

Chapter 5 Purpose of Chapter 5: To provide the readers with a thorough understanding of what the results of your study mean to the research field and to professional practice.

Chapter 5 Chapter 5 allows you to summarize the findings, discuss the importance of the findings, place the research findings in the context of current literature, compare and contrast the research findings with other relevant research, identify the strengths and weaknesses of the research study, discuss the implications of the research findings, and make recommendations for future research.

Summary of Findings Restate the results presented in Chapter 4 using little or no statistical jargon. Write in a clear straightforward manner with no interpretation of the results. Use past tense. Do not include tables and figures. Identify whether the findings of your study supported the hypotheses or research questions. Present unusual findings (e.g., results that you did not expect to be significant but were, and vice versa).

Interpretation of Findings Analyze both significant findings and not significant findings. Were the results what you predicted? Why do you think the results turned out the way they did? Were there any issues related to sampling, measurement, and procedural issues, as well as confounding variables? Provide possible explanations for the results. Link the results to any theoretical framework you used to develop your research question or hypotheses.

Context of Findings Place your findings in perspective to other studies of the topic found in the reviewed literature. How are your findings similar or different from those of other studies? Based on the literature, are the findings what might have been expected? If your results differ from those of other studies, what plausible explanations can account for this?

Implications of Findings • How do the findings expand the understanding of the phenomenon under study? • Identify the implications of the findings for • Theory: Are findings consistent with current theories in the field? Are they consistent with the selected theoretical framework for your study? • Research: Does the study help advance the research methodology in the field? (e.g., understanding of new confounding variables, issues of measurement, issues of design) • Practice: Who may be interested in using these findings in a professional field? Why should they pay attention to the findings? Could the findings lead to changes in the way professionals “do” things?

Discussion on Limitations Review the potential limitations that you initially proposed in the proposal. Discuss the limitations that may have affected—one way or another—your findings. Limitations typically originate in one of two sources: the study’s design and the study’s problems during implementation. Issues of design involve decisions about sampling, assessment, procedures, and choice of research design (poor match). Some of the issues that may have arisen at the time of research implementation relate to low sample size, measurement issues, heterogeneous groups, and so forth.

Discussion on Limitations (Cont.) Think of limitations in four major areas: Internal Validity—Unless the study is a “true experiment” one cannot claim that the IV “caused” changes in the DV. External Validity—Discuss the extent to which findings can be generalized. Measurement—Discuss issues of reliability and validity of assessment instruments. Statistical Analysis—Discuss issues of power, effect size, conservative or liberal statistics, and statistical test chosen.

Discussion on Future Directions Discuss findings in light of questions or issues that suggest future research directions. Extend the study to other populations. Think of other IVs and DVs that ought to be explored in the field; also, think of how to assess those additional variables. This is the section of the paper where most researchers are allowed to dream; think of extending your study to other questions that may add to the understanding of the issues.

Bibliography Cone, J. D., & Foster, S. F. (2006). Dissertations and theses from start to finish: Psychology and related fields. Washington, DC: American Psychological Association. Cottrell, R. R., & McKenzie, J. F. (2011). Health Promotion and education research methods: Using the five-chapter thesis/dissertation model (2nd ed.). Sudbury, MA: Jones and Bartlett.

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Sodhi M , Rezaeianzadeh R , Kezouh A , Etminan M. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss. JAMA. 2023;330(18):1795–1797. doi:10.1001/jama.2023.19574

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Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss

• 1 Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
• 2 StatExpert Ltd, Laval, Quebec, Canada
• 3 Department of Ophthalmology and Visual Sciences and Medicine, University of British Columbia, Vancouver, Canada
• Medical News & Perspectives As Ozempic’s Popularity Soars, Here’s What to Know About Semaglutide and Weight Loss Melissa Suran, PhD, MSJ JAMA
• Special Communication Patents and Regulatory Exclusivities on GLP-1 Receptor Agonists Rasha Alhiary, PharmD; Aaron S. Kesselheim, MD, JD, MPH; Sarah Gabriele, LLM, MBE; Reed F. Beall, PhD; S. Sean Tu, JD, PhD; William B. Feldman, MD, DPhil, MPH JAMA
• Medical News & Perspectives What to Know About Wegovy’s Rare but Serious Adverse Effects Kate Ruder, MSJ JAMA
• Comment & Response GLP-1 Receptor Agonists and Gastrointestinal Adverse Events—Reply Ramin Rezaeianzadeh, BSc; Mohit Sodhi, MSc; Mahyar Etminan, PharmD, MSc JAMA
• Comment & Response GLP-1 Receptor Agonists and Gastrointestinal Adverse Events Karine Suissa, PhD; Sara J. Cromer, MD; Elisabetta Patorno, MD, DrPH JAMA
• Research Letter GLP-1 Receptor Agonist Use and Risk of Postoperative Complications Anjali A. Dixit, MD, MPH; Brian T. Bateman, MD, MS; Mary T. Hawn, MD, MPH; Michelle C. Odden, PhD; Eric C. Sun, MD, PhD JAMA
• Original Investigation Glucagon-Like Peptide-1 Receptor Agonist Use and Risk of Gallbladder and Biliary Diseases Liyun He, MM; Jialu Wang, MM; Fan Ping, MD; Na Yang, MM; Jingyue Huang, MM; Yuxiu Li, MD; Lingling Xu, MD; Wei Li, MD; Huabing Zhang, MD JAMA Internal Medicine
• Research Letter Cholecystitis Associated With the Use of Glucagon-Like Peptide-1 Receptor Agonists Daniel Woronow, MD; Christine Chamberlain, PharmD; Ali Niak, MD; Mark Avigan, MDCM; Monika Houstoun, PharmD, MPH; Cindy Kortepeter, PharmD JAMA Internal Medicine

Glucagon-like peptide 1 (GLP-1) agonists are medications approved for treatment of diabetes that recently have also been used off label for weight loss. 1 Studies have found increased risks of gastrointestinal adverse events (biliary disease, 2 pancreatitis, 3 bowel obstruction, 4 and gastroparesis 5 ) in patients with diabetes. 2 - 5 Because such patients have higher baseline risk for gastrointestinal adverse events, risk in patients taking these drugs for other indications may differ. Randomized trials examining efficacy of GLP-1 agonists for weight loss were not designed to capture these events 2 due to small sample sizes and short follow-up. We examined gastrointestinal adverse events associated with GLP-1 agonists used for weight loss in a clinical setting.

We used a random sample of 16 million patients (2006-2020) from the PharMetrics Plus for Academics database (IQVIA), a large health claims database that captures 93% of all outpatient prescriptions and physician diagnoses in the US through the International Classification of Diseases, Ninth Revision (ICD-9) or ICD-10. In our cohort study, we included new users of semaglutide or liraglutide, 2 main GLP-1 agonists, and the active comparator bupropion-naltrexone, a weight loss agent unrelated to GLP-1 agonists. Because semaglutide was marketed for weight loss after the study period (2021), we ensured all GLP-1 agonist and bupropion-naltrexone users had an obesity code in the 90 days prior or up to 30 days after cohort entry, excluding those with a diabetes or antidiabetic drug code.

Patients were observed from first prescription of a study drug to first mutually exclusive incidence (defined as first ICD-9 or ICD-10 code) of biliary disease (including cholecystitis, cholelithiasis, and choledocholithiasis), pancreatitis (including gallstone pancreatitis), bowel obstruction, or gastroparesis (defined as use of a code or a promotility agent). They were followed up to the end of the study period (June 2020) or censored during a switch. Hazard ratios (HRs) from a Cox model were adjusted for age, sex, alcohol use, smoking, hyperlipidemia, abdominal surgery in the previous 30 days, and geographic location, which were identified as common cause variables or risk factors. 6 Two sensitivity analyses were undertaken, one excluding hyperlipidemia (because more semaglutide users had hyperlipidemia) and another including patients without diabetes regardless of having an obesity code. Due to absence of data on body mass index (BMI), the E-value was used to examine how strong unmeasured confounding would need to be to negate observed results, with E-value HRs of at least 2 indicating BMI is unlikely to change study results. Statistical significance was defined as 2-sided 95% CI that did not cross 1. Analyses were performed using SAS version 9.4. Ethics approval was obtained by the University of British Columbia’s clinical research ethics board with a waiver of informed consent.

Our cohort included 4144 liraglutide, 613 semaglutide, and 654 bupropion-naltrexone users. Incidence rates for the 4 outcomes were elevated among GLP-1 agonists compared with bupropion-naltrexone users ( Table 1 ). For example, incidence of biliary disease (per 1000 person-years) was 11.7 for semaglutide, 18.6 for liraglutide, and 12.6 for bupropion-naltrexone and 4.6, 7.9, and 1.0, respectively, for pancreatitis.

Use of GLP-1 agonists compared with bupropion-naltrexone was associated with increased risk of pancreatitis (adjusted HR, 9.09 [95% CI, 1.25-66.00]), bowel obstruction (HR, 4.22 [95% CI, 1.02-17.40]), and gastroparesis (HR, 3.67 [95% CI, 1.15-11.90) but not biliary disease (HR, 1.50 [95% CI, 0.89-2.53]). Exclusion of hyperlipidemia from the analysis did not change the results ( Table 2 ). Inclusion of GLP-1 agonists regardless of history of obesity reduced HRs and narrowed CIs but did not change the significance of the results ( Table 2 ). E-value HRs did not suggest potential confounding by BMI.

This study found that use of GLP-1 agonists for weight loss compared with use of bupropion-naltrexone was associated with increased risk of pancreatitis, gastroparesis, and bowel obstruction but not biliary disease.

Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes. Limitations include that although all GLP-1 agonist users had a record for obesity without diabetes, whether GLP-1 agonists were all used for weight loss is uncertain.

Accepted for Publication: September 11, 2023.

Published Online: October 5, 2023. doi:10.1001/jama.2023.19574

Correction: This article was corrected on December 21, 2023, to update the full name of the database used.

Corresponding Author: Mahyar Etminan, PharmD, MSc, Faculty of Medicine, Departments of Ophthalmology and Visual Sciences and Medicine, The Eye Care Center, University of British Columbia, 2550 Willow St, Room 323, Vancouver, BC V5Z 3N9, Canada ( [email protected] ).

Author Contributions: Dr Etminan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Sodhi, Rezaeianzadeh, Etminan.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Sodhi, Rezaeianzadeh, Etminan.

Critical review of the manuscript for important intellectual content: All authors.

Statistical analysis: Kezouh.

Obtained funding: Etminan.

Administrative, technical, or material support: Sodhi.

Supervision: Etminan.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was funded by internal research funds from the Department of Ophthalmology and Visual Sciences, University of British Columbia.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Data Sharing Statement: See Supplement .

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